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Protein

Taste receptor type 2 member 40

Gene

TAS2R40

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bitter taste receptor (PubMed:25796330). Binds quinine, dextromethorphan, diphenhydramine, diphenidol, chlorpheniramine, diphenidol, chloramphenicol, chloroquine and coumarin, this latter being a weak agonist, as well as epiquinidine, ethylhydrocupreine and quinidine (PubMed:28811548).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-418594 G alpha (i) signalling events
R-GGA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Taste receptor type 2 member 40
Short name:
T2R40
Alternative name(s):
Taste receptor type 2 member 1
Short name:
T2R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAS2R40
Synonyms:TAS2R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9ExtracellularCurated9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 55CytoplasmicCuratedAdd BLAST25
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 87ExtracellularCuratedAdd BLAST11
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 128CytoplasmicCuratedAdd BLAST20
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 178ExtracellularCuratedAdd BLAST29
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 235CytoplasmicCuratedAdd BLAST36
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 266ExtracellularCurated10
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 311CytoplasmicCuratedAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86K → A: No effect on quinine-, nor diphenhydramine-binding, small decrease in diphenidol- and chlorpheniramine-binding, strong decrease in chloramphenicol- and chloroquine-binding, increase in coumarin-binding. 1 Publication1
Mutagenesisi89F → A: Strong increase in quinine-binding, loss of diphenhydramine- and coumarin-binding, small decrease in diphenidol-binding, strong decrease in chlorpheniramine-, chloramphenicol- and chloroquine-binding. 1 Publication1
Mutagenesisi93N → A: Loss of quinine-, diphenhydramine- and coumarin-binding, strong decrease in diphenidol-, chlorpheniramine-, chloramphenicol- and chloroquine-binding. 1 Publication1
Mutagenesisi181F → A: Loss of quinine-, diphenhydramine- and coumarin-binding, strong decrease in diphenidol-, chloramphenicol- and chloroquine-binding, decrease in chlorpheniramine-binding. 1 Publication1
Mutagenesisi185L → A: Strong decrease in quinine- and diphenhydramine-binding, no effect on diphenidol-, nor chlorpheniramine-binding, small decrease in chloramphenicol- and chloroquine-binding, loss of coumarin-binding. 1 Publication1
Mutagenesisi244Y → A: Loss of quinine- and diphenhydramine-binding, strong decrease in diphenidol-binding, small decrease in chloramphenicol-binding, increase in coumarin-binding, no effect on chlorpheniramine-, nor chloramphenicol-binding. 1 Publication1
Mutagenesisi247N → A: Loss of quinine-, diphenhydramine- and coumarin-binding, strong decrease in diphenidol-binding, small decrease in chlorpheniramine- and chloramphenicol-binding, no effect on chloramphenicol-binding. 1 Publication1
Mutagenesisi251L → A: Strong decrease in quinine-binding, loss of diphenhydramine-binding, small decrease in diphenidol- and chloramphenicol-binding, no effect on chlorpheniramine-, chloramphenicol-, nor coumarin-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_50101369051 – 311Taste receptor type 2 member 40Add BLAST311

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the oral cavity, as well as in the gastrointestinal tract, including in the upper palate, tongue, proventriculus, ventriculus, duodenum, jejunum, ileum, cecum and colon.2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q2AB83

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor T2R family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP9I Eukaryota
ENOG410YMY3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234595

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG060698

KEGG Orthology (KO)

More...
KOi
K08474

Database of Orthologous Groups

More...
OrthoDBi
1010573at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2AB83

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007960 T2R

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05296 TAS2R, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2AB83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLFSSFCL VIAIFESVVG LLGNGTIVAV SSTSCIRSKI LSSYDVIVIF
60 70 80 90 100
LSLSRFFLQL WMILDFLLIF FCQPSYYEEN LFVTFKTVFI FLNSYSFWFA
110 120 130 140 150
AWLSVFYCVK VASFTQSFLS WLKQRIASLI PWMLITSSLF SFATSLPFFW
160 170 180 190 200
DSYNAHSNFT TPLTMTNSSK RITTRKTNLI FLILLCNVGI ALPSIMLVFS
210 220 230 240 250
SILLIRSLWR HTRQMQNNAT GFRDPSLEAL IGAIKTVFSF LLLYITNFIA
260 270 280 290 300
LILILSDTFV PLSTEEAICV VVVAACPAGQ SMVLIWSNPR FRELLSSILH
310
YVNSCVRARC S
Length:311
Mass (Da):35,281
Last modified:April 4, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBFFA294F498C093
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120S → T in AMA21693 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21695 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21696 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21697 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21702 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21704 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21706 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21708 (Ref. 3) Curated1
Sequence conflicti120S → T in AMA21709 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB249766 Genomic DNA Translation: BAE80384.1
AADN04000390 Genomic DNA No translation available.
KT377136 Genomic DNA Translation: AMA21693.1
KT377152 Genomic DNA Translation: AMA21709.1
KT377138 Genomic DNA Translation: AMA21695.1
KT377139 Genomic DNA Translation: AMA21696.1
KT377140 Genomic DNA Translation: AMA21697.1
KT377145 Genomic DNA Translation: AMA21702.1
KT377147 Genomic DNA Translation: AMA21704.1
KT377149 Genomic DNA Translation: AMA21706.1
KT377151 Genomic DNA Translation: AMA21708.1

NCBI Reference Sequences

More...
RefSeqi
XP_004938201.1, XM_004938144.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000081605; ENSGALP00000051324; ENSGALG00000030506

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101749182

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:101749182

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB249766 Genomic DNA Translation: BAE80384.1
AADN04000390 Genomic DNA No translation available.
KT377136 Genomic DNA Translation: AMA21693.1
KT377152 Genomic DNA Translation: AMA21709.1
KT377138 Genomic DNA Translation: AMA21695.1
KT377139 Genomic DNA Translation: AMA21696.1
KT377140 Genomic DNA Translation: AMA21697.1
KT377145 Genomic DNA Translation: AMA21702.1
KT377147 Genomic DNA Translation: AMA21704.1
KT377149 Genomic DNA Translation: AMA21706.1
KT377151 Genomic DNA Translation: AMA21708.1
RefSeqiXP_004938201.1, XM_004938144.2

3D structure databases

ProteinModelPortaliQ2AB83
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000081605; ENSGALP00000051324; ENSGALG00000030506
GeneIDi101749182
KEGGigga:101749182

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
259286

Phylogenomic databases

eggNOGiENOG410IP9I Eukaryota
ENOG410YMY3 LUCA
GeneTreeiENSGT00940000153065
HOGENOMiHOG000234595
HOVERGENiHBG060698
KOiK08474
OrthoDBi1010573at2759
PhylomeDBiQ2AB83

Enzyme and pathway databases

ReactomeiR-GGA-418594 G alpha (i) signalling events
R-GGA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q2AB83

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT2R40_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2AB83
Secondary accession number(s): A0A0X9UE61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2017
Last sequence update: April 4, 2006
Last modified: January 16, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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