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Protein

CRISPR-associated endoribonuclease Cas2 1

Gene

cas2-1

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11Magnesium; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processAntiviral defense
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMHUN323259:G1G5Z-782-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
CRISPR-associated endoribonuclease Cas2 1UniRule annotation (EC:3.1.-.-UniRule annotation)
Gene namesi
Name:cas2-1UniRule annotation
Ordered Locus Names:Mhun_0734
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004177471 – 95CRISPR-associated endoribonuclease Cas2 1Add BLAST95

Interactioni

Subunit structurei

Homodimer, forms a heterotetramer with a Cas1 homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi323259.Mhun_0734

Structurei

3D structure databases

ProteinModelPortaliQ2FL79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04194 Archaea
COG1343 LUCA
OrthoDBiPOG093Z0JHJ

Family and domain databases

HAMAPiMF_01471 Cas2, 1 hit
InterProiView protein in InterPro
IPR021127 CRISPR_associated_Cas2
IPR019199 Virulence_VapD/CRISPR_Cas2
PANTHERiPTHR34405 PTHR34405, 1 hit
PfamiView protein in Pfam
PF09827 CRISPR_Cas2, 1 hit
TIGRFAMsiTIGR01573 cas2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FL79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVKHLIVCY DVEKTKDRNK VIKVLEYYGL IRVQYSVFMG SLTETRLHQM
60 70 80 90
NARIKREFTK PSIKILVIEV CNACMERALL VHEELPKVNR QFEVI
Length:95
Mass (Da):11,239
Last modified:March 21, 2006 - v1
Checksum:iC8E8F03250D81AEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD40487.1
RefSeqiWP_011447766.1, NC_007796.1

Genome annotation databases

EnsemblBacteriaiABD40487; ABD40487; Mhun_0734
GeneIDi3923161
KEGGimhu:Mhun_0734

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD40487.1
RefSeqiWP_011447766.1, NC_007796.1

3D structure databases

ProteinModelPortaliQ2FL79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323259.Mhun_0734

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD40487; ABD40487; Mhun_0734
GeneIDi3923161
KEGGimhu:Mhun_0734

Phylogenomic databases

eggNOGiarCOG04194 Archaea
COG1343 LUCA
OrthoDBiPOG093Z0JHJ

Enzyme and pathway databases

BioCyciMHUN323259:G1G5Z-782-MONOMER

Family and domain databases

HAMAPiMF_01471 Cas2, 1 hit
InterProiView protein in InterPro
IPR021127 CRISPR_associated_Cas2
IPR019199 Virulence_VapD/CRISPR_Cas2
PANTHERiPTHR34405 PTHR34405, 1 hit
PfamiView protein in Pfam
PF09827 CRISPR_Cas2, 1 hit
TIGRFAMsiTIGR01573 cas2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAS2A_METHJ
AccessioniPrimary (citable) accession number: Q2FL79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: March 21, 2006
Last modified: February 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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