Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Octanoyltransferase LipM

Gene

lipM

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.UniRule annotation

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. The reaction proceeds via an octanoyl-thioester enzyme intermediate.UniRule annotation

Catalytic activityi

Octanoyl-[acyl-carrier-protein] + protein = protein N6-(octanoyl)lysine + [acyl-carrier-protein].UniRule annotation

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].UniRule annotation This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Acyl-thioester intermediateUniRule annotation1
Sitei164Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1516-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyltransferase LipMUniRule annotation (EC:2.3.1.181UniRule annotation)
Alternative name(s):
Octanoyl-[acyl-carrier-protein]:[GcvH] N-octanoyltransferaseUniRule annotation
Gene namesi
Name:lipMUniRule annotation
Ordered Locus Names:SAOUHSC_01629
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004108631 – 276Octanoyltransferase LipMAdd BLAST276

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01629

Structurei

3D structure databases

ProteinModelPortaliQ2FY37
SMRiQ2FY37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 247BPL/LPL catalyticPROSITE-ProRule annotationAdd BLAST216

Sequence similaritiesi

Belongs to the octanoyltransferase LipM family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107S5Z Bacteria
COG0095 LUCA
HOGENOMiHOG000245032
KOiK03800
OMAiAMFMEAG

Family and domain databases

HAMAPiMF_02118 LipM, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024898 LipM
PANTHERiPTHR43679:SF3 PTHR43679:SF3, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FY37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTETWNFINT GSKDPYYNMA MDEALLNFVS RGEIDPVIRF YTWNPATLSI
60 70 80 90 100
GYFQRLQKEI DIDKVKEKGF GLVRRQTGGR GVLHDKELTY SVIVPESHPN
110 120 130 140 150
MPSTVTEAYR VISQGLLEGF KNLGFDTYFA VPKTPEERQK LKQPRSSVCF
160 170 180 190 200
DAPSWYELVV EGRKIAGSAQ TRQKGVILQH GSILQDIDID ELFDMFIYKN
210 220 230 240 250
ERLKLKMKEA FVEKAVAIND ISDEHITISQ MEEAFEKGFK KGLNIELKPL
260 270
ELTEAQLAEV EELTEKYRSD EWMFRK
Length:276
Mass (Da):31,881
Last modified:March 21, 2006 - v1
Checksum:i57FFFD25C65742BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD30707.1
RefSeqiWP_000141109.1, NZ_LS483365.1
YP_500143.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD30707; ABD30707; SAOUHSC_01629
GeneIDi3919967
KEGGisao:SAOUHSC_01629
PATRICifig|93061.5.peg.1483

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD30707.1
RefSeqiWP_000141109.1, NZ_LS483365.1
YP_500143.1, NC_007795.1

3D structure databases

ProteinModelPortaliQ2FY37
SMRiQ2FY37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01629

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD30707; ABD30707; SAOUHSC_01629
GeneIDi3919967
KEGGisao:SAOUHSC_01629
PATRICifig|93061.5.peg.1483

Phylogenomic databases

eggNOGiENOG4107S5Z Bacteria
COG0095 LUCA
HOGENOMiHOG000245032
KOiK03800
OMAiAMFMEAG

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1516-MONOMER

Miscellaneous databases

PROiPR:Q2FY37

Family and domain databases

HAMAPiMF_02118 LipM, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024898 LipM
PANTHERiPTHR43679:SF3 PTHR43679:SF3, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIPM_STAA8
AccessioniPrimary (citable) accession number: Q2FY37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: March 21, 2006
Last modified: October 10, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again