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Protein

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B

Gene

inppl1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Hydrolase
Biological processCell adhesion, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B (EC:3.1.3.86)
Alternative name(s):
Inositol polyphosphate phosphatase-like protein 1B
Short name:
INPPL-1B
SH2 domain-containing inositol 5'-phosphatase 2B
Short name:
SH2 domain-containing inositol phosphatase 2B
Short name:
SHIP-2B
Gene namesi
Name:inppl1b
Synonyms:inppl1, ship2b
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030616-75 inppl1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028741 – 1226Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2BAdd BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei909PhosphotyrosineBy similarity1

Post-translational modificationi

Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2I6J0
PRIDEiQ2I6J0

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096523

Structurei

3D structure databases

ProteinModelPortaliQ2I6J0
SMRiQ2I6J0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 102SH2PROSITE-ProRule annotationAdd BLAST97
Domaini1163 – 1226SAMPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi906 – 909NPXY motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1008 – 1092Pro-richAdd BLAST85

Domaini

The SH2 domain interacts with tyrosine phosphorylated forms of proteins.By similarity
The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.By similarity

Sequence similaritiesi

Keywords - Domaini

SH2 domain, SH3-binding

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
HOGENOMiHOG000004836
HOVERGENiHBG106726
InParanoidiQ2I6J0
PhylomeDBiQ2I6J0

Family and domain databases

Gene3Di3.30.505.10, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR000300 IPPc
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF55550 SSF55550, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS50001 SH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q2I6J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGAPWYHRD ISRVRAEELL AHAGIDGSFL VRDSESVPGA YALCLLFQRH
60 70 80 90 100
VHTYRILPDA DGLLAVQATQ GVQVNCFRTL GDLVLGYQNP NKGLVAPLLY
110 120 130 140 150
PVMRESEAND ESSDGDDEKP GSTFANSPPR AISPTATSPP SSSAAPHLLL
160 170 180 190 200
QRLQELSPNS VGCEIVSLLD EYLHGNVCKD LENLKGGASG LQHFQGILSH
210 220 230 240 250
ICDSLHSEID QTLSSLETLA KVFDHPSGHL TFSTMQNIGK SPEENMDNLL
260 270 280 290 300
QKLTTLCNLL SSLEKRVLKA LQEAVANHNL SLQPATPPES SRAPKKLARP
310 320 330 340 350
NPVHSFQVKV VRYGRQTVSV DINEGVLLFD KKSGSFGVET VTLDRIVQLV
360 370 380 390 400
KFQRGPAKLK MVVDSHHNPP RELVFESTKK REAFCRLLQL MKTTHSQKSE
410 420 430 440 450
LDVISVFVGT WNMGGTPPPG SLQSWVTCSG LGLTPDESIS SLPHDIYAVG
460 470 480 490 500
TQDNPQGERE WAEHIRATLR TSTNIDYKQV AVQSLWNIRL AVFVKPEHEA
510 520 530 540 550
RISQVNTASV KTGLGNTLGN KGAVGVSLLF NGTSMGFVNC HLTSGSDKAL
560 570 580 590 600
RRNHNFQDIL RLLSLGEKQL STFDISLRFN HLFWCGDLNY RLDLDALDIL
610 620 630 640 650
KHVSKREFEE LMCADQLTRE RHKRKAFFNF KEEKIMFPPT YRYERGSRDC
660 670 680 690 700
YLWQKYKSSG VQVNGPSWCD RVLWKSYPES HVICTSYGCT DDIFTSEHSP
710 720 730 740 750
VFATFEVGVI SLFPRTESCS ERASIELEAI EAIVKTSSKA KFFIEFHSRC
760 770 780 790 800
LEEPRRSAEN DSQYCEVPGF LKLGWSSKQL PKLHPVFSDL EHLRDQHLLL
810 820 830 840 850
SVKSCDGFES YGECCVALRP TAGKLLDTFE TCLTHRGEEM GSIRGRFRVY
860 870 880 890 900
VPPDRRRIRE RVYEWLSIEK DEREMMKDQL SPPSSSAFSI KAPSASYVAS
910 920 930 940 950
PNSYTNPAYF IFEEMPVFRK AEEIPSTIKE SQVVCANNTV IQLPRVTGSH
960 970 980 990 1000
GHGKRSARRS DFTEIEIPGS LAPYKPSCET QSELSSAASS YQLFPGPHVP
1010 1020 1030 1040 1050
STSPNQRHTT HSSNSSLQLQ SHKNNMAPDS ELSGKKLTNS YMNHSVFSRD
1060 1070 1080 1090 1100
MHKEKVRQDY QGVHQGRPVP IRNGPKLYPY VSTRVPAQCS ASWIVEQPTP
1110 1120 1130 1140 1150
ASGDNSLTAL QIAKSLSEVD FQPADKKYPF HQMPSQQRQH GYDYGLASER
1160 1170 1180 1190 1200
NYSWEKEVSV LHGAPETVRE LLSTLGLQRY TLDLSRSGWD DLDYFSGITE
1210 1220
EELCAAGVSN PSHRRRILEN LPKIWD
Length:1,226
Mass (Da):137,320
Last modified:March 7, 2006 - v1
Checksum:i32C8C68DF2B80844
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1R4Y2F1R4Y2_DANRE
Phosphatidylinositol 3,4,5-trisphos...
inppl1b
1,124Annotation score:
A0A140LH62A0A140LH62_DANRE
Phosphatidylinositol 3,4,5-trisphos...
inppl1b
1,226Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272662 mRNA Translation: ABB84852.1
UniGeneiDr.159552
Dr.77998

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272662 mRNA Translation: ABB84852.1
UniGeneiDr.159552
Dr.77998

3D structure databases

ProteinModelPortaliQ2I6J0
SMRiQ2I6J0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096523

Proteomic databases

PaxDbiQ2I6J0
PRIDEiQ2I6J0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-030616-75 inppl1b

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
HOGENOMiHOG000004836
HOVERGENiHBG106726
InParanoidiQ2I6J0
PhylomeDBiQ2I6J0

Miscellaneous databases

PROiPR:Q2I6J0

Family and domain databases

Gene3Di3.30.505.10, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR000300 IPPc
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF55550 SSF55550, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHP2B_DANRE
AccessioniPrimary (citable) accession number: Q2I6J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 7, 2006
Last modified: November 22, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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