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UniProtKB - Q2FEZ8 (COAW_STAA3)
Protein
Type II pantothenate kinase
Gene
coaW
Organism
Staphylococcus aureus (strain USA300)
Status
Functioni
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
UniRule annotationCatalytic activityi
- EC:2.7.1.33UniRule annotation
: coenzyme A biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 70 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 99 | ATPUniRule annotation | 1 | |
Binding sitei | 137 | ATPUniRule annotation | 1 | |
Binding sitei | 225 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 6 – 13 | ATPUniRule annotation | 8 | |
Nucleotide bindingi | 121 – 125 | ATPUniRule annotation | 5 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- pantothenate kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- coenzyme A biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Coenzyme A biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00241;UER00352 |
Names & Taxonomyi
Protein namesi | Recommended name: Type II pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)Alternative name(s): PanK-IIUniRule annotation Pantothenic acid kinaseUniRule annotation |
Gene namesi | Name:coaWUniRule annotation Synonyms:coaA Ordered Locus Names:SAUSA300_2084 |
Organismi | Staphylococcus aureus (strain USA300) |
Taxonomic identifieri | 367830 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261351 | 1 – 267 | Type II pantothenate kinaseAdd BLAST | 267 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
DIPi | DIP-29151N |
Family & Domainsi
Sequence similaritiesi
Belongs to the type II pantothenate kinase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_087521_1_0_9 |
OMAi | VKHIYKD |
Family and domain databases
HAMAPi | MF_01273, Pantothen_kinase_2, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR004567, Type_II_PanK IPR011602, Type_II_PanK_bac |
PANTHERi | PTHR12280, PTHR12280, 1 hit |
Pfami | View protein in Pfam PF03630, Fumble, 1 hit |
PIRSFi | PIRSF036940, PanK_bac_aCoA, 1 hit |
SUPFAMi | SSF53067, SSF53067, 1 hit |
TIGRFAMsi | TIGR00555, panK_eukar, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2FEZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVGIDAGGT LIKIVQEQDN QRTFKTELTK NIDQVVEWLN QQQIEKLCLT
60 70 80 90 100
GGNAGVIAEN INIPAQIFVE FDAASQGLGI LLKEQGHDLA DYIFANVGTG
110 120 130 140 150
TSLHYFDGQS QRRVGGIGTG GGMIQGLGYL LSQITDYKQL TDMAQHGDRN
160 170 180 190 200
TIDLKVRHIY KDTEPPIPGD LTAANFGHVL HHLDADFTPS NKLAAVIGVV
210 220 230 240 250
GEVVTTMAIT VAREFKTENI VYIGSSFHNN ALLRKVVEDY TVLRGCKPYY
260
VENGAFSGAI GALYLEK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000255 Genomic DNA Translation: ABD22282.1 |
Genome annotation databases
EnsemblBacteriai | ABD22282; ABD22282; SAUSA300_2084 |
KEGGi | saa:SAUSA300_2084 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000255 Genomic DNA Translation: ABD22282.1 |
3D structure databases
SMRi | Q2FEZ8 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-29151N |
Genome annotation databases
EnsemblBacteriai | ABD22282; ABD22282; SAUSA300_2084 |
KEGGi | saa:SAUSA300_2084 |
Phylogenomic databases
HOGENOMi | CLU_087521_1_0_9 |
OMAi | VKHIYKD |
Enzyme and pathway databases
UniPathwayi | UPA00241;UER00352 |
Family and domain databases
HAMAPi | MF_01273, Pantothen_kinase_2, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR004567, Type_II_PanK IPR011602, Type_II_PanK_bac |
PANTHERi | PTHR12280, PTHR12280, 1 hit |
Pfami | View protein in Pfam PF03630, Fumble, 1 hit |
PIRSFi | PIRSF036940, PanK_bac_aCoA, 1 hit |
SUPFAMi | SSF53067, SSF53067, 1 hit |
TIGRFAMsi | TIGR00555, panK_eukar, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COAW_STAA3 | |
Accessioni | Q2FEZ8Primary (citable) accession number: Q2FEZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | March 21, 2006 | |
Last modified: | February 23, 2022 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families