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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. no protein annotated in this organism
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei81Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei89PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi93Magnesium 1UniRule annotation1
Binding sitei112Anthranilate 1UniRule annotation1
Binding sitei121Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei167Anthranilate 2UniRule annotation1
Metal bindingi225Magnesium 2UniRule annotation1
Metal bindingi226Magnesium 1UniRule annotation1
Metal bindingi226Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMHUN323259:G1G5Z-1895-MONOMER
UniPathwayi
UPA00035;UER00041

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Mhun_1787
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000430301 – 334Anthranilate phosphoribosyltransferaseAdd BLAST334

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi323259.Mhun_1787

Structurei

3D structure databases

ProteinModelPortaliQ2FKX5
SMRiQ2FKX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni91 – 94Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni109 – 117Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02012 Archaea
COG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiPOG093Z0D7V

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FKX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQDTIRKVV SMQDLAPDEA RDLMTSIADG KVTDAQIGSI LTALSMKGVT
60 70 80 90 100
AHEITAFAHV LRDRAVQLKT DTSGTFVDTC GTGGDGAHTF NISTAAALVA
110 120 130 140 150
AAAGVRVVKH GNRGVSSRSG SADVLEALGI PITLTPEEAA ASVSSHNIAF
160 170 180 190 200
LFAPGYHPAI GRVASARREI GFFSVFNILG PLLNPAGASA RLIGVGDTRH
210 220 230 240 250
IPSITGALAN LGVSHAMVVH GDGTDEITIT GETEVYELSG GTICRYTLTP
260 270 280 290 300
EEFGIRRVSR ETIAGGSPAE NAEIIMDIFS GRKGPCRDIV LLNAAAAIYL
310 320 330
GEKATCIYDG YRIAREVVDS GQAYRLVMAL RRTT
Length:334
Mass (Da):34,995
Last modified:March 21, 2006 - v1
Checksum:i40C6749E52DD8743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD41508.1
RefSeqiWP_011448772.1, NC_007796.1

Genome annotation databases

EnsemblBacteriaiABD41508; ABD41508; Mhun_1787
GeneIDi3924369
KEGGimhu:Mhun_1787

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD41508.1
RefSeqiWP_011448772.1, NC_007796.1

3D structure databases

ProteinModelPortaliQ2FKX5
SMRiQ2FKX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323259.Mhun_1787

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD41508; ABD41508; Mhun_1787
GeneIDi3924369
KEGGimhu:Mhun_1787

Phylogenomic databases

eggNOGiarCOG02012 Archaea
COG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiPOG093Z0D7V

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00041

BioCyciMHUN323259:G1G5Z-1895-MONOMER

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_METHJ
AccessioniPrimary (citable) accession number: Q2FKX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: October 10, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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