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Entry version 72 (17 Jun 2020)
Sequence version 1 (21 Mar 2006)
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Protein

Efflux pump membrane transporter

Gene

adeG

Organism
Acinetobacter baumannii
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportUniRule annotation

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.2.44 the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Efflux pump membrane transporterUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:adeGImported
ORF Names:29_167Imported, ABUW_1335Imported, DLI69_16720Imported, FDO31_01925Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcinetobacter baumanniiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri470 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000326007 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000325747 Componenti: Unassembled WGS sequence
  • UP000032746 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 34HelicalUniRule annotationAdd BLAST23
Transmembranei340 – 360HelicalUniRule annotationAdd BLAST21
Transmembranei367 – 387HelicalUniRule annotationAdd BLAST21
Transmembranei393 – 417HelicalUniRule annotationAdd BLAST25
Transmembranei438 – 458HelicalUniRule annotationAdd BLAST21
Transmembranei470 – 497HelicalUniRule annotationAdd BLAST28
Transmembranei548 – 569HelicalUniRule annotationAdd BLAST22
Transmembranei878 – 896HelicalUniRule annotationAdd BLAST19
Transmembranei903 – 925HelicalUniRule annotationAdd BLAST23
Transmembranei931 – 954HelicalUniRule annotationAdd BLAST24
Transmembranei975 – 995HelicalUniRule annotationAdd BLAST21
Transmembranei1007 – 1034HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini366 – 495SSDInterPro annotationAdd BLAST130

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZS Bacteria
COG0841 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004764 HAE1
IPR000731 SSD

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00915 2A0602, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2FD81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNISKFFIDR PIFAGVLSVL ILLAGLLSVF QLPISEYPEV VPPSVVVRAQ
60 70 80 90 100
YPGANPKVIA ETVASPLEES INGVEDMLYM QSQANSDGNL TITVNFKLGI
110 120 130 140 150
DPDKAQQLVQ NRVSQAMPRL PEDVQRLGVT TLKSSPTLTM VVHLTSPDNR
160 170 180 190 200
YDMTYLRNYA VLNVKDRLAR LQGVGEVGLF GSGDYAMRVW LDPQKVAQRN
210 220 230 240 250
LTATEIVNAI REQNIQVAAG TIGASPSNSP LQLSVNAQGR LTTEQEFADI
260 270 280 290 300
ILKTAPDGAV TRLGDVARVE LAASQYGLRS LLDNKQAVAI PIFQAPGANA
310 320 330 340 350
LQVSDQVRST MKELSKDFPS SIKYDIVYDP TQFVRASIKA VVHTLLEAIT
360 370 380 390 400
LVVVVVILFL QTWRASIIPL LAVPVSIIGT FALMLAFGYS INALSLFGMV
410 420 430 440 450
LAIGIVVDDA IVVVENVERN IEAGLNPREA TYRAMREVSG PIIAIALTLV
460 470 480 490 500
AVFVPLAFMT GLTGQFYKQF AMTIAISTVI SAFNSLTLSP ALAALLLKGH
510 520 530 540 550
DAKPDALTRI MNRVFGRFFA LFNRVFSRAS DRYSQGVSRV ISHKASAMGV
560 570 580 590 600
YAALLGLTVG ISYIVPGGFV PAQDKQYLIS FAQLPNGASL DRTEAVIRKM
610 620 630 640 650
SDTALKQPGV ESAVAFPGLS INGFTNSSSA GIVFVTLKPF DERKAKDLSA
660 670 680 690 700
NAIAGALNQK YSAIQDAYIA VFPPPPVMGL GTMGGFKLQL EDRGALGYSA
710 720 730 740 750
LNDAAQNFMK AAQSAPELGP MFSSYQINVP QLNVDLDRVK AKQQGVAVTD
760 770 780 790 800
VFNTMQIYLG SQYVNDFNRF GRVYQVRAQA DAPFRANPED ILQLKTRNSA
810 820 830 840 850
GQMVPLSSLV NVTQTYGPEM VVRYNGYTSA DINGGPAPGY SSSQAEAAVE
860 870 880 890 900
RIAAQTLPRG IKFEWTDLTY QKILAGNAGL WVFPISVLLV FLVLAAQYES
910 920 930 940 950
LTLPLAVILI VPMGILAALT GVWLTAGDNN IFTQIGLMVL VGLACKNAIL
960 970 980 990 1000
IVEFARELEM QGATAFKAAV EASRLRLRPI LMTSIAFIMG VVPLVTSTGA
1010 1020 1030 1040 1050
GSEMRHAMGV AVFFGMIGVT FFGLFLTPAF YVLIRTLNSK HKLHSAAVHE

APLASPHDH
Length:1,059
Mass (Da):114,214
Last modified:March 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C3C8AB04DA9EEEE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP008706 Genomic DNA Translation: AKA31081.1
CT025801 Genomic DNA Translation: CAJ77856.1
VJZY01000002 Genomic DNA Translation: KAB8134625.1
CP045541 Genomic DNA Translation: QFV04771.1

NCBI Reference Sequences

More...
RefSeqi
WP_001027069.1, NZ_WIVM01000006.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AKA31081; AKA31081; ABUW_1335

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|470.1314.peg.3663

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP008706 Genomic DNA Translation: AKA31081.1
CT025801 Genomic DNA Translation: CAJ77856.1
VJZY01000002 Genomic DNA Translation: KAB8134625.1
CP045541 Genomic DNA Translation: QFV04771.1
RefSeqiWP_001027069.1, NZ_WIVM01000006.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.6.2.44 the resistance-nodulation-cell division (rnd) superfamily

Genome annotation databases

EnsemblBacteriaiAKA31081; AKA31081; ABUW_1335
PATRICifig|470.1314.peg.3663

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004764 HAE1
IPR000731 SSD
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits
TIGRFAMsiTIGR00915 2A0602, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2FD81_ACIBA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2FD81
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: June 17, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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