UniProtKB - Q2HJ86 (TBA1D_BOVIN)
Tubulin alpha-1D chain
TUBA1D
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 452 | Involved in polymerizationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 142 – 148 | GTPSequence analysis | 7 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: GO_Central
- structural constituent of cytoskeleton Source: GO_Central
GO - Biological processi
- microtubule cytoskeleton organization Source: GO_Central
- mitotic cell cycle Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin alpha-1D chainCleaved into the following chain: |
Gene namesi | Name:TUBA1D |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- microtubule Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288849 | 1 – 452 | Tubulin alpha-1D chainAdd BLAST | 452 | |
ChainiPRO_0000437391 | 1 – 448 | Detyrosinated tubulin alpha-1D chainBy similarityAdd BLAST | 448 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 282 | 3'-nitrotyrosineBy similarity | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Modified residuei | 446 | 5-glutamyl polyglutamateBy similarity | 1 | |
Modified residuei | 452 | 3'-nitrotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Nitration, PhosphoproteinProteomic databases
PaxDbi | Q2HJ86 |
PeptideAtlasi | Q2HJ86 |
PRIDEi | Q2HJ86 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000030973, Expressed in lung and 11 other tissues |
ExpressionAtlasi | Q2HJ86, baseline and differential |
Interactioni
Subunit structurei
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000038183 |
Structurei
Secondary structure
3D structure databases
SMRi | Q2HJ86 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q2HJ86 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1376, Eukaryota |
GeneTreei | ENSGT00950000182825 |
HOGENOMi | CLU_015718_0_0_1 |
InParanoidi | Q2HJ86 |
OMAi | HQRECIS |
OrthoDBi | 514396at2759 |
TreeFami | TF300314 |
Family and domain databases
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002452, Alpha_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR037103, Tubulin/FtsZ_C_sf IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01162, ALPHATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MRECISVHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN
60 70 80 90 100
TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA
110 120 130 140 150
NNYARGHYTI GKELIDLVLD RIRKLADQCT GLQGFLIFHS FGGGTGSGFT
160 170 180 190 200
SLLMERLSVD YGKKSKLEFS IYPAPQVSTA VVEPYNSILT THTTLEHSDC
210 220 230 240 250
AFMVDNEAIY DICRRNLDIE RPTYTNLNRL IGQIVSSITA SLRFDGALNV
260 270 280 290 300
DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN
310 320 330 340 350
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG
360 370 380 390 400
FKVGINYQPP TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA
410 420 430 440 450
KRAFVHWYVG EGMEEGEFSE AREDMAALEK DYEEVGMDSV EGEGEEEEGD
EY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A452DJ66 | A0A452DJ66_BOVIN | Tubulin alpha chain | TUBA1D | 449 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC113253 mRNA Translation: AAI13254.1 |
RefSeqi | NP_001039875.1, NM_001046410.1 |
Genome annotation databases
Ensembli | ENSBTAT00000076713; ENSBTAP00000057311; ENSBTAG00000030973 |
GeneIDi | 535605 |
KEGGi | bta:535605 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC113253 mRNA Translation: AAI13254.1 |
RefSeqi | NP_001039875.1, NM_001046410.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JFF | electron microscopy | 3.50 | A | 1-452 | [»] | |
1SA0 | X-ray | 3.58 | A/C | 1-452 | [»] | |
1SA1 | X-ray | 4.20 | A/C | 1-452 | [»] | |
1TVK | electron microscopy | 2.89 | A | 1-440 | [»] | |
1Z2B | X-ray | 4.10 | A/C | 1-451 | [»] | |
2WBE | electron microscopy | 9.40 | A | 1-452 | [»] | |
2XRP | electron microscopy | 8.20 | B/D/F/H | 1-449 | [»] | |
3EDL | electron microscopy | 28.00 | F | 1-452 | [»] | |
3IZ0 | electron microscopy | 8.60 | A | 1-452 | [»] | |
4AQV | electron microscopy | 9.70 | A | 1-452 | [»] | |
4AQW | electron microscopy | 9.50 | A | 1-452 | [»] | |
4ATU | electron microscopy | 8.30 | B/D/F/H | 1-452 | [»] | |
4ATX | electron microscopy | 8.20 | B | 1-452 | [»] | |
4CK5 | electron microscopy | 10.00 | A | 1-452 | [»] | |
4CK6 | electron microscopy | 9.20 | A | 1-452 | [»] | |
4CK7 | electron microscopy | 9.20 | A | 1-452 | [»] | |
5M5I | electron microscopy | 9.30 | A | 1-447 | [»] | |
5M5L | electron microscopy | 9.30 | A | 1-452 | [»] | |
5M5M | electron microscopy | 9.30 | A | 1-452 | [»] | |
5M5N | electron microscopy | 9.30 | A | 1-452 | [»] | |
5M5O | electron microscopy | 9.30 | A | 1-452 | [»] | |
SMRi | Q2HJ86 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000038183 |
Proteomic databases
PaxDbi | Q2HJ86 |
PeptideAtlasi | Q2HJ86 |
PRIDEi | Q2HJ86 |
Genome annotation databases
Ensembli | ENSBTAT00000076713; ENSBTAP00000057311; ENSBTAG00000030973 |
GeneIDi | 535605 |
KEGGi | bta:535605 |
Organism-specific databases
CTDi | 535605 |
Phylogenomic databases
eggNOGi | KOG1376, Eukaryota |
GeneTreei | ENSGT00950000182825 |
HOGENOMi | CLU_015718_0_0_1 |
InParanoidi | Q2HJ86 |
OMAi | HQRECIS |
OrthoDBi | 514396at2759 |
TreeFami | TF300314 |
Miscellaneous databases
EvolutionaryTracei | Q2HJ86 |
Gene expression databases
Bgeei | ENSBTAG00000030973, Expressed in lung and 11 other tissues |
ExpressionAtlasi | Q2HJ86, baseline and differential |
Family and domain databases
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002452, Alpha_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR037103, Tubulin/FtsZ_C_sf IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01162, ALPHATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBA1D_BOVIN | |
Accessioni | Q2HJ86Primary (citable) accession number: Q2HJ86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | March 21, 2006 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families