UniProtKB - Q2H7U1 (KATG_CHAGB)
Protein
Catalase-peroxidase
Gene
katG
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Functioni
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation
Catalytic activityi
Cofactori
heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 87 | Transition state stabilizerUniRule annotation | 1 | |
Active sitei | 91 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 279 | Iron (heme axial ligand)UniRule annotation | 1 |
GO - Molecular functioni
- catalase activity Source: UniProtKB-UniRule
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- hydrogen peroxide catabolic process Source: UniProtKB-KW
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Biological process | Hydrogen peroxide |
Ligand | Heme, Iron, Metal-binding |
Protein family/group databases
PeroxiBasei | 3408 CgCP01 |
Names & Taxonomyi
Protein namesi | Recommended name: Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)Short name: CPUniRule annotation Alternative name(s): Peroxidase/catalaseUniRule annotation |
Gene namesi | Name:katGUniRule annotation ORF Names:CHGG_05274 |
Organismi | Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) |
Taxonomic identifieri | 306901 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium › |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000354105 | 1 – 749 | Catalase-peroxidaseAdd BLAST | 749 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 90 ↔ 238 | Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-264)UniRule annotation | ||
Cross-linki | 238 ↔ 264 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-90)UniRule annotation |
Post-translational modificationi
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation
Proteomic databases
PRIDEi | Q2H7U1 |
Interactioni
Subunit structurei
Homodimer or homotetramer.
UniRule annotationProtein-protein interaction databases
STRINGi | 38033.XP_001221369.1 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG410IEWS Eukaryota COG0376 LUCA |
InParanoidi | Q2H7U1 |
OrthoDBi | 352289at2759 |
Family and domain databases
HAMAPi | MF_01961 Catal_peroxid, 1 hit |
InterProi | View protein in InterPro IPR000763 Catalase_peroxidase IPR002016 Haem_peroxidase IPR010255 Haem_peroxidase_sf IPR019794 Peroxidases_AS IPR019793 Peroxidases_heam-ligand_BS |
PANTHERi | PTHR30555 PTHR30555, 1 hit |
Pfami | View protein in Pfam PF00141 peroxidase, 2 hits |
PRINTSi | PR00460 BPEROXIDASE PR00458 PEROXIDASE |
SUPFAMi | SSF48113 SSF48113, 2 hits |
TIGRFAMsi | TIGR00198 cat_per_HPI, 1 hit |
PROSITEi | View protein in PROSITE PS00435 PEROXIDASE_1, 1 hit PS00436 PEROXIDASE_2, 1 hit PS50873 PEROXIDASE_4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2H7U1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGECPVNHAN VAGGGTRNND WWPNQLRLNI LRQHQPASSP YSKEFDYAAA
60 70 80 90 100
FKSLDYEALK KDITAVMTDS QDWWPADFGH YGGLFIRMAW HSAGTYRVFD
110 120 130 140 150
GRGGGSQGQQ RFAPLNSWPD NVSLDKARRL LWPVKQKYGD KISWADLLLL
160 170 180 190 200
TGNVALESMG FKTFGFAGGR PDTWEADESA YWGGEKTWLG NDVRYGQGNE
210 220 230 240 250
GVAGQGVVDG DESKKGHRDI HSRDLESPLA AAHMGLIYVN PEGPDGIPDP
260 270 280 290 300
VAAGRDIRTT FGRMAMNDEE TVALIAGGHT FGKTHGAAPA VNVSKEPEAA
310 320 330 340 350
PLEQQGLGWS NKHGTGKGPD TITSGLEVIW TKEPTKWTHN FFEYLFKFEW
360 370 380 390 400
ELTKSPAGAN QWVAKNTEPI IPDAFDPNKK HLPRMLTTDL ALRFDPEYEK
410 420 430 440 450
ISRRFLENPD QFADAFARAW FKLLHRDLGP RSRWLGPEIP SEVLIWEDPV
460 470 480 490 500
PAVNHPLVDE QDVTTLKRAI LATGVAPAKL ISTAWASAST FRGGDKRGGA
510 520 530 540 550
NGARIRLAPQ KDWKVNNPPQ LAEVLKALEG VQAQFNGASQ SKKVSLADLI
560 570 580 590 600
VLGGVAALEQ AAGVSVPFTP GRTDASQEQT EVESFAHLEP HVDGFRSYGR
610 620 630 640 650
GTSRVSTEQF LVDRAHLLTL TPPELAVLVG GLRVLGANYD GSSNGVFTTR
660 670 680 690 700
PGKLTNDYFV NLLDMATAWK SVDGEVFEGN DRKTGEKKWT GTRADLVFGA
710 720 730 740
HAELRAISEV YGSSSGQDKF VKDFVAAWSK VMNLDRYDLA QPGSSGPKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH408031 Genomic DNA Translation: EAQ88655.1 |
RefSeqi | XP_001221369.1, XM_001221368.1 |
Genome annotation databases
EnsemblFungii | EAQ88655; EAQ88655; CHGG_05274 |
GeneIDi | 4391274 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH408031 Genomic DNA Translation: EAQ88655.1 |
RefSeqi | XP_001221369.1, XM_001221368.1 |
3D structure databases
SMRi | Q2H7U1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 38033.XP_001221369.1 |
Protein family/group databases
PeroxiBasei | 3408 CgCP01 |
Proteomic databases
PRIDEi | Q2H7U1 |
Genome annotation databases
EnsemblFungii | EAQ88655; EAQ88655; CHGG_05274 |
GeneIDi | 4391274 |
Phylogenomic databases
eggNOGi | ENOG410IEWS Eukaryota COG0376 LUCA |
InParanoidi | Q2H7U1 |
OrthoDBi | 352289at2759 |
Family and domain databases
HAMAPi | MF_01961 Catal_peroxid, 1 hit |
InterProi | View protein in InterPro IPR000763 Catalase_peroxidase IPR002016 Haem_peroxidase IPR010255 Haem_peroxidase_sf IPR019794 Peroxidases_AS IPR019793 Peroxidases_heam-ligand_BS |
PANTHERi | PTHR30555 PTHR30555, 1 hit |
Pfami | View protein in Pfam PF00141 peroxidase, 2 hits |
PRINTSi | PR00460 BPEROXIDASE PR00458 PEROXIDASE |
SUPFAMi | SSF48113 SSF48113, 2 hits |
TIGRFAMsi | TIGR00198 cat_per_HPI, 1 hit |
PROSITEi | View protein in PROSITE PS00435 PEROXIDASE_1, 1 hit PS00436 PEROXIDASE_2, 1 hit PS50873 PEROXIDASE_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KATG_CHAGB | |
Accessioni | Q2H7U1Primary (citable) accession number: Q2H7U1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2008 |
Last sequence update: | March 21, 2006 | |
Last modified: | September 18, 2019 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families