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Protein

Ribonuclease 3

Gene

rnc

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59MagnesiumUniRule annotation1
Active sitei63UniRule annotation1
Metal bindingi132MagnesiumUniRule annotation1
Active sitei135UniRule annotation1
Metal bindingi135MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1127-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:SAOUHSC_01203
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000758291 – 243Ribonuclease 3Add BLAST243

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01203

Structurei

3D structure databases

ProteinModelPortaliQ2FZ50
SMRiQ2FZ50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 146RNase IIIUniRule annotationAdd BLAST137
Domaini172 – 241DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FZ50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKQKKSEIV NRFRKRFDTK MTELGFTYQN IDLYQQAFSH SSFINDFNMN
60 70 80 90 100
RLDHNERLEF LGDAVLELTV SRYLFDKHPN LPEGNLTKMR ATIVCEPSLV
110 120 130 140 150
IFANKIGLNE MILLGKGEEK TGGRTRPSLI SDAFEAFIGA LYLDQGLDIV
160 170 180 190 200
WKFAEKVIFP HVEQNELLGV VDFKTQFQEY VHQQNKGDVT YNLIKEEGPA
210 220 230 240
HHRLFTSEVI LQGEAIAEGK GKTKKESEQR AAESAYKQLK QIK
Length:243
Mass (Da):27,922
Last modified:March 21, 2006 - v1
Checksum:i875034DEBC3455A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD30308.1
RefSeqiWP_000043237.1, NC_007795.1
YP_499740.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD30308; ABD30308; SAOUHSC_01203
GeneIDi3919469
KEGGisao:SAOUHSC_01203
PATRICifig|93061.5.peg.1103

Similar proteinsi

Entry informationi

Entry nameiRNC_STAA8
AccessioniPrimary (citable) accession number: Q2FZ50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 21, 2006
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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