Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium-dependent neutral amino acid transporter B(0)AT1

Gene

Slc6a19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent.By similarity

GO - Molecular functioni

GO - Biological processi

  • response to nutrient Source: RGD

Keywordsi

Biological processAmino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230 Amino acid transport across the plasma membrane
R-RNO-442660 Na+/Cl- dependent neurotransmitter transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT1
Alternative name(s):
Solute carrier family 6 member 19
System B(0) neutral amino acid transporter AT1
Gene namesi
Name:Slc6a19Imported
Synonyms:B0at1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1594328 Slc6a19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 65ExtracellularSequence analysis3
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 119CytoplasmicSequence analysisAdd BLAST33
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 192ExtracellularSequence analysisAdd BLAST52
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 221CytoplasmicSequence analysis8
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 268ExtracellularSequence analysisAdd BLAST26
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 304CytoplasmicSequence analysisAdd BLAST15
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 413ExtracellularSequence analysisAdd BLAST88
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 456CytoplasmicSequence analysisAdd BLAST22
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 490ExtracellularSequence analysisAdd BLAST13
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 531CytoplasmicSequence analysisAdd BLAST20
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 581ExtracellularSequence analysisAdd BLAST29
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 634CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994981 – 634Sodium-dependent neutral amino acid transporter B(0)AT1Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei627PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2A865
PRIDEiQ2A865

PTM databases

iPTMnetiQ2A865
PhosphoSitePlusiQ2A865

Expressioni

Inductioni

By high salt intake in SHR rats. Reduced level upon high salt intake in Wistar Kyoto rats.1 Publication

Gene expression databases

BgeeiENSRNOG00000026501 Expressed in 3 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ2A865 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028917

Structurei

3D structure databases

ProteinModelPortaliQ2A865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000119044
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ2A865
KOiK05334
OMAiGYVEECA
OrthoDBiEOG091G08PX
PhylomeDBiQ2A865
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002438 Na/ntran_symport_orphan
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01206 ORPHTRNSPORT
SUPFAMiSSF161070 SSF161070, 2 hits
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2A865-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRLVLPNPG LEDRIPSLDE LEVIEKEEAS SRPKWDNKAQ YMLTCVGFCV
60 70 80 90 100
GLGNVWRFPY LCQSHGGGAF MIPFLILLVL EGIPLLHLEF AIGQRLRKGS
110 120 130 140 150
VGVWSSIHPA LKGVGIASMF VSFMVGLYYN TIIAWVMWYF FNSFQEPLPW
160 170 180 190 200
SECPLNQNQT GYVEECAKSS SVDYFWYRET LNISTSISDS GSIQWWILLC
210 220 230 240 250
LTCAWSVLYV CTIRGIETTG KAVYITSTLP YVVLTIFLIR GLTLKGATNG
260 270 280 290 300
IVFLFTPNIT ELSNPNTWLD AGAQVFYSFS LAFGGLISFS SYNSVHNNCE
310 320 330 340 350
MDSVIVSIIN GFTSVYAATV VYSIIGFRAT ERFDDCVNTN ILTLINGFDL
360 370 380 390 400
PEGNVTAENF EAYQHWCNAT NPEAYAQLTF QTCDINTFLS EGVEGTGLAF
410 420 430 440 450
IVFTEAITKM PVSPLWSVLF FIMLFCLGLS SMFGNMEGVV VPLQDLNITP
460 470 480 490 500
KKWPKELLTG LICLGTYLIA FIFTLNSGQY WLSLLDSYAG SIPLLIIAFC
510 520 530 540 550
EMFAVVYVYG VDRFNKDIEF MIGHKPNIFW QVTWRVVSPL IMLVIFLFFF
560 570 580 590 600
VIEVNKQLMY SVWDPDYEEF PKSQKVPYPD WVYAVVVIVA GVPCLTIPCF
610 620 630
AIYKLIRNYC QKSGDQHGLV NALSTASVNG DLKN
Length:634
Mass (Da):71,232
Last modified:September 11, 2007 - v2
Checksum:i005015BEAF876CE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32R → K in CAI64591 (Ref. 1) Curated1
Sequence conflicti186S → P in CAI64591 (Ref. 1) Curated1
Sequence conflicti276F → Y in CAI64591 (Ref. 1) Curated1
Sequence conflicti433F → L in ABP63542 (PubMed:17646927).Curated1
Sequence conflicti458L → F in ABP63542 (PubMed:17646927).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890206 mRNA Translation: CAI64591.1
EF474455 mRNA Translation: ABP63542.1
RefSeqiNP_001034811.1, NM_001039722.2
UniGeneiRn.213283

Genome annotation databases

EnsembliENSRNOT00000036714; ENSRNOP00000028917; ENSRNOG00000026501
GeneIDi664630
KEGGirno:664630
UCSCiRGD:1594328 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890206 mRNA Translation: CAI64591.1
EF474455 mRNA Translation: ABP63542.1
RefSeqiNP_001034811.1, NM_001039722.2
UniGeneiRn.213283

3D structure databases

ProteinModelPortaliQ2A865
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028917

Chemistry databases

GuidetoPHARMACOLOGYi939

PTM databases

iPTMnetiQ2A865
PhosphoSitePlusiQ2A865

Proteomic databases

PaxDbiQ2A865
PRIDEiQ2A865

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036714; ENSRNOP00000028917; ENSRNOG00000026501
GeneIDi664630
KEGGirno:664630
UCSCiRGD:1594328 rat

Organism-specific databases

CTDi340024
RGDi1594328 Slc6a19

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000119044
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ2A865
KOiK05334
OMAiGYVEECA
OrthoDBiEOG091G08PX
PhylomeDBiQ2A865
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-RNO-352230 Amino acid transport across the plasma membrane
R-RNO-442660 Na+/Cl- dependent neurotransmitter transporters

Miscellaneous databases

PROiPR:Q2A865

Gene expression databases

BgeeiENSRNOG00000026501 Expressed in 3 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ2A865 RN

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002438 Na/ntran_symport_orphan
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01206 ORPHTRNSPORT
SUPFAMiSSF161070 SSF161070, 2 hits
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS6A19_RAT
AccessioniPrimary (citable) accession number: Q2A865
Secondary accession number(s): A4ZVM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 12, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again