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Protein

Alanine dehydrogenase 2

Gene

ald2

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.By similarity

Catalytic activityi

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH.

Pathwayi: L-alanine degradation via dehydrogenase pathway

This protein is involved in step 1 of the subpathway that synthesizes NH(3) and pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine dehydrogenase 2 (ald2), Alanine dehydrogenase 1 (ald1)
This subpathway is part of the pathway L-alanine degradation via dehydrogenase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NH(3) and pyruvate from L-alanine, the pathway L-alanine degradation via dehydrogenase pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 199NADBy similarityAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00527; UER00585.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine dehydrogenase 2 (EC:1.4.1.1)
Gene namesi
Name:ald2
Ordered Locus Names:SAUSA300_1655
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001939 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002873231 – 372Alanine dehydrogenase 2Add BLAST372

Proteomic databases

PRIDEiQ2FG29.

Structurei

3D structure databases

ProteinModelPortaliQ2FG29.
SMRiQ2FG29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AlaDH/PNT family.Curated

Phylogenomic databases

HOGENOMiHOG000022120.
KOiK00259.
OMAiCFETSKA.

Family and domain databases

CDDicd05305. L-AlaDH. 1 hit.
InterProiView protein in InterPro
IPR008141. Ala_DH.
IPR008143. Ala_DH/PNT_CS2.
IPR008142. AlaDH/PNT_CS1.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR42795. PTHR42795. 1 hit.
PfamiView protein in Pfam
PF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
PIRSFiPIRSF000183. Alanine_dh. 1 hit.
SMARTiView protein in SMART
SM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00518. alaDH. 1 hit.
PROSITEiView protein in PROSITE
PS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FG29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGIPREIK NNENRVGLSP SGVHALVESG HTVLVETNAG SGSFFEDVDY
60 70 80 90 100
KEAGAEIVAE QAKVWDVDMV IKVKEPLESE YPYFKEGLVL FTYLHLANEE
110 120 130 140 150
KLTQALIDRK VISIAYETVQ LPDRSLPLLS PMSEVAGRMS AQVGAEFLQK
160 170 180 190 200
LNGGMGILLG GVPGVPKGKV TIIGGGQAGT NAAKIALGLG ADVTILDVNP
210 220 230 240 250
KRLQQLDDLF GGRVHTIMSN PLNIELYVKQ SDLVIGAVLI PGAKAPRLVT
260 270 280 290 300
EDMIKQMKNG SVIIDIAIDQ GGIFETTDKI TTHDDPTYIK HGVVHYAVAN
310 320 330 340 350
MPGAVPRTST LALNNATLPY ALMLANKGYR EAFKSNQPLS LGLNTYKGHV
360 370
TNKGVAEAFE MEYKSVEEAL QL
Length:372
Mass (Da):40,105
Last modified:March 21, 2006 - v1
Checksum:i32BA3DA4734EC9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21879.1.

Genome annotation databases

EnsemblBacteriaiABD21879; ABD21879; SAUSA300_1655.
KEGGisaa:SAUSA300_1655.

Similar proteinsi

Entry informationi

Entry nameiDHA2_STAA3
AccessioniPrimary (citable) accession number: Q2FG29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 21, 2006
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome