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Protein

Autophagy-related protein 101

Gene

ATG101

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.By similarity

GO - Molecular functioni

GO - Biological processi

  • autophagosome assembly Source: GO_Central

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-BTA-1632852 Macroautophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 101
Gene namesi
Name:ATG101
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:26249 ATG101

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943211 – 218Autophagy-related protein 101Add BLAST218

Proteomic databases

PaxDbiQ2HJE0
PRIDEiQ2HJE0

Expressioni

Gene expression databases

BgeeiENSBTAG00000000510 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000651

Structurei

3D structure databases

SMRiQ2HJE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Important for interaction with ATG13By similarity5

Sequence similaritiesi

Belongs to the ATG101 family.Curated

Phylogenomic databases

eggNOGiKOG4493 Eukaryota
ENOG410XP6A LUCA
GeneTreeiENSGT00390000016511
HOGENOMiHOG000008086
InParanoidiQ2HJE0
KOiK19730
OMAiIDCDFID
OrthoDBiEOG091G076X
TreeFamiTF320996

Family and domain databases

InterProiView protein in InterPro
IPR012445 ATG101
PANTHERiPTHR13292 PTHR13292, 1 hit
PfamiView protein in Pfam
PF07855 ATG101, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HJE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV
60 70 80 90 100
GTQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFRDALRNS GGDGLGQMSL
110 120 130 140 150
EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE
160 170 180 190 200
KIINIVEVMN RHEYLPKMPT QSEVDNVFDT GLRDVQPYLY KISFQITDAL
210
GSSVTTTMRR LIKDTLAL
Length:218
Mass (Da):25,017
Last modified:March 21, 2006 - v1
Checksum:i7395D1EAE69D7E54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105530 mRNA Translation: AAI05531.1
RefSeqiNP_001039599.1, NM_001046134.1
XP_005206266.1, XM_005206209.3
XP_005206267.1, XM_005206210.3
UniGeneiBt.5191

Genome annotation databases

EnsembliENSBTAT00000000651; ENSBTAP00000000651; ENSBTAG00000000510
GeneIDi513049
KEGGibta:513049

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105530 mRNA Translation: AAI05531.1
RefSeqiNP_001039599.1, NM_001046134.1
XP_005206266.1, XM_005206209.3
XP_005206267.1, XM_005206210.3
UniGeneiBt.5191

3D structure databases

SMRiQ2HJE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000651

Proteomic databases

PaxDbiQ2HJE0
PRIDEiQ2HJE0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000651; ENSBTAP00000000651; ENSBTAG00000000510
GeneIDi513049
KEGGibta:513049

Organism-specific databases

CTDi60673
VGNCiVGNC:26249 ATG101

Phylogenomic databases

eggNOGiKOG4493 Eukaryota
ENOG410XP6A LUCA
GeneTreeiENSGT00390000016511
HOGENOMiHOG000008086
InParanoidiQ2HJE0
KOiK19730
OMAiIDCDFID
OrthoDBiEOG091G076X
TreeFamiTF320996

Enzyme and pathway databases

ReactomeiR-BTA-1632852 Macroautophagy

Gene expression databases

BgeeiENSBTAG00000000510 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR012445 ATG101
PANTHERiPTHR13292 PTHR13292, 1 hit
PfamiView protein in Pfam
PF07855 ATG101, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATGA1_BOVIN
AccessioniPrimary (citable) accession number: Q2HJE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 21, 2006
Last modified: September 12, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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