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Entry version 95 (23 Feb 2022)
Sequence version 1 (04 Apr 2006)
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Protein

Zinc finger protein 574

Gene

ZNF574

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri76 – 98C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri126 – 148C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri466 – 489C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri495 – 517C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 630C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri636 – 659C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri667 – 689C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri822 – 844C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 574
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF574
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSBTAG00000021789

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:50117, ZNF574

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002748601 – 896Zinc finger protein 574Add BLAST896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei164PhosphoserineBy similarity1
Modified residuei298PhosphoserineBy similarity1
Modified residuei717PhosphoserineBy similarity1
Modified residuei832Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q29RK0

PRoteomics IDEntifications database

More...
PRIDEi
Q29RK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q29RK0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000047002

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q29RK0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni259 – 303DisorderedSequence analysisAdd BLAST45
Regioni434 – 460DisorderedSequence analysisAdd BLAST27
Regioni687 – 733DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi279 – 296Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri76 – 98C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri126 – 148C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri466 – 489C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri495 – 517C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 630C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri636 – 659C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri667 – 689C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri822 – 844C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161799

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q29RK0

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQRFECG

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q29RK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLMHQNSHVP QQHFELVGVA
60 70 80 90 100
DPGVTVAAEA ASGTGLYQTL VQESQYQCLE CGQLLMSPSQ LLEHQELHLK
110 120 130 140 150
MMAPQEAVPA EPPPKAPALS SSTIHYECVD CKALFASQEL WLNHRQTHLR
160 170 180 190 200
ATPTKPPTPV VLGSPVVVGS PVGQTRVAVE HSYRKAEEGG EGAAVPSAAA
210 220 230 240 250
TTTEVVTEVE LLLYKCSECS QLFQLPADFL EHQATHFPAP APESEEPVLQ
260 270 280 290 300
QETLTPAPVE VPVSQPEPVP SSDHSYELRN GEALGRDRRG RRARRNNSGE
310 320 330 340 350
PGGAATQELF CSACDQLFLS PHQLQQHLRS HREGVFKCPL CSRVFPSPSS
360 370 380 390 400
LDQHLGDHSS ESHFLCVDCG LAFGTEALLL AHRRAHTPNP LHSCPCGKTF
410 420 430 440 450
VNLTKFLYHR RTHGVGGVPL PTTPVPPEEP VLGFPEPAPA ETGEPEAPEP
460 470 480 490 500
PVAEESSAEP AAPGTYRCLL CSREFGKALQ LTRHQRFVHR LERRHKCSIC
510 520 530 540 550
GKMFKKKSHV RNHLRTHTGE RPFPCPDCSK PFNSPANLAR HRLTHTGERP
560 570 580 590 600
YRCGDCGKAF TQSSTLRQHR LVHAQHFPYR CQECGVRFHR PYRLLMHRYH
610 620 630 640 650
HTGEYPYKCR ECPRSFLLRR LLEVHQLVAH AGRQPHRCSS CGAAFPSSLR
660 670 680 690 700
LREHRCAAAA AQAPRRFECG TCGKKVGSAA RLQAHEAAHA AAGPGEVLAK
710 720 730 740 750
EPPAPRAPRA ARTPITSPTT LGSAAPAAPA APARRRGLEC SECKKLFSTE
760 770 780 790 800
TSLQVHRRIH TGERPYPCPD CGKAFRQSTH LKDHRRLHTG ERPFACEVCG
810 820 830 840 850
KAFAISMRLA EHRRIHTGER PYSCPDCGKS YRSFSNLWKH RKTHQQQHQA
860 870 880 890
AVRQQLAEAE AAVGLAVMET AVEALPLVEA IEIYPLAEAE GVQISG
Length:896
Mass (Da):99,010
Last modified:April 4, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i638621A80D398E78
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC114139 mRNA Translation: AAI14140.1

NCBI Reference Sequences

More...
RefSeqi
NP_001070007.1, NM_001076539.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000031986; ENSBTAP00000047002; ENSBTAG00000021789

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
767618

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:767618

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114139 mRNA Translation: AAI14140.1
RefSeqiNP_001070007.1, NM_001076539.1

3D structure databases

SMRiQ29RK0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047002

Proteomic databases

PaxDbiQ29RK0
PRIDEiQ29RK0

Genome annotation databases

EnsembliENSBTAT00000031986; ENSBTAP00000047002; ENSBTAG00000021789
GeneIDi767618
KEGGibta:767618

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64763
VEuPathDBiHostDB:ENSBTAG00000021789
VGNCiVGNC:50117, ZNF574

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161799
InParanoidiQ29RK0
OMAiPQRFECG
OrthoDBi1318335at2759

Gene expression databases

ExpressionAtlasiQ29RK0, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 20 hits
SUPFAMiSSF57667, SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 19 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN574_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q29RK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 4, 2006
Last modified: February 23, 2022
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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