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Entry version 64 (12 Aug 2020)
Sequence version 1 (21 Mar 2006)
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Protein

Protein transport protein SEC23

Gene

SEC23

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63ZincBy similarity1
Metal bindingi67ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi89ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein SEC23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC23
ORF Names:CHGG_02604
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri306901 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001056 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002954581 – 773Protein transport protein SEC23Add BLAST773

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q2HB00

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
38033.XP_001229120.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2HB00

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1986, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008658_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2HB00

Database of Orthologous Groups

More...
OrthoDBi
270617at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11287, Sec23_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR037364, Sec23
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR037550, Sec23_C
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11141, PTHR11141, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2HB00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYDSMKEQW GEVEDRDGVR LSWNVFPSTR MEASRLVVPI GALYTPLKEK
60 70 80 90 100
PDTPLLQFEP VTCKQPCRSV LNPFCQVDVR ARLWICPFCL SRNPLPPHYK
110 120 130 140 150
DITAQAIPPE LHPSNTTIEY RLSRPAPSPP IFLYVVDTCQ EEDSLAALKE
160 170 180 190 200
SLIMSLSLLP ENALVGLITY GTMAQVHEIG YTECAKSYVF RGSKEYAAKQ
210 220 230 240 250
VQEMLGLIQP AMRPGMPAHQ PGRPMPMGPA SRFLLPVTQA EFQLTKALEQ
260 270 280 290 300
LQQDPWPISS DRRNLRCTGV ALSVAVGLLE TSFQNAGGRI MLFAGGPATE
310 320 330 340 350
GPGMVVGPEL REPIRSHHDI DRDNVKYYKK ALKFYDNLAK RTAHNGHTID
360 370 380 390 400
IFAGCLDQVG LLEMKGLCNS TGGHMILTDS FTSSMFKQSF IRVFEKDGDD
410 420 430 440 450
NLLMGFNAVL EVLTTKELKV TGLIGHAVSL NKKSTSVGET ECGIGNTCSW
460 470 480 490 500
KMCGIDPKAS YGVYFEIAQG GPSQHQQNQK GMIQFLTYYQ HSSGQFHLRV
510 520 530 540 550
TTIARDLSGP AGDPAIAHSF DQEAAAVLMS RIAVFKAEVD DGPDVLRWVD
560 570 580 590 600
RMLIRLCSRF ADYRKDDPSS FRLEKNFTLY PQFMFHLRRS QFLQVFNNSP
610 620 630 640 650
DETAFYRHVL DHEDVSNSLV MIQPTLDSYT FDQEGGQPVL LDSSSIQPTH
660 670 680 690 700
ILLLDTFFHI LIFHGETVAE WRKAGYQDQE GYENFASLLE QPKEDARDLI
710 720 730 740 750
TDRFPLPRFI VCDHGGSQAR FLLSKLNPST THTSGAGAYG GVGAQSAQTI
760 770
FTDDVSLQTF MEHLMKLAVS GTN
Length:773
Mass (Da):86,249
Last modified:March 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCC504E3AA9F2F0B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH408030 Genomic DNA Translation: EAQ90669.1

NCBI Reference Sequences

More...
RefSeqi
XP_001229120.1, XM_001229119.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAQ90669; EAQ90669; CHGG_02604

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4389933

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408030 Genomic DNA Translation: EAQ90669.1
RefSeqiXP_001229120.1, XM_001229119.1

3D structure databases

SMRiQ2HB00
ModBaseiSearch...

Protein-protein interaction databases

STRINGi38033.XP_001229120.1

Proteomic databases

PRIDEiQ2HB00

Genome annotation databases

EnsemblFungiiEAQ90669; EAQ90669; CHGG_02604
GeneIDi4389933

Phylogenomic databases

eggNOGiKOG1986, Eukaryota
HOGENOMiCLU_008658_3_0_1
InParanoidiQ2HB00
OrthoDBi270617at2759

Family and domain databases

CDDicd11287, Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR037364, Sec23
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR037550, Sec23_C
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf
PANTHERiPTHR11141, PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC23_CHAGB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2HB00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 21, 2006
Last modified: August 12, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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