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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Multifunctional fusion protein (hisF)
  3. Multifunctional fusion protein (hisF)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Multifunctional fusion protein (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-686-MONOMER
UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminaseUniRule annotation
Gene namesi
Name:hisCUniRule annotation
Ordered Locus Names:SAOUHSC_00733
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000635051 – 352Histidinol-phosphate aminotransferaseAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00733

Structurei

3D structure databases

ProteinModelPortaliQ2G087
SMRiQ2G087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiHGFLVYR

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2G087-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEQLNQLSA YQPGLSPRAL KEKYGIEGDL YKLASNENLY GPSPKVKEAI
60 70 80 90 100
SAHLDELYYY PETGSPTLKA AISKHLNVDQ SRILFGAGLD EVILMISRAV
110 120 130 140 150
LTPGDTIVTS EATFGQYYHN AIVESANVIQ VPLKDGGFDL EGILKEVNED
160 170 180 190 200
TSLVWLCNPN NPTGTYFNHE SLDSFLSQVP PHVPVIIDEA YFEFVTAEDY
210 220 230 240 250
PDTLALQQKY DNAFLLRTFS KAYGLAGLRV GYVVASEHAI EKWNIIRPPF
260 270 280 290 300
NVTRISEYAA VAALEDQQYL KEVTHKNSVE RERFYQLPQS EYFLPSQTNF
310 320 330 340 350
IFVKTKRVNE LYEALLNVGC ITRPFPTGVR ITIGFKEQND KMLEVLSNFK

YE
Length:352
Mass (Da):39,788
Last modified:March 21, 2006 - v1
Checksum:iD6AA6041524D4700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD29866.1
RefSeqiWP_000663030.1, NC_007795.1
YP_499293.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD29866; ABD29866; SAOUHSC_00733
GeneIDi3920978
KEGGisao:SAOUHSC_00733
PATRICifig|93061.5.peg.662

Similar proteinsi

Entry informationi

Entry nameiHIS8_STAA8
AccessioniPrimary (citable) accession number: Q2G087
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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