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Entry version 107 (03 Jul 2019)
Sequence version 1 (21 Mar 2006)
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Protein
Submitted name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Gene

abcc9

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi623 – 630ATPPROSITE-ProRule annotation8
Nucleotide bindingi1166 – 1173ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette, sub-family C (CFTR/MRP), member 9Imported
Submitted name:
Sulfonylurea receptor subunit 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcc9Imported
Synonyms:zSUR2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050517-23 abcc9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 60HelicalSequence analysisAdd BLAST24
Transmembranei81 – 102HelicalSequence analysisAdd BLAST22
Transmembranei265 – 282HelicalSequence analysisAdd BLAST18
Transmembranei342 – 368HelicalSequence analysisAdd BLAST27
Transmembranei374 – 392HelicalSequence analysisAdd BLAST19
Transmembranei458 – 479HelicalSequence analysisAdd BLAST22
Transmembranei491 – 514HelicalSequence analysisAdd BLAST24
Transmembranei856 – 877HelicalSequence analysisAdd BLAST22
Transmembranei944 – 969HelicalSequence analysisAdd BLAST26
Transmembranei1045 – 1061HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000015985 Expressed in 15 organ(s), highest expression level in heart

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 515ABC transmembrane type-1InterPro annotationAdd BLAST296
Domaini590 – 790ABC transporterInterPro annotationAdd BLAST201
Domaini916 – 1093ABC transmembrane type-1InterPro annotationAdd BLAST178
Domaini1132 – 1366ABC transporterInterPro annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni826 – 850DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi830 – 844AcidicSequence analysisAdd BLAST15

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156680

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR001475 ABCC9
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF173 PTHR24223:SF173, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q2HX28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSFCGNDR DSNAYSVDNG VLDNGCFVDA LNLVPHVFLL FITFPILFIA
60 70 80 90 100
LFIYWILAFI TKMIKLWKFA EASLGVQHLR FCITALLVVL YGLLMAVEIN
110 120 130 140 150
VIRVRKYVFF ANPQRVKPPE DLQDLGVRFL QPFVNLLSKA TYWWMNPLII
160 170 180 190 200
GAHKRPIELK KIGKLPIAMR ALTNYLRLKD SYEEQRQNTE DPEKSPSIWK
210 220 230 240 250
SMYRAFGGSI LLSSTFRYMA DLLGFAGPLC ISGIVEHLHN STEIDRTNKT
260 270 280 290 300
GNMTFGVYFM SSTELLQNTS VLAVLLFLAL VLQRTFLQAS YYVTIETGIN
310 320 330 340 350
LRGALLAMIY NKILRLSTSN MSMGEMTLGQ INNLVAIETN QLMWFLFLCP
360 370 380 390 400
NLWAMPVQII MGVILLYYLL GNSALIGAGV ILLLAPVQYL IATKLADIQK
410 420 430 440 450
STLDYSTDRL KKTTEILKGI KLLKLYAWEN IFCDRVEETR GKELTSLKTF
460 470 480 490 500
ALHTSMSIFM NAAIPIAAVL ATFVTHAYIE EDRLSPAKAF ASLALFHILV
510 520 530 540 550
TPLFLLSTVV RFAVKALVSV QKLSEFLQSD EIGDDSWRNG DMCMSLEVGK
560 570 580 590 600
KYKYQGDTKA INRKGRYRMD NYEQPVRRQL RPSETEDVAV QVNDGFFTWG
610 620 630 640 650
SNLSTLSDIN IRIPTGQLTM IVGQVGCGKS SLLLAMLGEM QTISGKVYWS
660 670 680 690 700
NKNRYSVAYA TQKSWLLNAT VEENITFGSP FNKQRYKAVI DACSLQPDID
710 720 730 740 750
LLPFGDQTEI GERDDPFSAL DIHLSDHLMQ EGILKFLQDD KRTVVLVTHK
760 770 780 790 800
LQYLIHADWI IAMKDGSVLR EGTLKDIQTH DVELYEHWKT LMNRQDQELE
810 820 830 840 850
KDTDLESQTT LERKTLRRAF YSREAKNHVD DEDEEEEVEE EDDDNMSTTT
860 870 880 890 900
SRRSKIPWKM CCCYLSSGGF LMVFLMVSSK LAKHSVMVAI DYWLAAWTSS
910 920 930 940 950
NPHNQSFVNS SFNHTLNDDA TQIAEHIPPT LESLTRSTLL CLSAIGVIAF
960 970 980 990 1000
VTPAFLIALV PLAVAFYFIQ KYFRVASKDL QELDDSTQLP LLCHFSETAE
1010 1020 1030 1040 1050
GLTTIRAFRH EARFKQRMLE LTDTNNTAYL FLSAANRWLE VRTDYLGAVI
1060 1070 1080 1090 1100
VLTAAVAAIW STSPSGLVGL GLTYALTLTN YLNWVVRNLA DLEVQMAAVK
1110 1120 1130 1140 1150
KVNSFLSTES ENYEGSMDVS QVPEDWPQHG EITIHDLCVR YDSMLKPVLK
1160 1170 1180 1190 1200
HVNAHINPGQ KVGICGRTGS GKSSLSLAFF NMVDVFEGKI VIDGIDICKL
1210 1220 1230 1240 1250
PLQTLRSRLS IILQDPVLFS GSIRLNLDPE RTCTDDRLWE ALEIAQLKNM
1260 1270 1280 1290 1300
VKALPGGLDA VVTEGGENFS VGQRQLFCLA RAFVRKSSIL IMDEATASID
1310 1320 1330 1340 1350
MATENILQKV VMTAFADRTV VTIAHLVSSI LEAEQVLVFS SGILVENDSA
1360 1370 1380 1390 1400
INLLAQEDSL FGILHRVHTI LTADLVIVMK RGSIMEYEKP EILMEQEDGL

FASFVKADM
Length:1,409
Mass (Da):158,535
Last modified:March 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9804BC81437BBA04
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5RH87Q5RH87_DANRE
ATP-binding cassette, sub-family C ...
abcc9
1,558Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IAS5A0A0R4IAS5_DANRE
ATP-binding cassette, sub-family C ...
abcc9
1,557Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX571719 Genomic DNA No translation available.
AB231937 mRNA Translation: BAE79477.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000079987; ENSDARP00000074437; ENSDARG00000015985

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571719 Genomic DNA No translation available.
AB231937 mRNA Translation: BAE79477.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000079987; ENSDARP00000074437; ENSDARG00000015985

Organism-specific databases

ZFINiZDB-GENE-050517-23 abcc9

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000156680

Gene expression databases

BgeeiENSDARG00000015985 Expressed in 15 organ(s), highest expression level in heart

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR001475 ABCC9
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF173 PTHR24223:SF173, 3 hits
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2HX28_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2HX28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: July 3, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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