Vwf

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: VWFImported
Gene namesⁱ	Name:VwfImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:98941 Vwf

Keywords - Cellular componentⁱ

SecretedSAAS annotation

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_5004209660	23 – 2813	Sequence analysisAdd BLAST		2791

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	2724 ↔ 2774	PROSITE-ProRule annotation
Disulfide bondⁱ	2739 ↔ 2788	PROSITE-ProRule annotation
Disulfide bondⁱ	2750 ↔ 2804	PROSITE-ProRule annotation
Disulfide bondⁱ	2754 ↔ 2806	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRIDEⁱ	Q2I0J7

PRIDEⁱ

Q2I0J7

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	34 – 240	VWFDInterPro annotationAdd BLAST	207
Domainⁱ	387 – 598	VWFDInterPro annotationAdd BLAST	212
Domainⁱ	866 – 1074	VWFDInterPro annotationAdd BLAST	209
Domainⁱ	1277 – 1453	VWFAInterPro annotationAdd BLAST	177
Domainⁱ	1498 – 1665	VWFAInterPro annotationAdd BLAST	168
Domainⁱ	1691 – 1871	VWFAInterPro annotationAdd BLAST	181
Domainⁱ	1949 – 2153	VWFDInterPro annotationAdd BLAST	205
Domainⁱ	2255 – 2328	VWFCInterPro annotationAdd BLAST	74
Domainⁱ	2429 – 2495	VWFCInterPro annotationAdd BLAST	67
Domainⁱ	2580 – 2645	VWFCInterPro annotationAdd BLAST	66
Domainⁱ	2724 – 2812	CTCKInterPro annotationAdd BLAST	89

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IR8A Eukaryota ENOG41100RZ LUCA
HOVERGENⁱ	HBG004380

Family and domain databases

Gene3Dⁱ	3.40.50.410, 3 hits
InterProⁱ	View protein in InterPro IPR006207 Cys_knot_C IPR036084 Ser_inhib-like_sf IPR002919 TIL_dom IPR014853 Unchr_dom_Cys-rich IPR037578 Von_Willebrand_factor IPR032361 VWA_N2 IPR002035 VWF_A IPR001007 VWF_dom IPR001846 VWF_type-D IPR036465 vWFA_dom_sf
PANTHERⁱ	PTHR11339:SF361 PTHR11339:SF361, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08742 C8, 4 hits PF01826 TIL, 5 hits PF00092 VWA, 3 hits PF16164 VWA_N2, 1 hit PF00093 VWC, 2 hits PF00094 VWD, 4 hits
SMARTⁱ	View protein in SMART SM00832 C8, 4 hits SM00041 CT, 1 hit SM00327 VWA, 3 hits SM00214 VWC, 7 hits SM00215 VWC_out, 3 hits SM00216 VWD, 4 hits
SUPFAMⁱ	SSF53300 SSF53300, 3 hits SSF57567 SSF57567, 5 hits
PROSITEⁱ	View protein in PROSITE PS01185 CTCK_1, 1 hit PS01225 CTCK_2, 1 hit PS50234 VWFA, 3 hits PS01208 VWFC_1, 3 hits PS50184 VWFC_2, 3 hits PS51233 VWFD, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q2I0J7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNPFRYEICL LVLALTWPGA LCTEKPRDRP STARCSLFGD DFINTFDETM 
        60         70         80         90        100
YSFAGGCSYL LAGDCQKRSF SILGNFQDGK RMSLSVYLGE FFDIHLFANG 
       110        120        130        140        150
TVMQGDQSIS MPYASQGLYL EREAGYYKLS SETFGFAARI DGNGNFQVLM 
       160        170        180        190        200
SDRHFNKTCG LCGDFNIFAE DDFRTQEGTL TSDPYDFANS WALSSEEQRC 
       210        220        230        240        250
KRASPPSRNC ESSSGDMHQA MWEQCQLLKT ASVFARCHPL VDPESFVALC 
       260        270        280        290        300
EKTLCTCATG PECACPVLLE YARTCAQEGM VLYGWTDHSA CRPACPAGME 
       310        320        330        340        350
YKECVSPCPR TCQSLSINEV CQQQCVDGCS CPEGELLDED RCVQSSDCPC 
       360        370        380        390        400
VHAGKRYPPG TSLSQDCNTC ICRNSLWICS NEECPGECLV TGQSHFKSFD 
       410        420        430        440        450
NRYFTFSGIC QYLLARDCED HSFSIVIETM QCADDPDAVC TRSVSVRLSA 
       460        470        480        490        500
LHNSLVKLKH GGAVGIDGQD VQLPFLQGDL RIQHTVMASV RLSYAEDLQM 
       510        520        530        540        550
DWDGRGRLLV KLSPVYSGKT CGLCGNYNGN KGDDFLTPAG LVEPLVVDFG 
       560        570        580        590        600
NAWKLQGDCS DLRRQHSDPC SLNPRLTRFA EEACALLTSS KFEACHHAVS 
       610        620        630        640        650
PLPYLQNCRY DVCSCSDSRD CLCNAVANYA AECARKGVHI GWREPGFCAL 
       660        670        680        690        700
GCPQGQVYLQ CGNSCNLTCR SLSLPDEECS EVCLEGCYCP PGLYQDERGD 
       710        720        730        740        750
CVPKAQCPCY YDGELFQPAD IFSDHHTMCY CEDGFMHCTT SGTLGSLLPD 
       760        770        780        790        800
TVLSSPLSHR SKRSLSCRPP MVKLVCPADN PRAQGLECAK TCQNYDLECM 
       810        820        830        840        850
SLGCVSGCLC PPGMVRHENK CVALERCPCF HQGAEYAPGD TVKIGCNTCV 
       860        870        880        890        900
CRERKWNCTN HVCDATCSAI GMAHYLTFDG LKYLFPGECQ YVLVQDYCGS 
       910        920        930        940        950
NPGTFQILVG NEGCSYPSVK CRKRVTILVD GGELELFDGE VNVKRPLRDE 
       960        970        980        990       1000
SHFEVVESGR YVILLLGQAL SVVWDHHLSI SVVLKHTYQE QVCGLCGNFD 
      1010       1020       1030       1040       1050
GIQNNDFTTS SLQVEEDPVN FGNSWKVSSQ CADTRKLSLD VSPATCHNNI 
      1060       1070       1080       1090       1100
MKQTMVDSAC RILTSDVFQG CNRLVDPEPY LDICIYDTCS CESIGDCACF 
      1110       1120       1130       1140       1150
CDTIAAYAHV CAQHGQVVAW RTPTLCPQSC EEKNVRENGY ECEWRYNSCA 
      1160       1170       1180       1190       1200
PACPVTCQHP EPLACPVQCV EGCHAHCPPG RILDELLQTC VDPQDCPVCE 
      1210       1220       1230       1240       1250
VAGRRLAPGK KITLSPDDPA HCQNCHCDGV NLTCEACQEP GGLVAPPTDA 
      1260       1270       1280       1290       1300
PVSSTTPYVE DTPEPPLHNF YCSKLLDLVF LLDGSSMLSE AEFEVLKAFV 
      1310       1320       1330       1340       1350
VGMMERLHIS QKRIRVAVVE YHDGSRAYLE LKARKRPSEL RRITSQIKYT 
      1360       1370       1380       1390       1400
GSQVASTSEV LKYTLFQIFG KIDRPEASHI TLLLTASQEP PRMARNLVRY 
      1410       1420       1430       1440       1450
VQGLKKKKVI VIPVGIGPHA SLKQIRLIEK QAPENKAFLL SGVDELEQRR 
      1460       1470       1480       1490       1500
DEIVSYLCDL APEAPAPTQP PQVAHVTVSP GIAGISSPGP KRKSMVLDVV 
      1510       1520       1530       1540       1550
FVLEGSDEVG EANFNKSKEF VEEVIQRMDV SPDATRISVL QYSYTVTMEY 
      1560       1570       1580       1590       1600
AFNGAQSKEE VLRHVREIRY QGGNRTNTGQ ALQYLSEHSF SPSQGDRVEA 
      1610       1620       1630       1640       1650
PNLVYMVTGN PASDEIKRLP GDIQVVPIGV GPHANMQELE RISRPIAPIF 
      1660       1670       1680       1690       1700
IRDFETLPRE APDLVLQTCC SKEGLQLPTL PPLPDCSQPL DVVLLLDGSS 
      1710       1720       1730       1740       1750
SLPESSFDKM KSFAKAFISK ANIGPHLTQV SVIQYGSINT IDVPWNVVQE 
      1760       1770       1780       1790       1800
KAHLQSLVDL MQQEGGPSQI GDALAFAVRY VTSQIHGARP GASKAVVIII 
      1810       1820       1830       1840       1850
MDTSLDPVDT AADAARSNRV AVFPVGVGDR YDEAQLRILA GPGASSNVVK 
      1860       1870       1880       1890       1900
LQQVEDLSTM ATLGNSFFHK LCSGFSGVCV DEDGNEKRPG DVWTLPDQCH 
      1910       1920       1930       1940       1950
TVTCLANGQT LLQSHRVNCD HGPRPSCANS QSPVRVEETC GCRWTCPCVC 
      1960       1970       1980       1990       2000
TGSSTRHIVT FDGQNFKLTG SCSYVIFQNK EQDLEVLLHN GACSPGAKQA 
      2010       2020       2030       2040       2050
CMKSIEIKHA GVSAELHSNM EMAVDGRLVL APYVGENMEV SIYGAIMYEV 
      2060       2070       2080       2090       2100
RFTHLGHILT YTPQNNEFQL QLSPKTFASK MHGLCGICDE NGANDFTLRD 
      2110       2120       2130       2140       2150
GTVTTDWKRL VQEWTVQQPG YTCQAVPEEQ CPVSDSSHCQ VLLSASFAEC 
      2160       2170       2180       2190       2200
HKVIAPATFH TICQQDSCHQ ERVCEVIASY AHLCRTSGVC VDWRTTDFCA 
      2210       2220       2230       2240       2250
MSCPPSLVYN HCERGCPRHC DGNTSFCGDH PSEGCFCPQH QVFLEGSCVP 
      2260       2270       2280       2290       2300
EEACTQCVGE DGVRHQFLET WVPDHQPCQI CMCLSGRKIN CTAQPCPTAR 
      2310       2320       2330       2340       2350
APTCGPCEVA RLKQSTNLCC PEYECVCDLF NCNLPPVPPC EGGLQPTLTN 
      2360       2370       2380       2390       2400
PGECRPTFTC ACRKEECKRV SPPSCPPHRT PTLRKTQCCD EYECACSCVN 
      2410       2420       2430       2440       2450
STLSCPLGYL ASATTNDCGC TTTTCLPDKV CVHRGTVYPV GQFWEEGCDT 
      2460       2470       2480       2490       2500
CTCTDMEDTV VGLRVVQCSQ RPCEDSCQPG FSYVLHEGEC CGRCLPSACK 
      2510       2520       2530       2540       2550
VVAGSLRGDS HSSWKSVGSR WAVPENPCLV NECVRVEDAV FVQQRNISCP 
      2560       2570       2580       2590       2600
QLAVPTCPTG FQLNCETSEC CPSCHCEPVE ACLLNGTIIG PGKSVMVDLC 
      2610       2620       2630       2640       2650
TTCRCIVQTD AISRFKLECR KTTCEACPMG YREEKSQGEC CGRCLPTACT 
      2660       2670       2680       2690       2700
IQLRGGQIMT LKQDETFQDG CDSHLCRVNE RGEYIWEKRV TGCPPFDEHK 
      2710       2720       2730       2740       2750
CLAEGGKIVK IPGTCCDTCE EPDCKDITAK VQYIKVGDCK SQEEVDIHYC 
      2760       2770       2780       2790       2800
QGKCASKAVY SIDIEDVQEQ CSCCLPSRTE PMRVPLHCTN GSVVYHEVIN 
      2810 
AMQCRCSPRN CSK

Length:2,813

Mass (Da):309,102

Last modified:March 7, 2006 - v1

Checksum:ⁱ1EE7F131045D5B39

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ355288 mRNA Translation: ABC86574.1
UniGeneⁱ	Mm.22339

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q2I0J7	von Willebrand factor	)	MOUSE		2813	UniRef90_Q8CIZ8
von Willebrand factor		CRIGR		3099
von Willebrand factor-binding protein (Fragment)		Cricetulus barabensis ferrugineus		248
von Willebrand factor-binding protein (Fragment)		Cricetulus barabensis pseudogriseus		248
UPI000A30FD00		MUSPA		2816
+12

Protein	Similar proteins		Species	Score	Length	Source
Q2I0J7	von Willebrand factor	)	HUMAN		2813	UniRef50_P04275
von Willebrand factor (Fragment)		PIG		2482
von Willebrand factor	)	MOUSE		2813
von Willebrand factor		CANLF		2813
Uncharacterized protein		MACMU		2824
+157

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ355288 mRNA Translation: ABC86574.1
UniGeneⁱ	Mm.22339

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q2I0J7

PRIDEⁱ

Q2I0J7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MGIⁱ	MGI:98941 Vwf

Phylogenomic databases

eggNOGⁱ	ENOG410IR8A Eukaryota ENOG41100RZ LUCA
HOVERGENⁱ	HBG004380

Miscellaneous databases

ChiTaRSⁱ	Vwf mouse
SOURCEⁱ	Search...

Family and domain databases

Gene3Dⁱ	3.40.50.410, 3 hits
InterProⁱ	View protein in InterPro IPR006207 Cys_knot_C IPR036084 Ser_inhib-like_sf IPR002919 TIL_dom IPR014853 Unchr_dom_Cys-rich IPR037578 Von_Willebrand_factor IPR032361 VWA_N2 IPR002035 VWF_A IPR001007 VWF_dom IPR001846 VWF_type-D IPR036465 vWFA_dom_sf
PANTHERⁱ	PTHR11339:SF361 PTHR11339:SF361, 2 hits
Pfamⁱ	View protein in Pfam PF08742 C8, 4 hits PF01826 TIL, 5 hits PF00092 VWA, 3 hits PF16164 VWA_N2, 1 hit PF00093 VWC, 2 hits PF00094 VWD, 4 hits
SMARTⁱ	View protein in SMART SM00832 C8, 4 hits SM00041 CT, 1 hit SM00327 VWA, 3 hits SM00214 VWC, 7 hits SM00215 VWC_out, 3 hits SM00216 VWD, 4 hits
SUPFAMⁱ	SSF53300 SSF53300, 3 hits SSF57567 SSF57567, 5 hits
PROSITEⁱ	View protein in PROSITE PS01185 CTCK_1, 1 hit PS01225 CTCK_2, 1 hit PS50234 VWFA, 3 hits PS01208 VWFC_1, 3 hits PS50184 VWFC_2, 3 hits PS51233 VWFD, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q2I0J7_MOUSE
Accessionⁱ	Q2I0J7Primary (citable) accession number: Q2I0J7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 7, 2006
	Last sequence update:	March 7, 2006
	Last modified:	July 18, 2018
	This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q2I0J7 (Q2I0J7_MOUSE)

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Vwf

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Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

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Annotation systems

Supporting data

UniProtKB - Q2I0J7 (Q2I0J7_MOUSE)

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VWF

Vwf

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ