UniProtKB - Q29IM7 (CASP8_DROPS)
Caspase-8
Dredd
Functioni
Effector of the programmed cell death (PCD) activators rpr, grim and W. May play an apoptotic role in the germline as well as soma. Role in immune response, required to resist Gram-negative bacterial infections by regulating DptA. Fadd interacts with Dredd, Fadd promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.
By similarityCatalytic activityi
- Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala). EC:3.4.22.61
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 352 | By similarity | 1 | |
Active sitei | 393 | By similarity | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB
- cysteine-type endopeptidase activity Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- innate immune response Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Apoptosis, Immunity, Innate immunity |
Protein family/group databases
MEROPSi | C14.040 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase-8 (EC:3.4.22.61)Alternative name(s): Death-related ced-3/NEDD2-like protein Cleaved into the following 2 chains: |
Gene namesi | Name:DreddBy similarity ORF Names:GA20387 |
Organismi | Drosophila pseudoobscura pseudoobscura (Fruit fly) |
Taxonomic identifieri | 46245 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000271414 | 1 – 242 | By similarityAdd BLAST | 242 | |
ChainiPRO_0000271415 | 243 – 405 | Caspase-8 subunit p15Sequence analysisAdd BLAST | 163 | |
PropeptideiPRO_0000271416 | 406 – 415 | By similarity | 10 | |
ChainiPRO_0000271417 | 416 – 511 | Caspase-8 subunit p10Sequence analysisAdd BLAST | 96 |
Keywords - PTMi
ZymogenExpressioni
Gene expression databases
Bgeei | FBgn0080382, Expressed in female reproductive system and 4 other tissues |
Interactioni
Subunit structurei
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 15 kDa (caspase-8 subunit p15) and a 10 kDa (caspase-8 subunit p10) subunit.
Interacts with the N-terminus of Fadd (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 7237.FBpp0273519 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
HOGENOMi | CLU_036904_4_2_1 |
InParanoidi | Q29IM7 |
OMAi | HGFEGAV |
PhylomeDBi | Q29IM7 |
Family and domain databases
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSGHNILTQL ESIDVLDLPY VERDLNFAQL VSLSFLLYGD EHSTATYILQ
60 70 80 90 100
KLLVLARATA SDWPHSDILS QYAKSKPQTW RKYLVEALCI IGARQVLRKL
110 120 130 140 150
GLCWQELRMH YLPHVGSIRV HIHPLLKSLY TICEELTLAQ RGRMVLDIKE
160 170 180 190 200
KNSVGDPLRF YDAEYLEIFL LDWLTRRLIR LGDFNANGSD VQLLIEYFKF
210 220 230 240 250
NDLHAQATLL VDTVNAYATS SCSPATPNVL LPMDGNGIAN ESSSPTAAAS
260 270 280 290 300
RPRAKNALQL SRENAGIALI INQQEFYRDA NDDYKVYLPP IELPLRNGTD
310 320 330 340 350
MDKQRLTNVF SMLGYKVEAH DNLDHLSMLH HIRQACKRSL LHESLVVCIL
360 370 380 390 400
SHGFEDAVYG ANSVALRISD IENVLCSYEN LYEKPKLVVI QACQQEDKEN
410 420 430 440 450
NALPYKINAS TKSPCQYLNM LRAMSTVPGF PALRHTQTGS WFIQSLCDAI
460 470 480 490 500
VEHSNSDHIA DILTIVINNV ANKRGNKNET MVPWTGGALR QHVYFPRTSA
510
TDKVVPDSPG L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8WCV0 | A0A6I8WCV0_DROPS | caspase-8 isoform X2 | LOC4816060 | 456 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH379063 Genomic DNA Translation: EAL32626.1 Sequence problems. |
RefSeqi | XP_001355567.1, XM_001355531.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0275081; FBpp0273519; FBgn0080382 |
GeneIDi | 4816060 |
KEGGi | dpo:Dpse_GA20387 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH379063 Genomic DNA Translation: EAL32626.1 Sequence problems. |
RefSeqi | XP_001355567.1, XM_001355531.2 |
3D structure databases
SMRi | Q29IM7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7237.FBpp0273519 |
Protein family/group databases
MEROPSi | C14.040 |
Genome annotation databases
EnsemblMetazoai | FBtr0275081; FBpp0273519; FBgn0080382 |
GeneIDi | 4816060 |
KEGGi | dpo:Dpse_GA20387 |
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
HOGENOMi | CLU_036904_4_2_1 |
InParanoidi | Q29IM7 |
OMAi | HGFEGAV |
PhylomeDBi | Q29IM7 |
Gene expression databases
Bgeei | FBgn0080382, Expressed in female reproductive system and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CASP8_DROPS | |
Accessioni | Q29IM7Primary (citable) accession number: Q29IM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | April 4, 2006 | |
Last modified: | February 23, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families