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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'-TGTGAN6TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 129cNMPAdd BLAST90
DNA bindingi188 – 207H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: CACAO
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-2788-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:SAOUHSC_02964
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003494141 – 234HTH-type transcriptional regulator ArcRAdd BLAST234

Expressioni

Inductioni

Induced by arginine and anaerobic growth during the stationary phase. Repressed under aerobic conditions independently of the growth phase and by glucose catabolic repression.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02964

Structurei

3D structure databases

ProteinModelPortaliQ2FUY1
SMRiQ2FUY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 228HTH crp-typeAdd BLAST74

Phylogenomic databases

eggNOGiENOG4105IJS Bacteria
COG0664 LUCA
HOGENOMiHOG000022896
KOiK21828
OMAiEYLCKNH

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR012318 HTH_CRP
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF13545 HTH_Crp_2, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51206 SSF51206, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FUY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY
60 70 80 90 100
FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV
110 120 130 140 150
NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM
160 170 180 190 200
ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE
210 220 230
TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV
Length:234
Mass (Da):27,428
Last modified:March 21, 2006 - v1
Checksum:iA26B08D8A1EA396E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566750 Genomic DNA Translation: CAD98185.1
CP000253 Genomic DNA Translation: ABD31954.1
RefSeqiWP_000138214.1, NZ_LS483365.1
YP_501415.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD31954; ABD31954; SAOUHSC_02964
GeneIDi3921666
KEGGisao:SAOUHSC_02964
PATRICifig|93061.5.peg.2674

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566750 Genomic DNA Translation: CAD98185.1
CP000253 Genomic DNA Translation: ABD31954.1
RefSeqiWP_000138214.1, NZ_LS483365.1
YP_501415.1, NC_007795.1

3D structure databases

ProteinModelPortaliQ2FUY1
SMRiQ2FUY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02964

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31954; ABD31954; SAOUHSC_02964
GeneIDi3921666
KEGGisao:SAOUHSC_02964
PATRICifig|93061.5.peg.2674

Phylogenomic databases

eggNOGiENOG4105IJS Bacteria
COG0664 LUCA
HOGENOMiHOG000022896
KOiK21828
OMAiEYLCKNH

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-2788-MONOMER

Miscellaneous databases

PROiPR:Q2FUY1

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR012318 HTH_CRP
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF13545 HTH_Crp_2, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51206 SSF51206, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARCR_STAA8
AccessioniPrimary (citable) accession number: Q2FUY1
Secondary accession number(s): Q7X2S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 21, 2006
Last modified: October 10, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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