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Protein

50S ribosomal protein L5

Gene

rplE

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.UniRule annotation

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-UniRule
  • structural constituent of ribosome Source: GO_Central
  • tRNA binding Source: UniProtKB-UniRule

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-2363-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L5UniRule annotation
Gene namesi
Name:rplEUniRule annotation
Ordered Locus Names:SAOUHSC_02500
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000528371 – 17950S ribosomal protein L5Add BLAST179

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02500

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ2FW18
SMRiQ2FW18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL5 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CW6 Bacteria
COG0094 LUCA
HOGENOMiHOG000231311
KOiK02931
OMAiEQVMFHE

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
HAMAPiMF_01333_B Ribosomal_L5_B, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR020930 Ribosomal_L5_bac-type
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FW18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRLKEKFNT EVTENLMKKF NYSSVMEVPK IDKIVVNMGV GDAVQNSKVL
60 70 80 90 100
DNAVEELELI TGQKPLVTKA KKSIATFRLR EGMPIGAKVT LRGERMYEFL
110 120 130 140 150
DKLISVSLPR VRDFQGVSKK AFDGRGNYTL GVKEQLIFPE IDYDKVSKVR
160 170
GMDIVIVTTA NTDEEARELL ANFGMPFRK
Length:179
Mass (Da):20,267
Last modified:March 21, 2006 - v1
Checksum:i3A0070FDF84DF93B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD31518.1
RefSeqiWP_001080824.1, NZ_LS483365.1
YP_500967.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD31518; ABD31518; SAOUHSC_02500
GeneIDi3920876
KEGGisao:SAOUHSC_02500
PATRICifig|93061.5.peg.2255

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD31518.1
RefSeqiWP_001080824.1, NZ_LS483365.1
YP_500967.1, NC_007795.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WCEX-ray3.53D1-179[»]
4WF9X-ray3.43D1-179[»]
4WFAX-ray3.39D1-179[»]
4WFBX-ray3.43D1-179[»]
5HKVX-ray3.66D1-179[»]
5HL7X-ray3.55D1-179[»]
5LI0electron microscopy3.80G5-170[»]
5ND8electron microscopy3.70G1-179[»]
5ND9electron microscopy3.70G1-179[»]
5NRGX-ray3.44D1-179[»]
5TCUelectron microscopy3.90LK2-167[»]
ProteinModelPortaliQ2FW18
SMRiQ2FW18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02500

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31518; ABD31518; SAOUHSC_02500
GeneIDi3920876
KEGGisao:SAOUHSC_02500
PATRICifig|93061.5.peg.2255

Phylogenomic databases

eggNOGiENOG4105CW6 Bacteria
COG0094 LUCA
HOGENOMiHOG000231311
KOiK02931
OMAiEQVMFHE

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-2363-MONOMER

Miscellaneous databases

PROiPR:Q2FW18

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
HAMAPiMF_01333_B Ribosomal_L5_B, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR020930 Ribosomal_L5_bac-type
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL5_STAA8
AccessioniPrimary (citable) accession number: Q2FW18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: November 7, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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