Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 49 (29 Sep 2021)
Sequence version 1 (07 Mar 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Pro-interleukin-16

Gene

IL16

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokineUniRule annotationARBA annotation
Biological processChemotaxisUniRule annotationARBA annotation, Transcription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-interleukin-16UniRule annotation
Cleaved into the following chain:
Interleukin-16UniRule annotation
Short name:
IL-16UniRule annotation
Alternative name(s):
Lymphocyte chemoattractant factorUniRule annotation
Short name:
LCFUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL16UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation, SecretedUniRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

UniRule annotation

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini179 – 265PDZInterPro annotationAdd BLAST87
Domaini323 – 393PDZInterPro annotationAdd BLAST71
Domaini1069 – 1153PDZInterPro annotationAdd BLAST85
Domaini1181 – 1261PDZInterPro annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45DisorderedSequence analysisAdd BLAST45
Regioni63 – 103DisorderedSequence analysisAdd BLAST41
Regioni562 – 634DisorderedSequence analysisAdd BLAST73
Regioni666 – 694DisorderedSequence analysisAdd BLAST29
Regioni709 – 783DisorderedSequence analysisAdd BLAST75
Regioni801 – 932DisorderedSequence analysisAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 42Polar residuesSequence analysisAdd BLAST25
Compositional biasi76 – 93Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi562 – 590Polar residuesSequence analysisAdd BLAST29
Compositional biasi609 – 624Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi747 – 765Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi811 – 829Polar residuesSequence analysisAdd BLAST19
Compositional biasi846 – 874Polar residuesSequence analysisAdd BLAST29
Compositional biasi892 – 906Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi907 – 929Polar residuesSequence analysisAdd BLAST23

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020450, IL-16
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01931, INTRLEUKIN16

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HYY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQSKSFGHE DQGKRSSFKG RMTQNCFCPP PLPQQFLQTQ RPSPLGFGPA
60 70 80 90 100
GRSFVLAKMT AMPQRYSHQR RRTSTAAAAR RMEKRRREQG KNNSLTSDHN
110 120 130 140 150
SYRSRKLSML SRAADNTHWS KPQPSTAENT HNLVHRTASV RENKRSIRRS
160 170 180 190 200
FSVKPVQRSF SSAHLMNSCS NVQAFIIGTV VLMKGHGKGL GFSIVGGQDS
210 220 230 240 250
MYGPMGIYVK TIFPGGAAAA DGRLQEGDEI LEVNGESLHG LTHDEALHKF
260 270 280 290 300
KQVRKGLLTL VVRTSLRLGT LCGPTQLCRS RSLCSTADMA RDNTDLENYL
310 320 330 340 350
NNNCSNTLSL SGPPTNRDRI IMEMVLQKEA GVGLGIGLCC VPSGEGCPRI
360 370 380 390 400
YIHTFSPGSV AHMDGRLRYG DEIIEINDTV VYNMALNDVY TVLSQCTPGP
410 420 430 440 450
VHIIISRHPN PKVSEEQLND AIAQAVENSK LRKDKNQWSA NGMQRFYTHS
460 470 480 490 500
RHKCETCVDR SFSQQTIHHG QRIMTRSCSD STNSHHHHNR CVRTHNLQHY
510 520 530 540 550
HHSPSARVHS LDVPKSETWP ENRLSVPVYP DEEYNIPYSC PSASATCQRN
560 570 580 590 600
VNFTFSKFSC NGSPGPHQIS RTDMDLSTED GYTGDSSGSS RESPIRHRRL
610 620 630 640 650
APSSRGVCKQ GERLKEDSPE SKDSAHPESA VGAEIPTGDS LVVVCSQPKR
660 670 680 690 700
GALRRQVCVD QHQDPWVRHS DTSPEELPKA QHCPVGSPRP ENICSKPPIM
710 720 730 740 750
TESEKLPILD DSVEPPEPLS DVTLAEFPSG AKKGPPVAPK PPWFRQSLKK
760 770 780 790 800
IQDERERKKT DKPAAQKPHV GFSRSFGGRS GSSAANLSIK QKIHSFETFS
810 820 830 840 850
TPAAPEMVEN KKPTSVSSFC PPVESKSHSG SINNKKDEVP EEIQANPPPS
860 870 880 890 900
ASTINPSTSE GQPQHPQEQP VSNQEPRDLV VADLDSGSND AVSSPDHDER
910 920 930 940 950
NTSPSEQEPE TEGSAVSPSA TSLRPSEGLA NSPQVDIEMD GALNGNQLQK
960 970 980 990 1000
DLDGENLEKI LTLSNQVSQA LMHSLAMQPR HDSKRPPSPE DTSCVDFTSE
1010 1020 1030 1040 1050
SAPTSFSVSL AALRECITEQ GELELEDKTR SASIQAAVSA IPSDRMQSVV
1060 1070 1080 1090 1100
QEMQTLEDDT LKQLEDIHLV VLHKDEGIGL GFSIAGGSDL ENKVLTVHKV
1110 1120 1130 1140 1150
FSSGLAAQEG TIEKGDEVLS INGQILRGLT HAEATAALRQ TRNLMLAVVV
1160 1170 1180 1190 1200
VGKQAEAEGA KEGRSMDESG VTVEVQGGPI TVKIIKGAAG VGFTLEGGKG
1210 1220 1230 1240 1250
SIHGDRPLVI NRIFTDDDAL KMGDVLLQVQ DVSVQEMTRF EAWNLVKSLP
1260
EGPVTVVIAR KTGAAE
Length:1,266
Mass (Da):138,208
Last modified:March 7, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8919C1CB131C4920
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ362884 mRNA Translation: ABC87741.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ362884 mRNA Translation: ABC87741.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.30.42.10, 4 hits
InterProiView protein in InterPro
IPR020450, IL-16
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF00595, PDZ, 3 hits
PRINTSiPR01931, INTRLEUKIN16
SMARTiView protein in SMART
SM00228, PDZ, 4 hits
SUPFAMiSSF50156, SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2HYY2_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2HYY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 29, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again