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Protein

Argininosuccinate synthase

Gene

argG

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85CitrullineUniRule annotation1
Binding sitei115ATP; via amide nitrogenUniRule annotation1
Binding sitei117AspartateUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei121CitrullineUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei125CitrullineUniRule annotation1
Binding sitei173CitrullineUniRule annotation1
Binding sitei258CitrullineUniRule annotation1
Binding sitei270CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 16ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-842-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:SAOUHSC_00899
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002639761 – 401Argininosuccinate synthaseAdd BLAST401

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00899

Structurei

3D structure databases

ProteinModelPortaliQ2FZU1
SMRiQ2FZU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FZU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKIVLAYS GGLDTSVAVQ WLIDKGYDVV ACCLDVGEGK DLDIVYKKAL
60 70 80 90 100
DMGAVECHII DATKEFSDEY VSYAIKGNLM YENAYPLVSA LSRPLIAKKL
110 120 130 140 150
VEIAEKTNSV GIAHGCTGKG NDQVRFEVAI KALNPSLKAF APVREWAWSR
160 170 180 190 200
EEEIDYAIKH NIPVSINHDS PYSIDQNLWG RANECGILED PYAAPPEDAF
210 220 230 240 250
DLTNALEETP DTADEIILTF DKGIPVQIDG KTYELDDLIL TLNALAGKHG
260 270 280 290 300
IGRIDHVENR LVGIKSREIY EAPAAEVILK AHKALETITL TKDVAHFKPI
310 320 330 340 350
IEKQFAEQLY NGLWFSPLTD SLKLFIDSTQ QYVSGDVRIK LFKGNAIVNG
360 370 380 390 400
RKSPYTLYDE KLATYTKEDA FNQDAAVGFI DIYGLPTQVN AMLHGGYSNE

Q
Length:401
Mass (Da):44,455
Last modified:March 21, 2006 - v1
Checksum:iBAA35E9F6C6FD5A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD30024.1
RefSeqiWP_000660045.1, NC_007795.1
YP_499452.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD30024; ABD30024; SAOUHSC_00899
GeneIDi3921745
KEGGisao:SAOUHSC_00899
PATRICifig|93061.5.peg.820

Similar proteinsi

Entry informationi

Entry nameiASSY_STAA8
AccessioniPrimary (citable) accession number: Q2FZU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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