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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp), ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei363Proton donorUniRule annotation1
Active sitei394UniRule annotation1
Active sitei522UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Francci3_0045
OrganismiFrankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001937 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002526221 – 556Glucose-6-phosphate isomeraseAdd BLAST556

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_0045

Structurei

3D structure databases

ProteinModelPortaliQ2JH03
SMRiQ2JH03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2JH03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTEPAAPV APLDITATEE WAALTTHLRE ISEVSLRDLF AADPRRGETF
60 70 80 90 100
AAEADGLYLD YSKNRLTART VELLTALARR AGLADRIEAM FRGERINVTE
110 120 130 140 150
NRPVLHVALR APAGTRIEVD GVDVVPDVHR VLDAMSQFAD RVRSGDWLGA
160 170 180 190 200
TGERIRTVVN IGIGGSDLGP AMAYDALRDY ADRSIEVRFV SNVDPTDIWE
210 220 230 240 250
ATADLDPAST LFIVSSKTFT TLETISNARA ARSWLTGLLG EDAVSRHFVA
260 270 280 290 300
VSTNAEKVAE FGIDTVNMFE FWDWVGGRYS VDCAIGLSLM IAIGPPNFRE
310 320 330 340 350
FLAGFAAMDT HFRTAPFERN LPVLLGLIGL WYRDFFGTAT HAVLPYSHYL
360 370 380 390 400
GRFPAYLQQL DMESNGKSVD LTGRPVSTPT GPIVWGTPGT NGQHAYYQLL
410 420 430 440 450
HQGTTIVPAD FIGFVRPNHP GVGTADGAGV DQHALLLANF LAQTEALAFG
460 470 480 490 500
RTAAEVAAEG VTPDLVAHRT FPGNRPSNTL LAQKLTPFAL GQLIALYEHK
510 520 530 540 550
VFTQGVIWGI NSFDQWGVEL GKVLAGRIIP ELGSEQEPEL GHDSSTNALI

KRLRAG
Length:556
Mass (Da):60,424
Last modified:March 7, 2006 - v1
Checksum:i38F6F4CD01D177A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA Translation: ABD09439.1
RefSeqiWP_011434521.1, NZ_JENI01000001.1

Genome annotation databases

EnsemblBacteriaiABD09439; ABD09439; Francci3_0045
GeneIDi32155082
KEGGifra:Francci3_0045

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA Translation: ABD09439.1
RefSeqiWP_011434521.1, NZ_JENI01000001.1

3D structure databases

ProteinModelPortaliQ2JH03
SMRiQ2JH03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi106370.Francci3_0045

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD09439; ABD09439; Francci3_0045
GeneIDi32155082
KEGGifra:Francci3_0045

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00181

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_FRACC
AccessioniPrimary (citable) accession number: Q2JH03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 7, 2006
Last modified: October 10, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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