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Protein

Palmitoyltransferase ZDHHC6

Gene

ZDHHC6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC6By similarity (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 6By similarity
Short name:
DHHC-6By similarity
Gene namesi
Name:ZDHHC6By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Organism-specific databases

VGNCiVGNC:37144 ZDHHC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692271 – 413Palmitoyltransferase ZDHHC6Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi328S-palmitoyl cysteineBy similarity1
Lipidationi329S-palmitoyl cysteineBy similarity1
Lipidationi343S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated at 3 different sites by ZDHHC16. The combination of the different palmitoylation events strongly affects the quaternary assembly of ZDHHC6, its localization, stability and function. Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6. Depalmitoylated by LYPLA2.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ2HJ95
PRIDEiQ2HJ95

Expressioni

Gene expression databases

BgeeiENSBTAG00000006713

Interactioni

Subunit structurei

Homooligomerizes. Interacts with SELENOK.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008828

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 149DHHCPROSITE-ProRule annotationAdd BLAST51
Domaini313 – 398SH3PROSITE-ProRule annotationAdd BLAST86

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi410 – 413Di-lysine motifBy similarity4

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity
The C-terminal di-lysine motif confers endoplasmic reticulum localization.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1314 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00900000140969
HOGENOMiHOG000017896
HOVERGENiHBG054221
InParanoidiQ2HJ95
KOiK20031
OMAiWFPRRCV
OrthoDBiEOG091G0HOK
TreeFamiTF320809

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR001452 SH3_domain
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PF07653 SH3_2, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HJ95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTFCSVVKF ENLQELKRLC HWGPIIALGV IAICSAMAMI DSVLWYWPLH
60 70 80 90 100
TTGGSVNFIM LINWTVMILY NYFNAMFVGP GFVPLGWKPE NSQDSVYLQY
110 120 130 140 150
CKVCQAYKAP RSHHCRKCNR CVMKMDHHCP WINNCCGYQN HASFTLFLLL
160 170 180 190 200
APLGCIHAAF IFVMTMYTQL YNRLSFGWNT VKIDMSAARR DPLPIIPFGL
210 220 230 240 250
AAFAATLFAL GLALGTTIAV GMLFFIQMKI ILRNKTSIES WIEEKAKDRI
260 270 280 290 300
QYYQLDEVFV FPYDMGSRWK NFKQVFTWSG VPEGDGLDWP IREGCHQYSL
310 320 330 340 350
TIEQLKQKAD KRVRSVRYKV IEDYSGTCCP LNRGIKTFFT SPCTEEPRIR
360 370 380 390 400
LQKGEFILAT RGLRYWLYGD KILDDSVLEG VSRIRGWFPR NCVEKCPCDA
410
ETDQAPEGEK KNR
Length:413
Mass (Da):47,531
Last modified:March 21, 2006 - v1
Checksum:i76DD8EDA86EE57BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113243 mRNA Translation: AAI13244.1
RefSeqiNP_001039632.1, NM_001046167.1
UniGeneiBt.6696

Genome annotation databases

EnsembliENSBTAT00000008828; ENSBTAP00000008828; ENSBTAG00000006713
GeneIDi514158
KEGGibta:514158

Similar proteinsi

Entry informationi

Entry nameiZDHC6_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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