UniProtKB - Q2FUY1 (ARCR_STAA8)
Protein
HTH-type transcriptional regulator ArcR
Gene
arcR
Organism
Staphylococcus aureus (strain NCTC 8325 / PS 47)
Status
Functioni
Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'-TGTGAN6TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 129 | cNMPAdd BLAST | 90 | |
DNA bindingi | 188 – 207 | H-T-H motifBy similarityAdd BLAST | 20 |
GO - Molecular functioni
- cAMP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: CACAO
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | cAMP, cAMP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator ArcR |
Gene namesi | Name:arcR Ordered Locus Names:SAOUHSC_02964 |
Organismi | Staphylococcus aureus (strain NCTC 8325 / PS 47) |
Taxonomic identifieri | 93061 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349414 | 1 – 234 | HTH-type transcriptional regulator ArcRAdd BLAST | 234 |
Expressioni
Inductioni
Induced by arginine and anaerobic growth during the stationary phase. Repressed under aerobic conditions independently of the growth phase and by glucose catabolic repression.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 228 | HTH crp-typeAdd BLAST | 74 |
Phylogenomic databases
eggNOGi | COG0664, Bacteria |
HOGENOMi | CLU_1160528_0_0_9 |
OMAi | EYLCKNH |
Family and domain databases
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR012318, HTH_CRP IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF13545, HTH_Crp_2, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF51206, SSF51206, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2FUY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY
60 70 80 90 100
FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV
110 120 130 140 150
NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM
160 170 180 190 200
ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE
210 220 230
TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ566750 Genomic DNA Translation: CAD98185.1 CP000253 Genomic DNA Translation: ABD31954.1 |
RefSeqi | WP_000138214.1, NZ_LS483365.1 YP_501415.1, NC_007795.1 |
Genome annotation databases
EnsemblBacteriai | ABD31954; ABD31954; SAOUHSC_02964 |
GeneIDi | 3921666 |
KEGGi | sao:SAOUHSC_02964 |
PATRICi | fig|93061.5.peg.2674 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ566750 Genomic DNA Translation: CAD98185.1 CP000253 Genomic DNA Translation: ABD31954.1 |
RefSeqi | WP_000138214.1, NZ_LS483365.1 YP_501415.1, NC_007795.1 |
3D structure databases
SMRi | Q2FUY1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 1280.SAXN108_2902 |
Genome annotation databases
EnsemblBacteriai | ABD31954; ABD31954; SAOUHSC_02964 |
GeneIDi | 3921666 |
KEGGi | sao:SAOUHSC_02964 |
PATRICi | fig|93061.5.peg.2674 |
Phylogenomic databases
eggNOGi | COG0664, Bacteria |
HOGENOMi | CLU_1160528_0_0_9 |
OMAi | EYLCKNH |
Miscellaneous databases
PROi | PR:Q2FUY1 |
Family and domain databases
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR012318, HTH_CRP IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF13545, HTH_Crp_2, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF51206, SSF51206, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARCR_STAA8 | |
Accessioni | Q2FUY1Primary (citable) accession number: Q2FUY1 Secondary accession number(s): Q7X2S1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | March 21, 2006 | |
Last modified: | February 10, 2021 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |