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Protein

Mitochondrial glycine transporter

Gene

CHGG_05907

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:CHGG_05907
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 41Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei68 – 94Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei131 – 156Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei184 – 207Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei239 – 265Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei294 – 312Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789331 – 333Mitochondrial glycine transporterAdd BLAST333

Proteomic databases

PRIDEiQ2H608

Interactioni

Protein-protein interaction databases

STRINGi306901.XP_001222002.1

Structurei

3D structure databases

ProteinModelPortaliQ2H608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 93Solcar 1UniRule annotationAdd BLAST84
Repeati125 – 209Solcar 2UniRule annotationAdd BLAST85
Repeati235 – 319Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
InParanoidiQ2H608
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q2H608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGSRTALS KSTFHFAAGL GSGVLSAVLL QPIDLLKTRV QQSGAHSLSA
60 70 80 90 100
AIADIRAAPR LLPALWRGAV PSALRTGFGS AIYFTSLNAI RQSAARISPL
110 120 130 140 150
PSSSSSTTTS SSTTTSSSSS SLPKLSNTSN LLAGAAARSL AGLILMPLTV
160 170 180 190 200
LKVRYESTLY NYTSLASAAR DIAAHEGARG FFAGYGATAV RDAPYAGLYV
210 220 230 240 250
LFYEQGKKRL SQLFPTTTTT TTTNSTQNGP MGLQHAASIN FASGVLAGVI
260 270 280 290 300
CSVVSNPFDA VKTRIQLQPG RYRNMVSGAR RMVGEEGVRA LWDGLALRMS
310 320 330
RKAVSSALAW TVYEELIRRA EAGWRAGAAR ERL
Length:333
Mass (Da):35,113
Last modified:March 21, 2006 - v1
Checksum:i561A7B31C654223E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408031 Genomic DNA Translation: EAQ89288.1
RefSeqiXP_001222002.1, XM_001222001.1

Genome annotation databases

EnsemblFungiiEAQ89288; EAQ89288; CHGG_05907
GeneIDi4391050

Similar proteinsi

Entry informationi

Entry nameiS2538_CHAGB
AccessioniPrimary (citable) accession number: Q2H608
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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