Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat-containing protein 41

Gene

LRRC41

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 41
Gene namesi
Name:LRRC41
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926571 – 814Leucine-rich repeat-containing protein 41Add BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei327PhosphothreonineBy similarity1
Modified residuei375PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ29RR1
PRIDEiQ29RR1

Interactioni

Subunit structurei

Part of a E3 ubiquitin ligase complex with elongin BC complex (ELOB and ELOC), RBX1 and CUL5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040694

Structurei

3D structure databases

ProteinModelPortaliQ29RR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati489 – 509LRR 1Add BLAST21
Repeati520 – 532LRR 2Add BLAST13
Repeati533 – 557LRR 3Add BLAST25
Repeati615 – 637LRR 4Add BLAST23
Repeati638 – 661LRR 5Add BLAST24
Repeati703 – 730LRR 6Add BLAST28
Repeati733 – 754LRR 7Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 54Interaction with Elongin BC complexBy similarity10

Domaini

The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x3-C-x3-[AILV].By similarity

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHRR Eukaryota
ENOG410YFW5 LUCA
HOGENOMiHOG000013094
HOVERGENiHBG102701
InParanoidiQ29RR1
KOiK10347

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026137 Leu_rpt_41
IPR032675 LRR_dom_sf
PANTHERiPTHR15354 PTHR15354, 1 hit

Sequencei

Sequence statusi: Complete.

Q29RR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP SAPPALFELC
60 70 80 90 100
GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ
110 120 130 140 150
AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDRRLC
160 170 180 190 200
DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF
210 220 230 240 250
RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS
260 270 280 290 300
AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
310 320 330 340 350
LMASRRKSEA KQTARAAPAT RVTRRSTQES LTAGGTDSKR EPLPPATSHE
360 370 380 390 400
APGTKRPPSA PATTSSASAS SSTSSSKRAP ASSAPQPKPL KRFKRAAGKK
410 420 430 440 450
GARTRQGCGA ESEDLYDFVF IVAGEKEDGE EMEIGEVACG ALDGSDPSCL
460 470 480 490 500
GLPALEASQR FRSISTLELF TVPLSTEAAL TLCHLLSSWV SLESLTLSYN
510 520 530 540 550
GLGSNIFRLL DSLRALSVQA GCRLRALHLS DLFSPLPILE LTRAIVRALP
560 570 580 590 600
LLRVLSIRVD HPSQRDNPAV PGNAGPPSNV IGDEEIPENC LEQLEMGFPR
610 620 630 640 650
GAQPAPLLCS VLKASGSLQQ LSLDSATFAS PQDFGLVLQT LKEYNLTLKR
660 670 680 690 700
LSFHDMNLAD CQSEVLFLLQ NLTLQEITFS FCRLFEKRPA QFLPEMVAAM
710 720 730 740 750
KGNSTLKGLR LPGNRLGNAG LLALADVFSE DSSSSLCQLD ISSNCIKPDG
760 770 780 790 800
LLEFAKRLER WGRGAFGHLR LFQNWLDQDA VTAREAIRRL RATCHVVSDS
810
WDSSQAFADY VSTM
Length:814
Mass (Da):88,677
Last modified:April 4, 2006 - v1
Checksum:i60608574DFB79A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114065 mRNA Translation: AAI14066.1
RefSeqiNP_001039338.1, NM_001045873.1
UniGeneiBt.37162

Genome annotation databases

GeneIDi337889
KEGGibta:337889

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114065 mRNA Translation: AAI14066.1
RefSeqiNP_001039338.1, NM_001045873.1
UniGeneiBt.37162

3D structure databases

ProteinModelPortaliQ29RR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040694

Proteomic databases

PaxDbiQ29RR1
PRIDEiQ29RR1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi337889
KEGGibta:337889

Organism-specific databases

CTDi10489

Phylogenomic databases

eggNOGiENOG410IHRR Eukaryota
ENOG410YFW5 LUCA
HOGENOMiHOG000013094
HOVERGENiHBG102701
InParanoidiQ29RR1
KOiK10347

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026137 Leu_rpt_41
IPR032675 LRR_dom_sf
PANTHERiPTHR15354 PTHR15354, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLRC41_BOVIN
AccessioniPrimary (citable) accession number: Q29RR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again