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Entry version 88 (29 Sep 2021)
Sequence version 1 (21 Mar 2006)
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Protein
Submitted name:

Efflux transporter, RND family, MFP subunit

Gene

macA

Organism
Acinetobacter baumannii
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.122.18, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Efflux transporter, RND family, MFP subunitImported
Submitted name:
MacA family efflux pump subunitImported
Submitted name:
Membrane-fusion proteinImported
Submitted name:
Putative RND family drug transporterImported
Submitted name:
Secretion protein HylDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:macAImported
Synonyms:macA_1Imported, macA_3Imported
ORF Names:9_130Imported, Aba9201_10970Imported, ABUW_3362Imported, APC21_18375Imported, C6N18_03440Imported, EGM95_17945Imported, FQK04_15655Imported, GNY86_09175Imported, GUK62_01190Imported, HIN86_16990Imported, NCTC13421_03301Imported, SAMEA104305318_00087Imported, SI89_14255Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcinetobacter baumanniiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri470 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000439424 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000032746 Componenti: Chromosome
  • UP000476174 Componenti: Unassembled WGS sequence
  • UP000501210 Componenti: Chromosome
  • UP000050848 Componenti: Unassembled WGS sequence
  • UP000320356 Componenti: Unassembled WGS sequence
  • UP000252694 Componenti: Unassembled WGS sequence
  • UP000261834 Componenti: Chromosome
  • UP000249678 Componenti: Chromosome 1
  • UP000460226 Componenti: Unassembled WGS sequence
  • UP000238600 Componenti: Chromosome
  • UP000273577 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Lipoprotein, PalmitateARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 249HlyD_D23InterPro annotationAdd BLAST198

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni329 – 358DisorderedSequence analysisAdd BLAST30
Regioni425 – 445DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili108 – 128Sequence analysisAdd BLAST21
Coiled coili146 – 173Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi329 – 352Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. [View classification]ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032317, HlyD_D23
IPR006143, RND_pump_MFP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16576, HlyD_D23, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01730, RND_mfp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2FD52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKIKPIKLV IIVVCIAIIA VLAWKFLKPK QQQPQYITAE VTRGDIENNV
60 70 80 90 100
LATGTLDATK LISVGAQVSG QVKKMYVQLG DQVKQGQLIA QIDSTTQENS
110 120 130 140 150
LKTSDANIKN LEAQRLQQIA SLNEKQLEYR RQQQMYAQDA TPRADLESAE
160 170 180 190 200
AAYKTAQAQV KALDAQIESA KITRSTAQTN IGYTRIVAPT DGTVVAIVTE
210 220 230 240 250
EGQTVNANQS APTIVKIAKL QNMTIKAQVS EADIMKVEKG QQVYFTTLGD
260 270 280 290 300
ETKRYATLRQ IEPAPDSISS ESNSTTSSTT SSAVYYNALF DVPNTDGKLR
310 320 330 340 350
IDMTAQVYIV LNSAKNALLV PSSALSSKQF SGQRKQGQSA DKASSTPSAE
360 370 380 390 400
RKHQGNGVRL ERLNLTPEQK QLIEQGKATL SVVRVLQADG TTKPTQILVG
410 420 430 440
INNRVNAQVL AGLKQGDQVV IADSSENSAA SANSGNNRRR GPMGM
Length:445
Mass (Da):48,145
Last modified:March 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2A2D25CDE8D3C40
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP008706 Genomic DNA Translation: AKA33058.1
CP027246 Genomic DNA Translation: AVN13238.1
CP023020 Genomic DNA Translation: AXX41506.1
CP033869 Genomic DNA Translation: AYY90518.1
CT025830 Genomic DNA Translation: CAJ77825.1
LLHX01000076 Genomic DNA Translation: KQF80348.1
WPIP01000053 Genomic DNA Translation: MVM91691.1
WYAB01000001 Genomic DNA Translation: MZY44930.1
WKJR01000041 Genomic DNA Translation: NBG85730.1
CP051875 Genomic DNA Translation: QJF36800.1
LS483472 Genomic DNA Translation: SQI58530.1
UFMQ01000001 Genomic DNA Translation: SST15429.1
VNWR01000052 Genomic DNA Translation: TWO44744.1

NCBI Reference Sequences

More...
RefSeqi
WP_001124213.1, NZ_WYAT01000012.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AKA33058; AKA33058; ABUW_3362
ASF75993; ASF75993; CBI29_00596
AYY90518; AYY90518; EGM95_17945
SST15429; SST15429; SAMEA104305318_00087
SVJ97311; SVJ97311; SAMEA104305242_01662

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
abau:IX87_17185
abk:LX00_02675

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|470.1295.peg.3379

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP008706 Genomic DNA Translation: AKA33058.1
CP027246 Genomic DNA Translation: AVN13238.1
CP023020 Genomic DNA Translation: AXX41506.1
CP033869 Genomic DNA Translation: AYY90518.1
CT025830 Genomic DNA Translation: CAJ77825.1
LLHX01000076 Genomic DNA Translation: KQF80348.1
WPIP01000053 Genomic DNA Translation: MVM91691.1
WYAB01000001 Genomic DNA Translation: MZY44930.1
WKJR01000041 Genomic DNA Translation: NBG85730.1
CP051875 Genomic DNA Translation: QJF36800.1
LS483472 Genomic DNA Translation: SQI58530.1
UFMQ01000001 Genomic DNA Translation: SST15429.1
VNWR01000052 Genomic DNA Translation: TWO44744.1
RefSeqiWP_001124213.1, NZ_WYAT01000012.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi3.A.1.122.18, the atp-binding cassette (abc) superfamily

Genome annotation databases

EnsemblBacteriaiAKA33058; AKA33058; ABUW_3362
ASF75993; ASF75993; CBI29_00596
AYY90518; AYY90518; EGM95_17945
SST15429; SST15429; SAMEA104305318_00087
SVJ97311; SVJ97311; SAMEA104305242_01662
KEGGiabau:IX87_17185
abk:LX00_02675
PATRICifig|470.1295.peg.3379

Family and domain databases

InterProiView protein in InterPro
IPR032317, HlyD_D23
IPR006143, RND_pump_MFP
PfamiView protein in Pfam
PF16576, HlyD_D23, 1 hit
TIGRFAMsiTIGR01730, RND_mfp, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2FD52_ACIBA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2FD52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: September 29, 2021
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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