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Protein
Submitted name:

Polyprotein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 136Peptidase A2InterPro annotationAdd BLAST70
Domaini190 – 380Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit

Sequencei

Sequence statusi: Fragment.

Q2A7P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AFPQGEAGEF SSEQTRANSP TSRELRVWGR NNPLSETGAE GQGSLSFPQI
60 70 80 90 100
TLWQRPLVSI KVGGQIKEAL LDTGADDTVL EEINLPGKWK PKMIGGIGGF
110 120 130 140 150
IKVRQYDQVP IEICGYKAIG TVLVGPTPVN IIGRNLLTQI GCTLNFPISP
160 170 180 190 200
IETVPVKLKP GMDGPKVKQW PLTEEKIKAL VEICTEMEKE GKISRIGPEN
210 220 230 240 250
PYNTPIFAIK KKDSTKWRKL VDFRELNKRT QDFWEVQLGI PHPAGLKKKK
260 270 280 290 300
SVTVLDVGDA YFSVPLDESF RKYTAFTIPS INNETPGIRY QYNVLPQGWK
310 320 330 340 350
GSPAIFQSSM IKILEPFKKQ NPELVIYQYM DDLYVGSDLE IGQHRTKIEK
360 370 380 390 400
LREHLLRWGL TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI TLPEKESWTV
410 420 430 440 450
NDIQKLVGKL NWASQIYPGI KIKQLCKLLR GAKALTEVIP LTAEAELELA
460 470 480 490 500
ENREILKNPV HGVYYDPSKD LIAEVQKQGE GQWTYQIYQE PFKNLKTGKY
510 520 530 540 550
ARMRGAHTND IKQLTEAVQK IATESIVIWG KTPKFRLPIQ KETWEAWWRE
560 570 580
YWQATWIPEW EFVNTPPLVK LWYQLEKEPI IGAET
Length:585
Mass (Da):66,879
Last modified:April 4, 2006 - v1
Checksum:i20AFF574ED3A33DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei585Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM041003 Genomic DNA Translation: CAJ13897.1

Similar proteinsi

Entry informationi

Entry nameiQ2A7P4_9HIV1
AccessioniPrimary (citable) accession number: Q2A7P4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 18, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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