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Protein

Alanine dehydrogenase 1

Gene

ald1

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.By similarity

Catalytic activityi

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH.

Pathwayi: L-alanine degradation via dehydrogenase pathway

This protein is involved in step 1 of the subpathway that synthesizes NH(3) and pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine dehydrogenase 2 (ald2), Alanine dehydrogenase 1 (ald1)
This subpathway is part of the pathway L-alanine degradation via dehydrogenase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NH(3) and pyruvate from L-alanine, the pathway L-alanine degradation via dehydrogenase pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 200NADBy similarityAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00527; UER00585

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine dehydrogenase 1 (EC:1.4.1.1)
Gene namesi
Name:ald1
Ordered Locus Names:SAUSA300_1331
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001939 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002873221 – 372Alanine dehydrogenase 1Add BLAST372

Proteomic databases

PRIDEiQ2FH00

Structurei

3D structure databases

ProteinModelPortaliQ2FH00
SMRiQ2FH00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AlaDH/PNT family.Curated

Phylogenomic databases

HOGENOMiHOG000022120
KOiK00259
OMAiTCFAMER

Family and domain databases

CDDicd05305 L-AlaDH, 1 hit
InterProiView protein in InterPro
IPR008141 Ala_DH
IPR008143 Ala_DH/PNT_CS2
IPR008142 AlaDH/PNT_CS1
IPR007886 AlaDH/PNT_N
IPR007698 AlaDH/PNT_NAD(H)-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR42795 PTHR42795, 1 hit
PfamiView protein in Pfam
PF01262 AlaDh_PNT_C, 1 hit
PF05222 AlaDh_PNT_N, 1 hit
PIRSFiPIRSF000183 Alanine_dh, 1 hit
SMARTiView protein in SMART
SM01002 AlaDh_PNT_C, 1 hit
SM01003 AlaDh_PNT_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00518 alaDH, 1 hit
PROSITEiView protein in PROSITE
PS00836 ALADH_PNT_1, 1 hit
PS00837 ALADH_PNT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FH00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVAVVKELK QGEGRVACTP ENVRKLTDAG HKVIVEKNAG IGSGFSNDMY
60 70 80 90 100
EKEGAKIVTH EQAWEADLVI KVKEPHESEY QYFKKNQIIW GFLHLASSKE
110 120 130 140 150
IVEKMQEVGV TAISGETIIK NGKAELLAPM SAIAGQRSAI MGAYYSEAQH
160 170 180 190 200
GGQGTLVTGV HENVDIPGST YVIFGGGVAA TNAANVALGL NAKVIIIELN
210 220 230 240 250
DDRIKYLEDM YAEKDVTVVK STPENLAEQI KKADVFISTI LIPGAKPPKL
260 270 280 290 300
VTREMVKSMK KGSVLIDIAI DQGGTIETIR PTTISDPVYE EEGVIHYGVP
310 320 330 340 350
NQPGAVPRTS TMALAQGNID YILEICDKGL EQAIKDNEAL STGVNIYQGQ
360 370
VTNQGLASSH DLDYKEILNV IE
Length:372
Mass (Da):40,235
Last modified:March 21, 2006 - v1
Checksum:iCAF521B4A8C5D8EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA Translation: ABD21351.1
RefSeqiWP_000959424.1, NZ_CP027476.1

Genome annotation databases

EnsemblBacteriaiABD21351; ABD21351; SAUSA300_1331
KEGGisaa:SAUSA300_1331

Similar proteinsi

Entry informationi

Entry nameiDHA1_STAA3
AccessioniPrimary (citable) accession number: Q2FH00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 21, 2006
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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