Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (18 Sep 2019)
Sequence version 1 (04 Apr 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

PDS5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.2 Publications

Miscellaneous

HeLa cells with a reduced level of PDS5A show a mild defect in sister chromatid cohesion. HeLa cells with a reduced level of RAD21 show reduced association of PDS5A with chromatin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2468052 Establishment of Sister Chromatid Cohesion
R-HSA-2470946 Cohesin Loading onto Chromatin
R-HSA-2500257 Resolution of Sister Chromatid Cohesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
Alternative name(s):
Cell proliferation-inducing gene 54 protein
Sister chromatid cohesion protein 112
Short name:
SCC-112
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDS5AImported
Synonyms:KIAA0648Imported, PDS51 Publication
ORF Names:PIG54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29088 PDS5A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613200 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q29RF7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23244

Open Targets

More...
OpenTargetsi
ENSG00000121892

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399027

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDS5A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121947590

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002963411 – 1337Sister chromatid cohesion protein PDS5 homolog AAdd BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei1097PhosphoserineCombined sources1
Modified residuei1146N6-acetyllysineCombined sources1
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1208PhosphothreonineCombined sources1
Modified residuei1211N6-acetyllysineCombined sources1
Modified residuei1290N6-acetyllysineCombined sources1
Modified residuei1305PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q29RF7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q29RF7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q29RF7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q29RF7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q29RF7

PeptideAtlas

More...
PeptideAtlasi
Q29RF7

PRoteomics IDEntifications database

More...
PRIDEi
Q29RF7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61286 [Q29RF7-1]
61287 [Q29RF7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q29RF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q29RF7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q29RF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Cell cycle-regulated with highest level in G2 phase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121892 Expressed in 238 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q29RF7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q29RF7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036661
HPA036662

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cohesin complex.

Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive.

Interacts with SMC3.

Interacts with TP63.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116848, 93 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q29RF7

Database of interacting proteins

More...
DIPi
DIP-35419N

Protein interaction database and analysis system

More...
IntActi
Q29RF7, 62 interactors

Molecular INTeraction database

More...
MINTi
Q29RF7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000303427

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q29RF7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati393 – 429HEATSequence analysisAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1525 Eukaryota
ENOG410XQW7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155155

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230672

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q29RF7

KEGG Orthology (KO)

More...
KOi
K11267

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIEPCIA

Database of Orthologous Groups

More...
OrthoDBi
69768at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q29RF7

TreeFam database of animal gene trees

More...
TreeFami
TF106415

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039776 Pds5

The PANTHER Classification System

More...
PANTHERi
PTHR12663 PTHR12663, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q29RF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFTAQPKPA TALCGVVSAD GKIAYPPGVK EITDKITTDE MIKRLKMVVK
60 70 80 90 100
TFMDMDQDSE DEKQQYLPLA LHLASEFFLR NPNKDVRLLV ACCLADIFRI
110 120 130 140 150
YAPEAPYTSH DKLKDIFLFI TRQLKGLEDT KSPQFNRYFY LLENLAWVKS
160 170 180 190 200
YNICFELEDC NEIFIQLFRT LFSVINNSHN KKVQMHMLDL MSSIIMEGDG
210 220 230 240 250
VTQELLDSIL INLIPAHKNL NKQSFDLAKV LLKRTVQTIE ACIANFFNQV
260 270 280 290 300
LVLGRSSVSD LSEHVFDLIQ ELFAIDPHLL LSVMPQLEFK LKSNDGEERL
310 320 330 340 350
AVVRLLAKLF GSKDSDLATQ NRPLWQCFLG RFNDIHVPVR LESVKFASHC
360 370 380 390 400
LMNHPDLAKD LTEYLKVRSH DPEEAIRHDV IVTIITAAKR DLALVNDQLL
410 420 430 440 450
GFVRERTLDK RWRVRKEAMM GLAQLYKKYC LHGEAGKEAA EKVSWIKDKL
460 470 480 490 500
LHIYYQNSID DKLLVEKIFA QYLVPHNLET EERMKCLYYL YASLDPNAVK
510 520 530 540 550
ALNEMWKCQN MLRSHVRELL DLHKQPTSEA NCSAMFGKLM TIAKNLPDPG
560 570 580 590 600
KAQDFVKKFN QVLGDDEKLR SQLELLISPT CSCKQADICV REIARKLANP
610 620 630 640 650
KQPTNPFLEM VKFLLERIAP VHIDSEAISA LVKLMNKSIE GTADDEEEGV
660 670 680 690 700
SPDTAIRSGL ELLKVLSFTH PTSFHSAETY ESLLQCLRME DDKVAEAAIQ
710 720 730 740 750
IFRNTGHKIE TDLPQIRSTL IPILHQKAKR GTPHQAKQAV HCIHAIFTNK
760 770 780 790 800
EVQLAQIFEP LSRSLNADVP EQLITPLVSL GHISMLAPDQ FASPMKSVVA
810 820 830 840 850
NFIVKDLLMN DRSTGEKNGK LWSPDEEVSP EVLAKVQAIK LLVRWLLGMK
860 870 880 890 900
NNQSKSANST LRLLSAMLVS EGDLTEQKRI SKSDMSRLRL AAGSAIMKLA
910 920 930 940 950
QEPCYHEIIT PEQFQLCALV INDECYQVRQ IFAQKLHKAL VKLLLPLEYM
960 970 980 990 1000
AIFALCAKDP VKERRAHARQ CLLKNISIRR EYIKQNPMAT EKLLSLLPEY
1010 1020 1030 1040 1050
VVPYMIHLLA HDPDFTRSQD VDQLRDIKEC LWFMLEVLMT KNENNSHAFM
1060 1070 1080 1090 1100
KKMAENIKLT RDAQSPDESK TNEKLYTVCD VALCVINSKS ALCNADSPKD
1110 1120 1130 1140 1150
PVLPMKFFTQ PEKDFCNDKS YISEETRVLL LTGKPKPAGV LGAVNKPLSA
1160 1170 1180 1190 1200
TGRKPYVRST GTETGSNINV NSELNPSTGN RSREQSSEAA ETGVSENEEN
1210 1220 1230 1240 1250
PVRIISVTPV KNIDPVKNKE INSDQATQGN ISSDRGKKRT VTAAGAENIQ
1260 1270 1280 1290 1300
QKTDEKVDES GPPAPSKPRR GRRPKSESQG NATKNDDLNK PINKGRKRAA
1310 1320 1330
VGQESPGGLE AGNAKAPKLQ DLAKKAAPAE RQIDLQR
Length:1,337
Mass (Da):150,830
Last modified:April 4, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA28EA9EF77499D9
GO
Isoform 2 (identifier: Q29RF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     591-600: REIARKLANP → VSKSYFTLFL
     601-1337: Missing.

Show »
Length:600
Mass (Da):69,000
Checksum:i12917E7912C86BFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9L6H0Y9L6_HUMAN
Sister chromatid cohesion protein P...
PDS5A
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9L9H0Y9L9_HUMAN
Sister chromatid cohesion protein P...
PDS5A
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9X6H0Y9X6_HUMAN
Sister chromatid cohesion protein P...
PDS5A
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI26226 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM82347 differs from that shown. Probable cloning artifact.Curated
The sequence CAH18263 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207D → G in AAM82347 (PubMed:15019998).Curated1
Sequence conflicti471Q → R in AAT52214 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052491591 – 600REIARKLANP → VSKSYFTLFL in isoform 2. 4 Publications10
Alternative sequenceiVSP_052492601 – 1337Missing in isoform 2. 4 PublicationsAdd BLAST737

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY550968 mRNA Translation: AAT52214.1
AK098331 mRNA Translation: BAC05286.1
BC041361 mRNA Translation: AAH41361.1
BC114218 mRNA Translation: AAI14219.1
BC126225 mRNA Translation: AAI26226.1 Different initiation.
AF294791 mRNA Translation: AAM82347.1 Sequence problems.
CR749425 mRNA Translation: CAH18263.1 Different initiation.
AB014548 mRNA Translation: BAA31623.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47045.1 [Q29RF7-1]
CCDS54759.1 [Q29RF7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001093869.1, NM_001100399.1 [Q29RF7-1]
NP_001093870.1, NM_001100400.1 [Q29RF7-3]
XP_011511974.1, XM_011513672.2 [Q29RF7-1]
XP_016863417.1, XM_017007928.1 [Q29RF7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303538; ENSP00000303427; ENSG00000121892 [Q29RF7-1]
ENST00000503396; ENSP00000426749; ENSG00000121892 [Q29RF7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23244

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23244

UCSC genome browser

More...
UCSCi
uc003guv.4 human [Q29RF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY550968 mRNA Translation: AAT52214.1
AK098331 mRNA Translation: BAC05286.1
BC041361 mRNA Translation: AAH41361.1
BC114218 mRNA Translation: AAI14219.1
BC126225 mRNA Translation: AAI26226.1 Different initiation.
AF294791 mRNA Translation: AAM82347.1 Sequence problems.
CR749425 mRNA Translation: CAH18263.1 Different initiation.
AB014548 mRNA Translation: BAA31623.1
CCDSiCCDS47045.1 [Q29RF7-1]
CCDS54759.1 [Q29RF7-3]
RefSeqiNP_001093869.1, NM_001100399.1 [Q29RF7-1]
NP_001093870.1, NM_001100400.1 [Q29RF7-3]
XP_011511974.1, XM_011513672.2 [Q29RF7-1]
XP_016863417.1, XM_017007928.1 [Q29RF7-1]

3D structure databases

SMRiQ29RF7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116848, 93 interactors
CORUMiQ29RF7
DIPiDIP-35419N
IntActiQ29RF7, 62 interactors
MINTiQ29RF7
STRINGi9606.ENSP00000303427

PTM databases

iPTMnetiQ29RF7
PhosphoSitePlusiQ29RF7
SwissPalmiQ29RF7

Polymorphism and mutation databases

BioMutaiPDS5A
DMDMi121947590

Proteomic databases

EPDiQ29RF7
jPOSTiQ29RF7
MassIVEiQ29RF7
MaxQBiQ29RF7
PaxDbiQ29RF7
PeptideAtlasiQ29RF7
PRIDEiQ29RF7
ProteomicsDBi61286 [Q29RF7-1]
61287 [Q29RF7-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23244
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303538; ENSP00000303427; ENSG00000121892 [Q29RF7-1]
ENST00000503396; ENSP00000426749; ENSG00000121892 [Q29RF7-3]
GeneIDi23244
KEGGihsa:23244
UCSCiuc003guv.4 human [Q29RF7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23244
DisGeNETi23244

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDS5A
HGNCiHGNC:29088 PDS5A
HPAiHPA036661
HPA036662
MIMi613200 gene
neXtProtiNX_Q29RF7
OpenTargetsiENSG00000121892
PharmGKBiPA162399027

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
GeneTreeiENSGT00940000155155
HOGENOMiHOG000230672
InParanoidiQ29RF7
KOiK11267
OMAiTIEPCIA
OrthoDBi69768at2759
PhylomeDBiQ29RF7
TreeFamiTF106415

Enzyme and pathway databases

ReactomeiR-HSA-2467813 Separation of Sister Chromatids
R-HSA-2468052 Establishment of Sister Chromatid Cohesion
R-HSA-2470946 Cohesin Loading onto Chromatin
R-HSA-2500257 Resolution of Sister Chromatid Cohesion

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PDS5A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PDS5A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23244

Pharos

More...
Pharosi
Q29RF7

Protein Ontology

More...
PROi
PR:Q29RF7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121892 Expressed in 238 organ(s), highest expression level in kidney
ExpressionAtlasiQ29RF7 baseline and differential
GenevisibleiQ29RF7 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDS5A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q29RF7
Secondary accession number(s): Q2TTR5
, Q68DF7, Q8N7J4, Q8NG14, Q9Y4D4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 4, 2006
Last modified: September 18, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again