Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99MagnesiumUniRule annotation1
Binding sitei102XanthineUniRule annotation1
Binding sitei145Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00602;UER00658

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotation
Ordered Locus Names:RHE_CH01754
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000001936 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002610121 – 164Xanthine phosphoribosyltransferaseAdd BLAST164

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi347834.RHE_CH01754

Structurei

3D structure databases

ProteinModelPortaliQ2K9D7
SMRiQ2K9D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 425-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni102 – 1065-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DYA Bacteria
COG0503 LUCA
KOiK00769
OMAiFHRDCRA

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01903 XGPRT, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023747 Xanthine_Guanine_PRibTrfase
PANTHERiPTHR39563 PTHR39563, 1 hit
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

Q2K9D7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPDKAFPV SWDQFHRDAR ALAWRLAGLD QTFKAIVCIT RGGLVPAAII
60 70 80 90 100
SRELNIRLIE TVCIASYHDY VNQGDMVLLK GIAPELAENG GEGVLVVDDL
110 120 130 140 150
TDTGKTAAQV RTMLPKAHFA CVYAKPKGVP TVDTFITEVS QDTWIYFPWD
160
MGFTYQEPIA KGAR
Length:164
Mass (Da):18,116
Last modified:March 7, 2006 - v1
Checksum:i6633F9EEE570A173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000133 Genomic DNA Translation: ABC90549.1
RefSeqiWP_010025058.1, NC_007761.1

Genome annotation databases

EnsemblBacteriaiABC90549; ABC90549; RHE_CH01754
GeneIDi24300151
KEGGiret:RHE_CH01754

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000133 Genomic DNA Translation: ABC90549.1
RefSeqiWP_010025058.1, NC_007761.1

3D structure databases

ProteinModelPortaliQ2K9D7
SMRiQ2K9D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi347834.RHE_CH01754

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC90549; ABC90549; RHE_CH01754
GeneIDi24300151
KEGGiret:RHE_CH01754

Phylogenomic databases

eggNOGiENOG4105DYA Bacteria
COG0503 LUCA
KOiK00769
OMAiFHRDCRA

Enzyme and pathway databases

UniPathwayi
UPA00602;UER00658

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01903 XGPRT, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023747 Xanthine_Guanine_PRibTrfase
PANTHERiPTHR39563 PTHR39563, 1 hit
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXGPT_RHIEC
AccessioniPrimary (citable) accession number: Q2K9D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 7, 2006
Last modified: October 10, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again