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Protein

Ribonuclease HIII

Gene

rnhC

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Divalent metal cationUniRule annotation1
Metal bindingi102Divalent metal cationUniRule annotation1
Metal bindingi206Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1028-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIIUniRule annotation
Gene namesi
Name:rnhCUniRule annotation
Ordered Locus Names:SAOUHSC_01095
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000312371 – 312Ribonuclease HIIIAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01095

Structurei

3D structure databases

ProteinModelPortaliQ2FZD7
SMRiQ2FZD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family. RnhC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107FSS Bacteria
COG1039 LUCA
HOGENOMiHOG000292531
KOiK03471
OMAiTGDYFGP

Family and domain databases

CDDicd14796 RNAse_HIII_N, 1 hit
Gene3Di3.30.310.10, 1 hit
3.30.420.10, 1 hit
HAMAPiMF_00053 RNase_HIII, 1 hit
InterProiView protein in InterPro
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR004641 RNase_HIII
IPR024568 RNase_HIII_N
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PfamiView protein in Pfam
PF11858 DUF3378, 1 hit
PF01351 RNase_HII, 1 hit
PIRSFiPIRSF037748 RnhC, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00716 rnhC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FZD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANIVFKLSD KDITTLMSRI SFDTENLPQG MKARAKYQNT TVNIYQSGKV
60 70 80 90 100
MFQGNHAEAV SEELLPQHSQ LNTNKTKKKN MANSFLEQTL MYDQFNCIGS
110 120 130 140 150
DEAGSGDYFG PLTVCAAFVT KEHVPILKTL GVDDSKKLTD TKIVELAEQL
160 170 180 190 200
VTFIPHSLLT LHNEKYNIQQ AKGWTQVKMK AALHNEAIKN VLEKIDSSQL
210 220 230 240 250
DYIVIDQFAK REVYSHYALS DIPLPKKTKF ETKGESKSLA IAVASIISRY
260 270 280 290 300
AFVTYMDQIS KNINMTIPKG AGAKVDVIAA KIIKKYGLSR LDTISKKHFK
310
NREKAQKILK PL
Length:312
Mass (Da):35,055
Last modified:March 21, 2006 - v1
Checksum:iFFB2A5B878C599C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD30209.1
RefSeqiWP_001284258.1, NC_007795.1
YP_499639.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD30209; ABD30209; SAOUHSC_01095
GeneIDi3920737
KEGGisao:SAOUHSC_01095
PATRICifig|93061.5.peg.1003

Similar proteinsi

Entry informationi

Entry nameiRNH3_STAA8
AccessioniPrimary (citable) accession number: Q2FZD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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