UniProtKB - Q29RX4 (Q29RX4_HUMAN)
Protein
Band 4.1
Gene
EPB41
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- structural molecule activity Source: InterPro
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cortical actin cytoskeleton organization Source: InterPro
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation |
Biological process | Cell cycle, Cell division, MitosisARBA annotation, TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Band 4.1ARBA annotationAlternative name(s): Erythrocyte membrane protein band 4.1ARBA annotation Protein 4.1ARBA annotation |
Gene namesi | Name:EPB41Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Other locations
- cell cortex ARBA annotation
Cytoskeleton
- cytoskeleton Source: InterPro
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | Q29RX4 |
PRIDEi | Q29RX4 |
Interactioni
GO - Molecular functioni
- actin binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 402 | FERMInterPro annotationAdd BLAST | 282 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 113 | DisorderedSequence analysisAdd BLAST | 113 | |
Regioni | 429 – 526 | DisorderedSequence analysisAdd BLAST | 98 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 528 – 548 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 33 | PolyampholyteSequence analysisAdd BLAST | 33 | |
Compositional biasi | 69 – 113 | PolyampholyteSequence analysisAdd BLAST | 45 | |
Compositional biasi | 497 – 526 | PolyampholyteSequence analysisAdd BLAST | 30 |
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q29RX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
PKSQVSEEEG KEVESDKEKG EGGQKEIEFG TSLDEEIILK APIAAPEPEL
60 70 80 90 100
KTDPSLDLHS LSSAETQPAQ EELREDPDFE IKEGEGLEEC SKIEVKEESP
110 120 130 140 150
QSKAETELKA SQKPIRKHRN MHCKVSLLDD TVYECVVEKH AKGQDLLKRV
160 170 180 190 200
CEHLNLLEED YFGLAIWDNA TSKTWLDSAK EIKKQVRGVP WNFTFNVKFY
210 220 230 240 250
PPDPAQLTED ITRYYLCLQL RQDIVAGRLP CSFATLALLG SYTIQSELGD
260 270 280 290 300
YDPELHGVDY VSDFKLAPNQ TKELEEKVME LHKSYRSMTP AQADLEFLEN
310 320 330 340 350
AKKLSMYGVD LHKAKDLEGV DIILGVCSSG LLVYKDKLRI NRFPWPKVLK
360 370 380 390 400
ISYKRSSFFI KIRPGEQEQY ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL
410 420 430 440 450
TSTDTIPKSK FLALGSKFRY SGRTQAQTRQ ASALIDRPAP HFERTASKRA
460 470 480 490 500
SRSLDGAAAV DSADRSPRPT SAPAITQGQV AEGGVLDASA KKTVVPKAQK
510 520 530 540 550
ETVKAEVKKE DEPPEQAEPE PTEAWKDLDK SQEEIKKHHA SISELKKNFM
560 570 580 590 600
ESVPEPRPSE WDKRLSTHSP FRTLNINGQI PTGEGTDDNS GDLDPGVLLT
610 620 630 640 650
AQTITSETPS STTTTQITKT VKGGISETRI EKRIVITGDA DIDHDQVLVQ
660 670
AIKEAKEQHP DMSVTKVVVH QETEIADE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC113841 mRNA Translation: AAI13842.1 |
RefSeqi | NP_001159479.1, NM_001166007.1 |
Genome annotation databases
GeneIDi | 2035 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC113841 mRNA Translation: AAI13842.1 |
RefSeqi | NP_001159479.1, NM_001166007.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q29RX4 |
PRIDEi | Q29RX4 |
Protocols and materials databases
DNASUi | 2035 |
Genome annotation databases
GeneIDi | 2035 |
Organism-specific databases
CTDi | 2035 |
PharmGKBi | PA27810 |
Miscellaneous databases
BioGRID-ORCSi | 2035, 9 hits in 850 CRISPR screens |
ChiTaRSi | EPB41, human |
GenomeRNAii | 2035 |
Gene expression databases
Genevisiblei | Q29RX4, HS |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q29RX4_HUMAN | |
Accessioni | Q29RX4Primary (citable) accession number: Q29RX4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 4, 2006 |
Last sequence update: | April 4, 2006 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |