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Protein
Submitted name:

VWF

Gene

Vwf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
VWFImported
Gene namesi
Name:VwfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98941 Vwf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500420966023 – 2813Sequence analysisAdd BLAST2791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2724 ↔ 2774PROSITE-ProRule annotation
Disulfide bondi2739 ↔ 2788PROSITE-ProRule annotation
Disulfide bondi2750 ↔ 2804PROSITE-ProRule annotation
Disulfide bondi2754 ↔ 2806PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRIDEiQ2I0J7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 240VWFDInterPro annotationAdd BLAST207
Domaini387 – 598VWFDInterPro annotationAdd BLAST212
Domaini866 – 1074VWFDInterPro annotationAdd BLAST209
Domaini1277 – 1453VWFAInterPro annotationAdd BLAST177
Domaini1498 – 1665VWFAInterPro annotationAdd BLAST168
Domaini1691 – 1871VWFAInterPro annotationAdd BLAST181
Domaini1949 – 2153VWFDInterPro annotationAdd BLAST205
Domaini2255 – 2328VWFCInterPro annotationAdd BLAST74
Domaini2429 – 2495VWFCInterPro annotationAdd BLAST67
Domaini2580 – 2645VWFCInterPro annotationAdd BLAST66
Domaini2724 – 2812CTCKInterPro annotationAdd BLAST89

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR8A Eukaryota
ENOG41100RZ LUCA
HOVERGENiHBG004380

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 2 hits
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 5 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SUPFAMiSSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits

Sequencei

Sequence statusi: Complete.

Q2I0J7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPFRYEICL LVLALTWPGA LCTEKPRDRP STARCSLFGD DFINTFDETM
60 70 80 90 100
YSFAGGCSYL LAGDCQKRSF SILGNFQDGK RMSLSVYLGE FFDIHLFANG
110 120 130 140 150
TVMQGDQSIS MPYASQGLYL EREAGYYKLS SETFGFAARI DGNGNFQVLM
160 170 180 190 200
SDRHFNKTCG LCGDFNIFAE DDFRTQEGTL TSDPYDFANS WALSSEEQRC
210 220 230 240 250
KRASPPSRNC ESSSGDMHQA MWEQCQLLKT ASVFARCHPL VDPESFVALC
260 270 280 290 300
EKTLCTCATG PECACPVLLE YARTCAQEGM VLYGWTDHSA CRPACPAGME
310 320 330 340 350
YKECVSPCPR TCQSLSINEV CQQQCVDGCS CPEGELLDED RCVQSSDCPC
360 370 380 390 400
VHAGKRYPPG TSLSQDCNTC ICRNSLWICS NEECPGECLV TGQSHFKSFD
410 420 430 440 450
NRYFTFSGIC QYLLARDCED HSFSIVIETM QCADDPDAVC TRSVSVRLSA
460 470 480 490 500
LHNSLVKLKH GGAVGIDGQD VQLPFLQGDL RIQHTVMASV RLSYAEDLQM
510 520 530 540 550
DWDGRGRLLV KLSPVYSGKT CGLCGNYNGN KGDDFLTPAG LVEPLVVDFG
560 570 580 590 600
NAWKLQGDCS DLRRQHSDPC SLNPRLTRFA EEACALLTSS KFEACHHAVS
610 620 630 640 650
PLPYLQNCRY DVCSCSDSRD CLCNAVANYA AECARKGVHI GWREPGFCAL
660 670 680 690 700
GCPQGQVYLQ CGNSCNLTCR SLSLPDEECS EVCLEGCYCP PGLYQDERGD
710 720 730 740 750
CVPKAQCPCY YDGELFQPAD IFSDHHTMCY CEDGFMHCTT SGTLGSLLPD
760 770 780 790 800
TVLSSPLSHR SKRSLSCRPP MVKLVCPADN PRAQGLECAK TCQNYDLECM
810 820 830 840 850
SLGCVSGCLC PPGMVRHENK CVALERCPCF HQGAEYAPGD TVKIGCNTCV
860 870 880 890 900
CRERKWNCTN HVCDATCSAI GMAHYLTFDG LKYLFPGECQ YVLVQDYCGS
910 920 930 940 950
NPGTFQILVG NEGCSYPSVK CRKRVTILVD GGELELFDGE VNVKRPLRDE
960 970 980 990 1000
SHFEVVESGR YVILLLGQAL SVVWDHHLSI SVVLKHTYQE QVCGLCGNFD
1010 1020 1030 1040 1050
GIQNNDFTTS SLQVEEDPVN FGNSWKVSSQ CADTRKLSLD VSPATCHNNI
1060 1070 1080 1090 1100
MKQTMVDSAC RILTSDVFQG CNRLVDPEPY LDICIYDTCS CESIGDCACF
1110 1120 1130 1140 1150
CDTIAAYAHV CAQHGQVVAW RTPTLCPQSC EEKNVRENGY ECEWRYNSCA
1160 1170 1180 1190 1200
PACPVTCQHP EPLACPVQCV EGCHAHCPPG RILDELLQTC VDPQDCPVCE
1210 1220 1230 1240 1250
VAGRRLAPGK KITLSPDDPA HCQNCHCDGV NLTCEACQEP GGLVAPPTDA
1260 1270 1280 1290 1300
PVSSTTPYVE DTPEPPLHNF YCSKLLDLVF LLDGSSMLSE AEFEVLKAFV
1310 1320 1330 1340 1350
VGMMERLHIS QKRIRVAVVE YHDGSRAYLE LKARKRPSEL RRITSQIKYT
1360 1370 1380 1390 1400
GSQVASTSEV LKYTLFQIFG KIDRPEASHI TLLLTASQEP PRMARNLVRY
1410 1420 1430 1440 1450
VQGLKKKKVI VIPVGIGPHA SLKQIRLIEK QAPENKAFLL SGVDELEQRR
1460 1470 1480 1490 1500
DEIVSYLCDL APEAPAPTQP PQVAHVTVSP GIAGISSPGP KRKSMVLDVV
1510 1520 1530 1540 1550
FVLEGSDEVG EANFNKSKEF VEEVIQRMDV SPDATRISVL QYSYTVTMEY
1560 1570 1580 1590 1600
AFNGAQSKEE VLRHVREIRY QGGNRTNTGQ ALQYLSEHSF SPSQGDRVEA
1610 1620 1630 1640 1650
PNLVYMVTGN PASDEIKRLP GDIQVVPIGV GPHANMQELE RISRPIAPIF
1660 1670 1680 1690 1700
IRDFETLPRE APDLVLQTCC SKEGLQLPTL PPLPDCSQPL DVVLLLDGSS
1710 1720 1730 1740 1750
SLPESSFDKM KSFAKAFISK ANIGPHLTQV SVIQYGSINT IDVPWNVVQE
1760 1770 1780 1790 1800
KAHLQSLVDL MQQEGGPSQI GDALAFAVRY VTSQIHGARP GASKAVVIII
1810 1820 1830 1840 1850
MDTSLDPVDT AADAARSNRV AVFPVGVGDR YDEAQLRILA GPGASSNVVK
1860 1870 1880 1890 1900
LQQVEDLSTM ATLGNSFFHK LCSGFSGVCV DEDGNEKRPG DVWTLPDQCH
1910 1920 1930 1940 1950
TVTCLANGQT LLQSHRVNCD HGPRPSCANS QSPVRVEETC GCRWTCPCVC
1960 1970 1980 1990 2000
TGSSTRHIVT FDGQNFKLTG SCSYVIFQNK EQDLEVLLHN GACSPGAKQA
2010 2020 2030 2040 2050
CMKSIEIKHA GVSAELHSNM EMAVDGRLVL APYVGENMEV SIYGAIMYEV
2060 2070 2080 2090 2100
RFTHLGHILT YTPQNNEFQL QLSPKTFASK MHGLCGICDE NGANDFTLRD
2110 2120 2130 2140 2150
GTVTTDWKRL VQEWTVQQPG YTCQAVPEEQ CPVSDSSHCQ VLLSASFAEC
2160 2170 2180 2190 2200
HKVIAPATFH TICQQDSCHQ ERVCEVIASY AHLCRTSGVC VDWRTTDFCA
2210 2220 2230 2240 2250
MSCPPSLVYN HCERGCPRHC DGNTSFCGDH PSEGCFCPQH QVFLEGSCVP
2260 2270 2280 2290 2300
EEACTQCVGE DGVRHQFLET WVPDHQPCQI CMCLSGRKIN CTAQPCPTAR
2310 2320 2330 2340 2350
APTCGPCEVA RLKQSTNLCC PEYECVCDLF NCNLPPVPPC EGGLQPTLTN
2360 2370 2380 2390 2400
PGECRPTFTC ACRKEECKRV SPPSCPPHRT PTLRKTQCCD EYECACSCVN
2410 2420 2430 2440 2450
STLSCPLGYL ASATTNDCGC TTTTCLPDKV CVHRGTVYPV GQFWEEGCDT
2460 2470 2480 2490 2500
CTCTDMEDTV VGLRVVQCSQ RPCEDSCQPG FSYVLHEGEC CGRCLPSACK
2510 2520 2530 2540 2550
VVAGSLRGDS HSSWKSVGSR WAVPENPCLV NECVRVEDAV FVQQRNISCP
2560 2570 2580 2590 2600
QLAVPTCPTG FQLNCETSEC CPSCHCEPVE ACLLNGTIIG PGKSVMVDLC
2610 2620 2630 2640 2650
TTCRCIVQTD AISRFKLECR KTTCEACPMG YREEKSQGEC CGRCLPTACT
2660 2670 2680 2690 2700
IQLRGGQIMT LKQDETFQDG CDSHLCRVNE RGEYIWEKRV TGCPPFDEHK
2710 2720 2730 2740 2750
CLAEGGKIVK IPGTCCDTCE EPDCKDITAK VQYIKVGDCK SQEEVDIHYC
2760 2770 2780 2790 2800
QGKCASKAVY SIDIEDVQEQ CSCCLPSRTE PMRVPLHCTN GSVVYHEVIN
2810
AMQCRCSPRN CSK
Length:2,813
Mass (Da):309,102
Last modified:March 7, 2006 - v1
Checksum:i1EE7F131045D5B39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355288 mRNA Translation: ABC86574.1
UniGeneiMm.22339

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355288 mRNA Translation: ABC86574.1
UniGeneiMm.22339

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2I0J7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98941 Vwf

Phylogenomic databases

eggNOGiENOG410IR8A Eukaryota
ENOG41100RZ LUCA
HOVERGENiHBG004380

Miscellaneous databases

ChiTaRSiVwf mouse
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 2 hits
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 5 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SUPFAMiSSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ2I0J7_MOUSE
AccessioniPrimary (citable) accession number: Q2I0J7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: July 18, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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