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Entry version 120 (22 Apr 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Polycystic kidney disease protein 1-like 3

Gene

Pkd1l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.5 Publications

Caution

Pkd1l3 and Pkd2l1 have been identified as sour taste receptor in gustatory cells based on a number of indirect evidences: Pkd2l1 is expressed in circumvallate papillae cells on the posterior part of the tongue distinct from those responsible for sweet, bitter and unami taste and genetic elimination of cells expressing Pkd2l1 reduces gustatory nerve responses to sour taste stimuli (PubMed:16891422, PubMed:16929298). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect: mice lacking Pkd1l3 do not show defects in sour taste perception (PubMed:20605874, PubMed:21625513). Moreover, the Pkd1l3-Pkd2l1 heteromer, when expressed in cells does not respond to acid stimuli used to evoke proton currents in taste cells (PubMed:21098668).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The calcium channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Lectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystic kidney disease protein 1-like 3
Alternative name(s):
PC1-like 3 protein
Polycystin-1L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkd1l3
ORF Names:71B10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2664670 Pkd1l3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 1083ExtracellularSequence analysisAdd BLAST1059
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1084 – 1104HelicalSequence analysisAdd BLAST21
Topological domaini1105 – 1293CytoplasmicSequence analysisAdd BLAST189
Transmembranei1294 – 1314HelicalSequence analysisAdd BLAST21
Topological domaini1315 – 1330ExtracellularSequence analysisAdd BLAST16
Transmembranei1331 – 1351HelicalSequence analysisAdd BLAST21
Topological domaini1352 – 1543CytoplasmicSequence analysisAdd BLAST192
Transmembranei1544 – 1564HelicalSequence analysisAdd BLAST21
Topological domaini1565 – 1585ExtracellularSequence analysisAdd BLAST21
Transmembranei1586 – 1606HelicalSequence analysisAdd BLAST21
Topological domaini1607 – 1666CytoplasmicSequence analysisAdd BLAST60
Transmembranei1667 – 1687HelicalSequence analysisAdd BLAST21
Topological domaini1688 – 1855ExtracellularSequence analysisAdd BLAST168
Transmembranei1856 – 1876HelicalSequence analysisAdd BLAST21
Topological domaini1877 – 1902CytoplasmicSequence analysisAdd BLAST26
Transmembranei1903 – 1923HelicalSequence analysisAdd BLAST21
Topological domaini1924 – 1944ExtracellularSequence analysisAdd BLAST21
Transmembranei1945 – 1965HelicalSequence analysisAdd BLAST21
Topological domaini1966 – 2032CytoplasmicSequence analysisAdd BLAST67
Transmembranei2033 – 2053HelicalSequence analysisAdd BLAST21
Topological domaini2054 – 2060ExtracellularSequence analysis7
Transmembranei2061 – 2078HelicalSequence analysisAdd BLAST18
Topological domaini2079 – 2098CytoplasmicSequence analysisAdd BLAST20
Transmembranei2099 – 2119HelicalSequence analysisAdd BLAST21
Topological domaini2120 – 2201ExtracellularSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No significant reduction in taste responsiveness: mice have normal nerve and behavioral responses to sour stimuli.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2059D → N: Little or no effect on calcium channel activity. 1 Publication1
Mutagenesisi2082E → Q: Little or no effect on calcium channel activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032257925 – 2201Polycystic kidney disease protein 1-like 3Add BLAST2177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 141PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi116 ↔ 133PROSITE-ProRule annotation
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi579N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi592N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi923N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi961N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2EG98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2EG98

PRoteomics IDEntifications database

More...
PRIDEi
Q2EG98

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2EG98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2EG98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a subset of taste receptor cells distinct from those involved in bitter, sweet and umami taste. Expressed in circumvallate and foliate taste buds, but not in surrounding non-gustatory lingual epithelium cells. Expressed in testis.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048827 Expressed in vallate papilla and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q2EG98 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Calcium channels are probably composed of 3 subunit of PKD2L1 and 1 subunit of PKD1L3.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
232669, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-61249N

Protein interaction database and analysis system

More...
IntActi
Q2EG98, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104865

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2EG98 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 142C-type lectinAdd BLAST109
Domaini1018 – 1067GPSPROSITE-ProRule annotationAdd BLAST50
Domaini1129 – 1246PLATPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2053 – 2091Channel pore-regionAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi236 – 602Ser-richAdd BLAST367

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599 Eukaryota
ENOG410YE1E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162813

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000913_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2EG98

KEGG Orthology (KO)

More...
KOi
K04989

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316484

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752 PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000203 GPS
IPR013122 PKD1_2_channel
IPR003915 PKD_2
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01825 GPS, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01433 POLYCYSTIN2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50221 GPS, 1 hit
PS50095 PLAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2EG98-1) [UniParc]FASTAAdd to basket
Also known as: Variant 1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLQRRSWLW LYIRIGVILG DILGRKPSIR EQHGGNSCYQ LNRLFCDFQE
60 70 80 90 100
ADNYCHAQRG RLAHTWNPKL RGFLKSFLNE ETVWWVRGNL TLPGSHPGIN
110 120 130 140 150
QTGGDDVLRN QKPGECPSVV THSNAVFSRW NLCIEKHHFI CQAAAFPPQG
160 170 180 190 200
ASIWRNEFGP GPLLPMKRRG AETERHMIPG NGPPLAMCHQ PAPPELFETL
210 220 230 240 250
CFPIDPASSA PPKATHRMTI TSLTGRPQVT SDTLASSSPP QGTSDTPASS
260 270 280 290 300
SPPQVTSATS ASSSPPQGTS DTPASSSPPQ VTSATSASSS PPQGTSDTPA
310 320 330 340 350
SSSPPQVTSA TSASSSPPQG TSDTPASSSP PQVTSATSAS SSPPQGTSDT
360 370 380 390 400
PASSSPPQGT LDTPSSSSPP QGTSDTPASS SPPQGTSETP ASNSPPQGTS
410 420 430 440 450
ETPGFSSPPQ VTTATLVSSS PPQVTSETPA SSSPTQVTSE TPASSSPTQV
460 470 480 490 500
TSDTPASNSP PQGTSDTPGF SSPTQVTTAT LVSSSPPQVT SDTPASSSPP
510 520 530 540 550
QVTSDTPASS SPPQVTSETP ASSSPPQVTS DTSASISPPQ VISDTPASSS
560 570 580 590 600
PPQVTSETPA SSSPTNMTSD TPASSSPTNM TSDTPASSSP TNMTSDTPAS
610 620 630 640 650
SSPPWPVITE VTRPESTIPA GRSLANITSK AQEDSPLGVI STHPQMSFQS
660 670 680 690 700
STSQALDETA GERVPTIPDF QAHSEFQKAC AILQRLRDFL PTSPTSAQKN
710 720 730 740 750
NSWSSQTPAV SCPFQPLGRL TTTEKSSHQM AQQDMEQHPM DGAHNAFGIS
760 770 780 790 800
AGGSEIQSDI QLRSEFEVED MLETSLMALG EIHRAFCQQS LCPQSAVTLA
810 820 830 840 850
SPSATLMLSS QNVSTLPLST YTLGEPAPLT LGFPSAEALK ELLNKHPGVN
860 870 880 890 900
LQVTGLAFNP FKTLDDKNIV GSIGNVQLSS AYQSIRVHDL IEDIEIMLWR
910 920 930 940 950
NASMETQPTS LNTSTDHFTI SVNITSLEKT LIVTIEPESP LLMTLHLGFQ
960 970 980 990 1000
DQLAHTHFYL NISLPRDQVW QKDEEYTWVL TPENLWYGTG TYYIMAVENK
1010 1020 1030 1040 1050
STEAAQHTPV LVSVVTAVTQ CYFWDRYNRT WKSDGCQVGP KSTILKTQCL
1060 1070 1080 1090 1100
CDHLTFFSSD FFIVPRTVDV ENTIKLLLHV TNNPVGVSLL SSLLGFYILL
1110 1120 1130 1140 1150
AMWASRKDRE DMQKVKVTVL ADNDPSSASH YLIQVYTGYR RRAATTAKVV
1160 1170 1180 1190 1200
ITLYGSEGHS EPHHLCDPEK TVFERGALDV FLLSTGSWLG DLHGLRLWHD
1210 1220 1230 1240 1250
NSGDSPSWYV SQVIVSDMTT RKKWHFQCNC WLAVDLGNCE RDRVFTPASR
1260 1270 1280 1290 1300
SELSSFRHLF SSTIVEKFTQ DYLWLSVATR HPWNQFTRVQ RLSCCMALLL
1310 1320 1330 1340 1350
CDMVINIMFW KMGGTTAKRG TEQLGPLAVT LSELLVSIQT SIILFPIHLI
1360 1370 1380 1390 1400
FGRLFQLIHP PEALPQLPFI QAAWPPALVC ESPSLTQVVK ELKETVGFLL
1410 1420 1430 1440 1450
RRNTQLLSEC EPSSCSSCDI NKLAKLLSGL IYCHLEDEGC HQQTESHWED
1460 1470 1480 1490 1500
AVSENHYHFC RYLLQLLRRL KAHLEALGAT QDHQSCDFSE AVSQLQNLQE
1510 1520 1530 1540 1550
LLETQTLRRG PGPCRHSTSF PILSPGEGKK PMSFCLFRWL KCSCWLLLGV
1560 1570 1580 1590 1600
ISLASAFFIT LYSLELDKDQ ATSWVISMML SVLQDIFISQ PIKVIFLTLL
1610 1620 1630 1640 1650
FSLMANHMPW LNKDKEQHAR RIVALWAKCP WSAPGLRDKN NPIYTAPAMN
1660 1670 1680 1690 1700
NLAKPTRKAW KKQLSKLTGG TLVQILFLTL LMTTVYSAKD SSRFFLHRAI
1710 1720 1730 1740 1750
WKRFSHRFSE IKTVEDFYPW ANGTLLPNLY GDYRGFITDG NSFLLGNVLI
1760 1770 1780 1790 1800
RQTRIPNDIF FPGSLHKQMK SPPQHQEDRE NYGAGWVPPD TNITKVDSIW
1810 1820 1830 1840 1850
HYQNQESLGG YPIQGELATY SGGGYVVRLG RNHSAATRVL QHLEQRRWLD
1860 1870 1880 1890 1900
HCTKALFVEF TVFNANVNLL CAVTLILESS GVGTFLTSLQ LDSLTSLQSS
1910 1920 1930 1940 1950
ERGFAWIVSQ VVYYLLVCYY AFIQGCRLKR QRLAFFTRKR NLLDTSIVLI
1960 1970 1980 1990 2000
SFSILGLSMQ SLSLLHKKMQ QYHCDRDRFI SFYEALRVNS AVTHLRGFLL
2010 2020 2030 2040 2050
LFATVRVWDL LRHHAQLQVI NKTLSKAWDE VLGFILIIVV LLSSYAMTFN
2060 2070 2080 2090 2100
LLFGWSISDY QSFFRSIVTV VGLLMGTSKH KEVIALYPIL GSLLVLSSII
2110 2120 2130 2140 2150
LMGLVIINLF VSAILIAFGK ERKACEKEAT LTDMLLQKLS SLLGIRLHQN
2160 2170 2180 2190 2200
PSEEHADNTG SSNLRERSSK SMSSDAEVLA PADAVGSVSG TDGNSGSTKV

L
Length:2,201
Mass (Da):241,253
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i389C31618FA84C07
GO
Isoform 2 (identifier: Q2EG98-2) [UniParc]FASTAAdd to basket
Also known as: Variant 1b

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: Q → QVSVANLLIDLSEQLLVLPFQ
     738-767: Missing.

Show »
Length:2,191
Mass (Da):240,263
Checksum:i9F312AD58E96BF0B
GO
Isoform 3 (identifier: Q2EG98-3) [UniParc]FASTAAdd to basket
Also known as: Variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     2200-2201: VL → GTRDI

Show »
Length:2,204
Mass (Da):241,584
Checksum:i83BDF05E0681618F
GO
Isoform 4 (identifier: Q2EG98-4) [UniParc]FASTAAdd to basket
Also known as: Variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     2200-2201: VL → IPASTVTKKCKQARHGGACL

Show »
Length:2,219
Mass (Da):243,092
Checksum:iCB7DBD597A8BB930
GO
Isoform 5 (identifier: Q2EG98-5) [UniParc]FASTAAdd to basket
Also known as: Variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     1885-2201: Missing.

Show »
Length:1,884
Mass (Da):205,802
Checksum:i82BCBEDE41DE70A2
GO
Isoform 6 (identifier: Q2EG98-6) [UniParc]FASTAAdd to basket
Also known as: Variant 5

The sequence of this isoform differs from the canonical sequence as follows:
     102-102: T → TDYIL
     698-698: Q → QVSVANLLIDLSEQLLVLPFQ
     738-767: Missing.
     1391-1409: ELKETVGFLLRRNTQLLSE → QCLKTITISAATFSNFCGD
     1410-2201: Missing.

Show »
Length:1,403
Mass (Da):151,051
Checksum:i3B20B74DC2F9CCE1
GO
Isoform 7 (identifier: Q2EG98-7) [UniParc]FASTAAdd to basket
Also known as: Variant 6

The sequence of this isoform differs from the canonical sequence as follows:
     1391-1398: ELKETVGF → VSLVSTVF
     1399-2201: Missing.

Show »
Length:1,398
Mass (Da):150,367
Checksum:i7D76E04DB329C85C
GO
Isoform 8 (identifier: Q2EG98-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: Q → QVSVANLLIDLSEQLLVLPFQ
     738-767: Missing.
     2161-2201: SSNLRERSSKSMSSDAEVLAPADAVGSVSGTDGNSGSTKVL → Y

Show »
Length:2,151
Mass (Da):236,389
Checksum:i138B68AC13771378
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLT9A0A1D5RLT9_MOUSE
Polycystic kidney disease protein 1...
Pkd1l3
816Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti294G → V in ABD36563 (PubMed:16805797).Curated1
Sequence conflicti308T → A in ABD36562 (PubMed:16805797).Curated1
Sequence conflicti308T → A in ABD36564 (PubMed:16805797).Curated1
Sequence conflicti794Q → L in ABD36564 (PubMed:16805797).Curated1
Sequence conflicti812N → K in ABD36564 (PubMed:16805797).Curated1
Sequence conflicti822T → P in ABD36564 (PubMed:16805797).Curated1
Sequence conflicti916D → G in ABD36564 (PubMed:16805797).Curated1
Sequence conflicti1063I → S in AAO32799 (PubMed:12782129).Curated1
Sequence conflicti1113Q → L in ABD36564 (PubMed:16805797).Curated1
Sequence conflicti1130H → L in ABD36564 (PubMed:16805797).Curated1
Sequence conflicti1341S → P in ABD36562 (PubMed:16805797).Curated1
Sequence conflicti1538R → K in ABD36562 (PubMed:16805797).Curated1
Sequence conflicti1618H → R in ABD36563 (PubMed:16805797).Curated1
Sequence conflicti1618H → R in ABD36566 (PubMed:16805797).Curated1
Sequence conflicti1618H → R in ABD36567 (PubMed:16805797).Curated1
Sequence conflicti1618H → R in ABD36568 (PubMed:16805797).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031952102T → TDYIL in isoform 6. 1 Publication1
Alternative sequenceiVSP_031953698Q → QVSVANLLIDLSEQLLVLPF Q in isoform 2, isoform 6 and isoform 8. 2 Publications1
Alternative sequenceiVSP_031954738 – 767Missing in isoform 2, isoform 6 and isoform 8. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_0319551391 – 1409ELKET…QLLSE → QCLKTITISAATFSNFCGD in isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0319561391 – 1398ELKETVGF → VSLVSTVF in isoform 7. 1 Publication8
Alternative sequenceiVSP_0319571399 – 2201Missing in isoform 7. 1 PublicationAdd BLAST803
Alternative sequenceiVSP_0319581410 – 2201Missing in isoform 6. 1 PublicationAdd BLAST792
Alternative sequenceiVSP_0319591885 – 2201Missing in isoform 5. 1 PublicationAdd BLAST317
Alternative sequenceiVSP_0319602161 – 2201SSNLR…STKVL → Y in isoform 8. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0319612200 – 2201VL → GTRDI in isoform 3. 1 Publication2
Alternative sequenceiVSP_0319622200 – 2201VL → IPASTVTKKCKQARHGGACL in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY164486 mRNA Translation: AAO32799.1
DQ382344 mRNA Translation: ABD36562.1
DQ382345 mRNA Translation: ABD36563.1
DQ382346 mRNA Translation: ABD36564.1
DQ382347 mRNA Translation: ABD36565.1
DQ382348 mRNA Translation: ABD36566.1
DQ382349 mRNA Translation: ABD36567.1
DQ382350 mRNA Translation: ABD36568.1
AC125162 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22654.1 [Q2EG98-8]
CCDS40472.1 [Q2EG98-1]
CCDS85608.1 [Q2EG98-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001034789.2, NM_001039700.2 [Q2EG98-1]
NP_001273383.1, NM_001286454.1 [Q2EG98-2]
NP_853522.2, NM_181544.2 [Q2EG98-8]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000057344; ENSMUSP00000051512; ENSMUSG00000048827 [Q2EG98-8]
ENSMUST00000109242; ENSMUSP00000104865; ENSMUSG00000048827 [Q2EG98-1]
ENSMUST00000212537; ENSMUSP00000148592; ENSMUSG00000048827 [Q2EG98-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
244646

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:244646

UCSC genome browser

More...
UCSCi
uc009niu.1 mouse [Q2EG98-1]
uc009niv.1 mouse [Q2EG98-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164486 mRNA Translation: AAO32799.1
DQ382344 mRNA Translation: ABD36562.1
DQ382345 mRNA Translation: ABD36563.1
DQ382346 mRNA Translation: ABD36564.1
DQ382347 mRNA Translation: ABD36565.1
DQ382348 mRNA Translation: ABD36566.1
DQ382349 mRNA Translation: ABD36567.1
DQ382350 mRNA Translation: ABD36568.1
AC125162 Genomic DNA No translation available.
CCDSiCCDS22654.1 [Q2EG98-8]
CCDS40472.1 [Q2EG98-1]
CCDS85608.1 [Q2EG98-2]
RefSeqiNP_001034789.2, NM_001039700.2 [Q2EG98-1]
NP_001273383.1, NM_001286454.1 [Q2EG98-2]
NP_853522.2, NM_181544.2 [Q2EG98-8]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi232669, 1 interactor
DIPiDIP-61249N
IntActiQ2EG98, 1 interactor
STRINGi10090.ENSMUSP00000104865

PTM databases

iPTMnetiQ2EG98
PhosphoSitePlusiQ2EG98

Proteomic databases

MaxQBiQ2EG98
PaxDbiQ2EG98
PRIDEiQ2EG98

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
72636 44 antibodies

Genome annotation databases

EnsembliENSMUST00000057344; ENSMUSP00000051512; ENSMUSG00000048827 [Q2EG98-8]
ENSMUST00000109242; ENSMUSP00000104865; ENSMUSG00000048827 [Q2EG98-1]
ENSMUST00000212537; ENSMUSP00000148592; ENSMUSG00000048827 [Q2EG98-2]
GeneIDi244646
KEGGimmu:244646
UCSCiuc009niu.1 mouse [Q2EG98-1]
uc009niv.1 mouse [Q2EG98-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
342372
MGIiMGI:2664670 Pkd1l3

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410YE1E LUCA
GeneTreeiENSGT00940000162813
HOGENOMiCLU_000913_1_0_1
InParanoidiQ2EG98
KOiK04989
OrthoDBi1276906at2759
TreeFamiTF316484

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pkd1l3 mouse

Protein Ontology

More...
PROi
PR:Q2EG98
RNActiQ2EG98 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048827 Expressed in vallate papilla and 19 other tissues
ExpressionAtlasiQ2EG98 baseline and differential

Family and domain databases

CDDicd01752 PLAT_polycystin, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000203 GPS
IPR013122 PKD1_2_channel
IPR003915 PKD_2
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
PfamiView protein in Pfam
PF01825 GPS, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR01433 POLYCYSTIN2
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50221 GPS, 1 hit
PS50095 PLAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK1L3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2EG98
Secondary accession number(s): E9QPA5
, Q2EG93, Q2EG94, Q2EG95, Q2EG96, Q2EG97, Q2EG99, Q7TN87
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: April 22, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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