Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dysbindin

Gene

DTNBP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dysbindin
Alternative name(s):
Biogenesis of lysosome-related organelles complex 1 subunit 8
Short name:
BLOC-1 subunit 8
Dysbindin-1
Dystrobrevin-binding protein 1
Gene namesi
Name:DTNBP1
Synonyms:BLOC1S8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002672091 – 342DysbindinAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by TRIM32. Ubiquitination leads to DTNBP1 degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ2HJA5
PRIDEiQ2HJA5

Interactioni

Subunit structurei

Interacts (via its coiled coil domain) with KXD1. Interacts with CMYA5, PI4K2 and RNF151 (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of at least BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly in the complex with BLOC1S5, BLOC1S6 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. This BLOC-1 complex also associates with the BLOC-2 complex in endosomes. Binds to DTNA and DTNB but may not be a physiological binding partner Interacts with the DNA-dependent protein kinase complex DNA-PK; the interaction phosphorylates DTNBP1 in vitro. Interacts directly in this complex with XRCC5 and XRCC6. Interacts with AP3M1, AP3B2 and TRIM32. Interacts with XPO1; the interaction exports DTNBP1 out of the nucleus (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051067

Structurei

3D structure databases

SMRiQ2HJA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 180Sequence analysisAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi243 – 256Nuclear export signalBy similarityAdd BLAST14

Sequence similaritiesi

Belongs to the dysbindin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9S Eukaryota
ENOG4111YM1 LUCA
HOGENOMiHOG000272621
HOVERGENiHBG051416
InParanoidiQ2HJA5
KOiK20189

Family and domain databases

InterProiView protein in InterPro
IPR007531 Dysbindin
PANTHERiPTHR16294 PTHR16294, 1 hit
PfamiView protein in Pfam
PF04440 Dysbindin, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HJA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLETLRERLL SVQQDFTSGL KTLSDKSREA KAKNKPRTVP CLPKYSAGLE
60 70 80 90 100
LLSRYEDTWA ALHRRAKECA SAGERVDSEV VMLSAHWEKK QASLRDLQQQ
110 120 130 140 150
LQQLPGLIAD LESLTASLTH LEASFEEVEN HLLNLEDLCG QCELERHKHM
160 170 180 190 200
QSQQLENYKK NKRKELETFK AELDAEHSQK VLEMEQTQQL KLKERQKFFE
210 220 230 240 250
EAFQQDMEQY LSTGYLQIAE RREPMGSMSS MEVNVDMLEQ MDLMDISDQE
260 270 280 290 300
ALDVFLNSGG EENTLLSPIS GPEASPGQDA VTLQVPTPSQ APATPPSSSS
310 320 330 340
PGTDPASRDP SEGGESPVVQ SDEEGVEVDT ALATLHSDDS DS
Length:342
Mass (Da):38,207
Last modified:March 21, 2006 - v1
Checksum:iA22BEF406CF5DB92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113232 mRNA Translation: AAI13233.1
RefSeqiNP_001039412.1, NM_001045947.1
UniGeneiBt.38575

Genome annotation databases

GeneIDi506612
KEGGibta:506612

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113232 mRNA Translation: AAI13233.1
RefSeqiNP_001039412.1, NM_001045947.1
UniGeneiBt.38575

3D structure databases

SMRiQ2HJA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051067

Proteomic databases

PaxDbiQ2HJA5
PRIDEiQ2HJA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi506612
KEGGibta:506612

Organism-specific databases

CTDi84062

Phylogenomic databases

eggNOGiENOG410IF9S Eukaryota
ENOG4111YM1 LUCA
HOGENOMiHOG000272621
HOVERGENiHBG051416
InParanoidiQ2HJA5
KOiK20189

Family and domain databases

InterProiView protein in InterPro
IPR007531 Dysbindin
PANTHERiPTHR16294 PTHR16294, 1 hit
PfamiView protein in Pfam
PF04440 Dysbindin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDTBP1_BOVIN
AccessioniPrimary (citable) accession number: Q2HJA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again