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Entry version 68 (31 Jul 2019)
Sequence version 1 (21 Mar 2006)
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Protein
Submitted name:

Type IV secretion system protein, VirB6 family

Gene

NSE_0859

Organism
Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
NSEN222891:G1G5M-706-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Type IV secretion system protein, VirB6 familyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:NSE_0859Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri222891 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001942 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei334 – 353HelicalSequence analysisAdd BLAST20
Transmembranei441 – 466HelicalSequence analysisAdd BLAST26
Transmembranei473 – 495HelicalSequence analysisAdd BLAST23
Transmembranei507 – 528HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
222891.NSE_0859

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni876 – 916DisorderedSequence analysisAdd BLAST41
Regioni934 – 1080DisorderedSequence analysisAdd BLAST147
Regioni1104 – 1149DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi901 – 916PolarSequence analysisAdd BLAST16
Compositional biasi962 – 990PolarSequence analysisAdd BLAST29
Compositional biasi999 – 1025PolarSequence analysisAdd BLAST27

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108QTG Bacteria
COG3704 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000127177

KEGG Orthology (KO)

More...
KOi
K03201

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITHMWES

Database of Orthologous Groups

More...
OrthoDBi
62584at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007688 Conjugal_tfr_TrbL/VirB6

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04610 TrbL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2GCS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLPNRIME FVPRVRQVMM KKIRVAKVSN RIARYCPSGL KRVLVLMLGL
60 70 80 90 100
FLLSGCEKCE NVCPRCIAAD DFGIPKSSAA ALIEYDSPLL KSDAALLGLE
110 120 130 140 150
DNTSGRQLMR WEDSGYVTSG EPITLNVEGR WLFMPARSVL RFSRDEIQKV
160 170 180 190 200
FRCGDIDYEA LKEADEEFKK NFPNQSCTYL ATQMTDITTG CLINGAKIDP
210 220 230 240 250
KFSQSGCILE KGYGLYLLFY RPGDPNPNTT FSSIATPASP AMHIGYTGDS
260 270 280 290 300
ITIESVFTSD CTRLNLEPGW KIYYKLMDVF YQNNVGGYSL EFRTGVIDPK
310 320 330 340 350
NTAKFFESVR SMLQDLLTGQ NEAIYKAITS NNDYVSLVKA LIVLMIVLTG
360 370 380 390 400
LRFLMGISES PPSELLIKVL KMAIILQLIS PSSWDFFYNN LFRLFIDGLN
410 420 430 440 450
EVIAVVNSHT GAGYQLDQPF AFLDDTVNIL FKMLVSTKVK AIILAYPLGV
460 470 480 490 500
FWWLILFFIL VIYVVLVAYA FVVYLTALIG LSVLIVLMPV LFLGMLFGQL
510 520 530 540 550
KHTFDNWFTQ ALSFCFQAIM IFTVVSLFSA MIKDQFYRNT GYTICCNKFW
560 570 580 590 600
VFPFNISVYA WTPGQKFMPL TITHMWESKR VEFTGGAKVI DIPPYYKERG
610 620 630 640 650
CRFVDYPFYD PQISNANCGI AGFAGKGADW ERIEKIRESD SGLLDMAEVF
660 670 680 690 700
VLLLLSVIMF HMRDLCQSIG ASLVGASPFQ AVIGGAYAAQ DGIGGLYRAG
710 720 730 740 750
KMVIGALADK LPVLSGVRNS ADDIASLRSR VGESIAAKLN ETNLGEATMK
760 770 780 790 800
VLSTVGDVSS GIVKGTGYLL GVNSELSDHY YEKKAFRQIN YTQALMGYHL
810 820 830 840 850
VSIVGTRDLS DSPGIKMLFG GLKHMSDKYF VGAKEESLFG GLRKLYVCER
860 870 880 890 900
EKIHDYYLGI QREKLPECMD DIKRNEKPTA DFSSSTEDGL SIDKKSDANG
910 920 930 940 950
NLSHHPNSLP PSYSEIEFEN TTPDISLELP EFVSTGETSP GLTPQTAVEE
960 970 980 990 1000
AHRDSVGEES SAFDVSRGSS EDMSAGETSP ELTPQTAVEE AHRNSVGEES
1010 1020 1030 1040 1050
SAFDVSRGSS EDMSAGATSP ELTPQTAVEE AHRDSVGEES SAFDVSRGVT
1060 1070 1080 1090 1100
KNTATDEAGL ELASHGRTEQ DTAEASNAED TASAFSNVTQ DGGGIFGSLI
1110 1120 1130 1140
EGAVSKQGTS KDPSHSVTSA EEQAKKPTKK PKGRKLPGQF VETEENSEE
Length:1,149
Mass (Da):126,628
Last modified:March 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BC26BC001D89A3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000237 Genomic DNA Translation: ABD46403.1

NCBI Reference Sequences

More...
RefSeqi
WP_011452232.1, NC_007798.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABD46403; ABD46403; NSE_0859

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nse:NSE_0859

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA Translation: ABD46403.1
RefSeqiWP_011452232.1, NC_007798.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi222891.NSE_0859

Genome annotation databases

EnsemblBacteriaiABD46403; ABD46403; NSE_0859
KEGGinse:NSE_0859

Phylogenomic databases

eggNOGiENOG4108QTG Bacteria
COG3704 LUCA
HOGENOMiHOG000127177
KOiK03201
OMAiITHMWES
OrthoDBi62584at2

Enzyme and pathway databases

BioCyciNSEN222891:G1G5M-706-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR007688 Conjugal_tfr_TrbL/VirB6
PfamiView protein in Pfam
PF04610 TrbL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2GCS0_NEOSM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2GCS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: July 31, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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