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Protein

Suppressor of cytokine signaling 5

Gene

SOCS5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 5
Short name:
SOCS-5
Gene namesi
Name:SOCS5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443821 – 536Suppressor of cytokine signaling 5Add BLAST536

Post-translational modificationi

Phosphorylated. Phosphorylation is induced by EGF (By similarity).By similarity

Proteomic databases

PaxDbiQ29RN6
PRIDEiQ29RN6

Interactioni

Subunit structurei

Interacts with EGFR. Interacts with ELOB and ELOC; mediates EGFR ubiquitination and degradation. Interacts with IL4R; inhibits IL4 signaling (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011826

Structurei

3D structure databases

ProteinModelPortaliQ29RN6
SMRiQ29RN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini381 – 476SH2PROSITE-ProRule annotationAdd BLAST96
Domaini471 – 520SOCS boxPROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Required for interaction with IL4RBy similarityAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiQ29RN6
KOiK04698

Family and domain databases

CDDicd03739 SOCS_SOCS5, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR028420 SOCS5
IPR037343 SOCS5_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF3 PTHR44282:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q29RN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KKKNISLGDS
60 70 80 90 100
APQQQSSPLR ENVALQLGLS PSKNSSRRNQ NCAAEIPQIV EISIEKDNDS
110 120 130 140 150
CVTPGTRLAR RDSYSRHAPW GGKKKHSCST KTQSSLDTDK KFGRTRSGLQ
160 170 180 190 200
RRERRYGVSS VHDMDSVSSR TVGSRSLRQR LQDTVGLCFP MRTYSKQSKP
210 220 230 240 250
LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV SPHSTFFDTF
260 270 280 290 300
DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
310 320 330 340 350
PKLAPGMTEV NGDSCAVPQA NCDSEEDTTT LCLQSRRQKQ RQVSGDSHAH
360 370 380 390 400
VSRQGAWKVH TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE
410 420 430 440 450
GTFLLRDSAQ EDYLFSVSFR RYNRSLHARI EQWNHNFSFD AHDPCVFHSS
460 470 480 490 500
TVTGLLEHYK DPSSCMFFEP LLTISLNRTF PFSLQYICRA VICRCTTYDG
510 520 530
IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK
Length:536
Mass (Da):61,172
Last modified:April 4, 2006 - v1
Checksum:i64AEAFB80EE6BB71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114096 mRNA Translation: AAI14097.1
RefSeqiNP_001039647.1, NM_001046182.1
UniGeneiBt.58314

Genome annotation databases

GeneIDi514773
KEGGibta:514773

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114096 mRNA Translation: AAI14097.1
RefSeqiNP_001039647.1, NM_001046182.1
UniGeneiBt.58314

3D structure databases

ProteinModelPortaliQ29RN6
SMRiQ29RN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011826

Proteomic databases

PaxDbiQ29RN6
PRIDEiQ29RN6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514773
KEGGibta:514773

Organism-specific databases

CTDi9655

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiQ29RN6
KOiK04698

Enzyme and pathway databases

UniPathwayi
UPA00143

Family and domain databases

CDDicd03739 SOCS_SOCS5, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR028420 SOCS5
IPR037343 SOCS5_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF3 PTHR44282:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS5_BOVIN
AccessioniPrimary (citable) accession number: Q29RN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: November 7, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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