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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185By similarity1
Active sitei385By similarity1
Active sitei447By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

ESTHERichagb-q2gyb7 Carboxypeptidase_S10
MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CHGG_07037
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 519LumenalSequence analysisAdd BLAST489
Transmembranei520 – 540HelicalSequence analysisAdd BLAST21
Topological domaini541 – 643CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000041191231 – 643Pheromone-processing carboxypeptidase KEX1Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi306901.XP_001224693.1

Structurei

3D structure databases

ProteinModelPortaliQ2GYB7
SMRiQ2GYB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi529 – 534Poly-Ala6

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiQ2GYB7
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2GYB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPSWPSTGC WRHLPVVLAA LTLPWTATLA AAEKSAGDYF VHSLPGAPEG
60 70 80 90 100
PLVKMHAGHI EVTPETNGNL FFWHFQNKHI ANKQRTVIWL NGGPGCSSED
110 120 130 140 150
GALMEIGPYR LKDDKTLMYN DGAWNEFANV LFVDNPVGTG FSYVDTNAYV
160 170 180 190 200
RELDEMAEQF VIFMEKWYKL FPEYEHDDLY FAGESYAGQY IPYIAKHVLA
210 220 230 240 250
RNKEAGTKQW NLKGLLIGNG WISPPEQYEA YLQFAFEKGL VKKGSDIASK
260 270 280 290 300
LEVQLRICQK DLAVGESAVD HPECEKILQE ILKLTATRGK DNKLECYNMY
310 320 330 340 350
DVRLKDVYPS CGMNWPSDLA NVQPYLRRKD VVQALHVNPN KVTGWVECDG
360 370 380 390 400
RVGQNFNPVK SKPSIDLLPD ILSEVPVMLF SGAEDLICNH LGTEALISRM
410 420 430 440 450
AWNGGRGFEL SPGTWAPRRD WTFEGEDAGF WQEARNLTYV VFYNASHMVP
460 470 480 490 500
YDHPRRTRDM LDRFMGVDIS SIGGDPTDSR LDGEKGPETT VGGTAGNGNA
510 520 530 540 550
DQEAEKAKLS AAKWEAYRRS GEIVLVIVAV AAAAWGYFVW RERRKRRGYQ
560 570 580 590 600
GLASAENGAA GGVMGGNSGF RNTHGGRPRS DVEAGDFDET QLDSLHVRSP
610 620 630 640
VEGQEDARYS LGAVSDDDDE EEEGSAAGAK GKEKETGKAA ESS
Length:643
Mass (Da):71,275
Last modified:March 21, 2006 - v1
Checksum:i0BFAD91EF80932D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408033 Genomic DNA Translation: EAQ85784.1
RefSeqiXP_001224693.1, XM_001224692.1

Genome annotation databases

EnsemblFungiiEAQ85784; EAQ85784; CHGG_07037
GeneIDi4393231

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408033 Genomic DNA Translation: EAQ85784.1
RefSeqiXP_001224693.1, XM_001224692.1

3D structure databases

ProteinModelPortaliQ2GYB7
SMRiQ2GYB7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306901.XP_001224693.1

Protein family/group databases

ESTHERichagb-q2gyb7 Carboxypeptidase_S10
MEROPSiS10.007

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAQ85784; EAQ85784; CHGG_07037
GeneIDi4393231

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiQ2GYB7
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_CHAGB
AccessioniPrimary (citable) accession number: Q2GYB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 21, 2006
Last modified: May 10, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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