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Entry version 123 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Protein mono-ADP-ribosyltransferase PARP14

Gene

Parp14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (By similarity).By similarity1 Publication1 Publication

Caution

The role of PARP14-mediated ADP-ribosylation of STAT1 in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei835Substrate 1By similarity1
Binding sitei844Substrate 1; via amide nitrogenBy similarity1
Binding sitei1045Substrate 2By similarity1
Binding sitei1258Substrate 3By similarity1
Binding sitei1269Substrate 3; via amide nitrogenBy similarity1
Binding sitei1382Substrate 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processImmunity, Innate immunity, Transcription, Transcription regulation
LigandNAD

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-197264 Nicotinamide salvaging

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mono-ADP-ribosyltransferase PARP14Curated (EC:2.4.2.-1 Publication)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 8
Short name:
ARTD8
Collaborator of STAT61 Publication
Short name:
CoaSt61 Publication
Poly [ADP-ribose] polymerase 14
Short name:
PARP-14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Parp14Imported
Synonyms:Kiaa12681 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919489 Parp14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002475901 – 1817Protein mono-ADP-ribosyltransferase PARP14Add BLAST1817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33PhosphoserineBy similarity1
Modified residuei1419PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ADP-ribosylated.By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2EMV9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2EMV9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2EMV9

PeptideAtlas

More...
PeptideAtlasi
Q2EMV9

PRoteomics IDEntifications database

More...
PRIDEi
Q2EMV9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2EMV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2EMV9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q2EMV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in the thymus during development and in adulthood (PubMed:18069692). Expressed in macrophages (PubMed:27796300).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IFNG in macrophages. Down-regulated by IL4 in macrophages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034422 Expressed in 171 organ(s), highest expression level in lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2EMV9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STAT6 (PubMed:16537510).

Interacts with PARP10 (By similarity).

Interacts with PARP9 in IFNG-stimulated macrophages; the interaction prevents PARP14-mediated STAT1 and STAT6 ADP-riboslylation (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
246104, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-38053N

Protein interaction database and analysis system

More...
IntActi
Q2EMV9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000037657

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11817
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2EMV9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q2EMV9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini802 – 989Macro 1PROSITE-ProRule annotationAdd BLAST188
Domaini1014 – 1202Macro 2PROSITE-ProRule annotationAdd BLAST189
Domaini1227 – 1398Macro 3PROSITE-ProRule annotationAdd BLAST172
Domaini1539 – 1617WWEPROSITE-ProRule annotationAdd BLAST79
Domaini1621 – 1817PARP catalyticPROSITE-ProRule annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni933 – 937Substrate 1 bindingBy similarity5
Regioni1034 – 1035Substrate 2 bindingBy similarity2
Regioni1057 – 1060Substrate 2 bindingBy similarity4
Regioni1145 – 1149Substrate 2 bindingBy similarity5
Regioni1187 – 1190Substrate 2 bindingBy similarity4
Regioni1246 – 1247Substrate 3 bindingBy similarity2
Regioni1343 – 1347Substrate 3 bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi771 – 800Glu-richAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2633 Eukaryota
COG2110 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154311

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168887

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2EMV9

KEGG Orthology (KO)

More...
KOi
K15261

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVYKVKC

Database of Orthologous Groups

More...
OrthoDBi
1253228at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328965

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12543 RRM2_PAR14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002589 Macro_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034517 PAR14_RRM2
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01661 Macro, 3 hits
PF00644 PARP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506 A1pp, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839 SSF117839, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51154 MACRO, 3 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q2EMV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASGSFPLL VEGSWGPDPP KNLINKLQVY FQSRKKSGGG ECEVVPEPGN
60 70 80 90 100
PARFRVLFSP EDVRQNVLER GNHELVWQEK GTFKLTVLMP TDPEEASASK
110 120 130 140 150
KSRKESPEEE SKTKEDAVKQ GDLDITHSPS SGSEKTEDVP KECENISSMV
160 170 180 190 200
AFENLPEKVS EMVLTILVEN ISGLPSDDFK VEVNRDFAVA VVTFQKPIDI
210 220 230 240 250
KKFIVDCISH RSNQQLQLAP RLLETTNVVR VENLPPGVDE YQLQLFFENP
260 270 280 290 300
FNGGGRVARV ECFPEESSAL VEFCDSKVLD TVMAKTHSYN KMPLSVFPYY
310 320 330 340 350
PSLGTALYGE EKPLIKLPAS FQESLDLPLW KFFQKNNHLI EEINNEMRCC
360 370 380 390 400
HCELTWSEIN GKLTIRPAAT LVNHRLSIKT WQRDASAVLS GIKSKYGVEL
410 420 430 440 450
FEVCSPVWDI IKHELESGDD RVLVEFEKES LNIAGKSEDV QGMSQKIREL
460 470 480 490 500
IESTTEKLRR EEQSLKEKVA ISPGKHYLLH HSGFLKDLSK GFPEMEISYD
510 520 530 540 550
ATAQFLYLKG FRADVYKVKC DIQEKVFSMA QKDVQVSSEV FEFLQQVDSQ
560 570 580 590 600
RLSKSLFEAQ NILAIYELKG TALFLVGSSF KDLAEAETKM LSALSHKQIE
610 620 630 640 650
VEDKEVLISN GWKKKVHPLQ KRHSSCATII VQNELTSETP AKVIVTGCVK
660 670 680 690 700
EVNEIHRQLF EYLENNMKVE RALKIKPSLI VDYLRTDKRL LSKIKKAHVY
710 720 730 740 750
VHFKPKDNPN SILLTGCKSK VLECMNLVKE IQDSVCVQRF QTDKAGVRHF
760 770 780 790 800
FKDKESYYKT EIGRQFGCVI ELEEDREEKG EEEDGEEEEG EEEGESSINE
810 820 830 840 850
QKCHLQRDIA PGVKLFVLEE DLSRFPVDVV VNAANENLKH ISGLAQALSK
860 870 880 890 900
AAGPELQTEC DQIVKEGGVV LPGNAVISKA GKLPCHHVIH AVGPRWKGDK
910 920 930 940 950
VLECVSLLKK VVRQSLSLAE EHRCRSIAMP AVSAGIFDFP LELCVANIVS
960 970 980 990 1000
AIKEHFQHKR DTHTLKKIYL VGLPAKVARA FAEAVKTTYK DSLSHTAFPS
1010 1020 1030 1040 1050
SLKALVPLGK TPQKQGSLLV SPEGLRIRLV EEGVQNATTH AIVNSISPDL
1060 1070 1080 1090 1100
KLNKGPLSQA FLEKAGPKLQ EELTRSGQGV SVDVGTILQT SGCNLNSRHV
1110 1120 1130 1140 1150
FHVVPPPWKS NNSAWSLKIM KNIIRDCLKT TENLSLQSIA FPAIGTGNLR
1160 1170 1180 1190 1200
FPKPEFAKLI ISEVLKFSSR NQLKTLQEVQ FLLHPKDHEN IQAFSDEFDK
1210 1220 1230 1240 1250
RNNGDPSDKN PKAEDTQGIY GSLSSPTLGM HEMNIGPILF QVATGNIIKE
1260 1270 1280 1290 1300
VADVIVNSTT LTFDLKSGVS KAILEGAGQN VEQECSLLAK QSNHGYIVTG
1310 1320 1330 1340 1350
GGLLQCKNII HVVGGNDVKK SVSCVLEECE QRNYSSICLP AIGTGNAQQD
1360 1370 1380 1390 1400
PNVVAKAIID AIEEFVQKKS VQAVKRVKVV IFQPHILQFF YDNMKEREGS
1410 1420 1430 1440 1450
PAPPKQSPAK QSVMSKIASF LGFPKQASPK KNTLVLEKKI EHTVFQVCGS
1460 1470 1480 1490 1500
GVDSVNKTIS WLKELITKEQ LSYTNDDECV SDFDMEEYEK LNEIQKELNI
1510 1520 1530 1540 1550
TIEMNQKKTS IQVSGISRDV IKARDEIEGM IKSIRLAKEK ESQADYISTY
1560 1570 1580 1590 1600
VEWQYIDKNI TQCFDKMTNM KLEVAWKAKK KDTVVQIHNQ DFTVDLSTNT
1610 1620 1630 1640 1650
ATAPQGQTFT VQRLVKAEAE IPANWSDMKQ DKLLLVNLQT SDPEYNMVAS
1660 1670 1680 1690 1700
AFRQTCSNFF IEKIERIQNP ALWRRYQAYK KSMDEKNGNV RNEKHLFHGT
1710 1720 1730 1740 1750
EASSLPQLNS NGFNRSYAGK NATAYGKGTY FAVKASYSAC DTYSRPDTNG
1760 1770 1780 1790 1800
RKYMYYVRVL TGNYTNGNAS LIVPPSRDPQ NAADLYDTVT DNDKNPSIFV
1810
VFYDNQTYPE YLITFRQ
Length:1,817
Mass (Da):203,802
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42E902CC20858931
GO
Isoform 2 (identifier: Q2EMV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-589: Missing.

Show »
Length:1,228
Mass (Da):137,366
Checksum:i3E066E6F69CD4193
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21340 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH21340 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti708N → Y in ABD16173 (PubMed:16537510).Curated1
Sequence conflicti789E → K in BAC40943 (PubMed:16141072).Curated1
Sequence conflicti1045S → T in ABD16173 (PubMed:16537510).Curated1
Sequence conflicti1209K → E in BAC40943 (PubMed:16141072).Curated1
Sequence conflicti1609F → L in ABD16173 (PubMed:16537510).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1384P → S in strain: Czech II. 1 Publication1
Natural varianti1658N → D in strain: Czech II. 1 Publication1
Natural varianti1682S → G in strain: Czech II. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0200201 – 589Missing in isoform 2. 1 PublicationAdd BLAST589

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ372930 mRNA Translation: ABD16173.1
AC129574 Genomic DNA No translation available.
AK089685 mRNA Translation: BAC40943.1
AK220263 mRNA Translation: BAD90188.1
BC021340 mRNA Translation: AAH21340.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28143.1 [Q2EMV9-1]

NCBI Reference Sequences

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RefSeqi
NP_001034619.2, NM_001039530.3 [Q2EMV9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000042665; ENSMUSP00000037657; ENSMUSG00000034422 [Q2EMV9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
547253

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:547253

UCSC genome browser

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UCSCi
uc007zbs.2 mouse [Q2EMV9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ372930 mRNA Translation: ABD16173.1
AC129574 Genomic DNA No translation available.
AK089685 mRNA Translation: BAC40943.1
AK220263 mRNA Translation: BAD90188.1
BC021340 mRNA Translation: AAH21340.1 Different initiation.
CCDSiCCDS28143.1 [Q2EMV9-1]
RefSeqiNP_001034619.2, NM_001039530.3 [Q2EMV9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4RNMR-A1532-1617[»]
SMRiQ2EMV9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi246104, 4 interactors
DIPiDIP-38053N
IntActiQ2EMV9, 3 interactors
STRINGi10090.ENSMUSP00000037657

PTM databases

iPTMnetiQ2EMV9
PhosphoSitePlusiQ2EMV9
SwissPalmiQ2EMV9

Proteomic databases

EPDiQ2EMV9
MaxQBiQ2EMV9
PaxDbiQ2EMV9
PeptideAtlasiQ2EMV9
PRIDEiQ2EMV9

Genome annotation databases

EnsembliENSMUST00000042665; ENSMUSP00000037657; ENSMUSG00000034422 [Q2EMV9-1]
GeneIDi547253
KEGGimmu:547253
UCSCiuc007zbs.2 mouse [Q2EMV9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54625
MGIiMGI:1919489 Parp14

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2633 Eukaryota
COG2110 LUCA
GeneTreeiENSGT00940000154311
HOGENOMiHOG000168887
InParanoidiQ2EMV9
KOiK15261
OMAiDVYKVKC
OrthoDBi1253228at2759
TreeFamiTF328965

Enzyme and pathway databases

ReactomeiR-MMU-197264 Nicotinamide salvaging

Miscellaneous databases

EvolutionaryTraceiQ2EMV9

Protein Ontology

More...
PROi
PR:Q2EMV9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034422 Expressed in 171 organ(s), highest expression level in lung
GenevisibleiQ2EMV9 MM

Family and domain databases

CDDicd12543 RRM2_PAR14, 1 hit
Gene3Di3.30.70.330, 2 hits
3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR002589 Macro_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034517 PAR14_RRM2
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF01661 Macro, 3 hits
PF00644 PARP, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 3 hits
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 3 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAR14_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2EMV9
Secondary accession number(s): E9QP48
, Q571C6, Q8BN35, Q8VDT6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 123 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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