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Protein

E3 SUMO-protein ligase K-bZIP

Gene

K8

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in viral gene regulation and seems to be essential for KSHV reactivation. Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 AND RB1.4 Publications

Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell cycle by virus, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00886

Names & Taxonomyi

Protein namesi
Recommended name:
E3 SUMO-protein ligase K-bZIP (EC:2.3.2.-)
Alternative name(s):
E3 SUMO-protein transferase K-bZIPCurated
Gene namesi
Name:K8
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004238461 – 286E3 SUMO-protein ligase K-bZIPAdd BLAST286

Post-translational modificationi

Sumoylated.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ2HR82

Interactioni

Subunit structurei

Interacts with host HDAC1 and HDAC2, these interactions suppress HDAC activities. Interacts with protein ORF57. Interacts with protein vPK (PubMed:17108053).3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi1776965, 21 interactors
IntActiQ2HR82, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ2HR82
SMRiQ2HR82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK21655

Family and domain databases

InterProiView protein in InterPro
IPR010805 KSHV_K8
PfamiView protein in Pfam
PF07188 KSHV_K8, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HR82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRMKDIPTK SSPGTDNSEK DEAVIEEDLS LNGQPFFTDN TDGGENEVSW
60 70 80 90 100
TSSLLSTYVG CQPPAIPVCE TVIDLTAPSQ SGAPGDEHLP CSLNAETKFH
110 120 130 140 150
IPDPSWTLSH TPPRGPHISQ QLPTRRSKRR LHRKFEEERL CTKAKQGAGR
160 170 180 190 200
PVPASVVKVG NITPHYGEEL TRGDAVPAAP ITPPYPRVQR PAQPTHVLFS
210 220 230 240 250
PVFVSLKAEV CDQSHSPTRK QGRYGRVSSK AYTRQLQQAL EEKDAQLCFL
260 270 280
AARLEAHKEQ IIFLRDMLMR MCQQPASPTD APLPPC
Length:286
Mass (Da):31,574
Last modified:March 21, 2006 - v1
Checksum:i69FE9D78A4BB4FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA Translation: ABD28901.1
RefSeqiYP_001129403.1, NC_009333.1

Genome annotation databases

GeneIDi4961462
KEGGivg:4961462

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA Translation: ABD28901.1
RefSeqiYP_001129403.1, NC_009333.1

3D structure databases

ProteinModelPortaliQ2HR82
SMRiQ2HR82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1776965, 21 interactors
IntActiQ2HR82, 6 interactors

Proteomic databases

PRIDEiQ2HR82

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4961462
KEGGivg:4961462

Phylogenomic databases

KOiK21655

Enzyme and pathway databases

UniPathwayi
UPA00886

Family and domain databases

InterProiView protein in InterPro
IPR010805 KSHV_K8
PfamiView protein in Pfam
PF07188 KSHV_K8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKBZIP_HHV8P
AccessioniPrimary (citable) accession number: Q2HR82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: March 21, 2006
Last modified: July 18, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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