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Protein

Phosphothreonine lyase OspF

Gene

ospF

Organism
Shigella boydii
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of proinflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82Proton donorBy similarity1
Active sitei112Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphothreonine lyase OspF (EC:4.2.3.-)
Alternative name(s):
Effector protein OspF
Gene namesi
Name:ospF
Encoded oniPlasmid pSb17_G12141 Publication
Plasmid pSb2_G11841 Publication
Plasmid pSb3_G12321 Publication
Plasmid pSb6_G12271 Publication
Plasmid pSb7_G11871 Publication
Plasmid pSb8_G12681 Publication
Plasmid pSb9_G12361 Publication
Plasmid pSb1_G12281 Publication
Plasmid pSb10_G12941 Publication
Plasmid pSb11_G11911 Publication
Plasmid pSb12_G12871 Publication
Plasmid pSb14_G13001 Publication
Plasmid pSb15_G12821 Publication
OrganismiShigella boydii
Taxonomic identifieri621 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella

Subcellular locationi

  • Secreted
  • Note: Secreted via the type III secretion system (TTSS). Localizes in the nucleus of the infected cell (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000299350‹1 – ›170Phosphothreonine lyase OspFAdd BLAST›170

Structurei

3D structure databases

SMRiQ2ET28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphothreonine lyase family.Curated

Family and domain databases

Gene3Di3.30.2430.10, 1 hit
InterProiView protein in InterPro
IPR003519 OspF/SpvC
IPR038498 OspF/SpvC_sf
PfamiView protein in Pfam
PF03536 VRP3, 1 hit
PRINTSiPR01342 SALVRPPROT

Sequencei

Sequence statusi: Fragment.

Q2ET28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PQMLSANERL KNNFNILYNQ IRQYPAYYFK VASNVPTYSD ICQFFSVMYQ
60 70 80 90 100
GFQIVNHSGD VFIHACRENP QSKGDFVGDK FHISIAREQV PLAFQILSGL
110 120 130 140 150
LFSEDSPIDK WKITDMNRVS QQSRVGIGAQ FTLYVKSDQE CSQYSALLLH
160 170
KIRQFIMCLE SNLLRSKIAP
Length:170
Mass (Da):19,585
Last modified:March 21, 2006 - v1
Checksum:iB2D0850BF4172738
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1701

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ362851 Genomic DNA Translation: ABD37258.1
DQ362852 Genomic DNA Translation: ABD37259.1
DQ362853 Genomic DNA Translation: ABD37260.1
DQ362854 Genomic DNA Translation: ABD37261.1
DQ362855 Genomic DNA Translation: ABD37262.1
DQ362856 Genomic DNA Translation: ABD37263.1
DQ362857 Genomic DNA Translation: ABD37264.1
DQ362858 Genomic DNA Translation: ABD37265.1
DQ362859 Genomic DNA Translation: ABD37266.1
DQ362860 Genomic DNA Translation: ABD37267.1
DQ362861 Genomic DNA Translation: ABD37268.1
DQ362862 Genomic DNA Translation: ABD37269.1
DQ362863 Genomic DNA Translation: ABD37270.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ362851 Genomic DNA Translation: ABD37258.1
DQ362852 Genomic DNA Translation: ABD37259.1
DQ362853 Genomic DNA Translation: ABD37260.1
DQ362854 Genomic DNA Translation: ABD37261.1
DQ362855 Genomic DNA Translation: ABD37262.1
DQ362856 Genomic DNA Translation: ABD37263.1
DQ362857 Genomic DNA Translation: ABD37264.1
DQ362858 Genomic DNA Translation: ABD37265.1
DQ362859 Genomic DNA Translation: ABD37266.1
DQ362860 Genomic DNA Translation: ABD37267.1
DQ362861 Genomic DNA Translation: ABD37268.1
DQ362862 Genomic DNA Translation: ABD37269.1
DQ362863 Genomic DNA Translation: ABD37270.1

3D structure databases

SMRiQ2ET28
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.2430.10, 1 hit
InterProiView protein in InterPro
IPR003519 OspF/SpvC
IPR038498 OspF/SpvC_sf
PfamiView protein in Pfam
PF03536 VRP3, 1 hit
PRINTSiPR01342 SALVRPPROT
ProtoNetiSearch...

Entry informationi

Entry nameiOSPF_SHIBO
AccessioniPrimary (citable) accession number: Q2ET28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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