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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene namesi
Name:Pgam5
ORF Names:GA13269
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0073306 Dpse\GA13269

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 23HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002887901 – 289Serine/threonine-protein phosphatase Pgam5, mitochondrialAdd BLAST289

Expressioni

Gene expression databases

BgeeiFBgn0073306

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7237.FBpp0282923

Structurei

3D structure databases

ProteinModelPortaliQ29HG0
SMRiQ29HG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ29HG0
KOiK15637
OMAiHLTNRIP
PhylomeDBiQ29HG0

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit

Sequencei

Sequence statusi: Complete.

Q29HG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKFTAFACG TGAGLLTFYL TKLNEPKAAV HNSWTRSEKP VDPCALWDHN
60 70 80 90 100
WDLRDPKSLV KPVKNDLSQE QNRYNSELEK VVPKHARHII LIRHGEYLDV
110 120 130 140 150
GDTDETHHLT ERGREQAKYT GKRLCELGIK WDKVIASTMV RAQETADIIL
160 170 180 190 200
NEIDYEKAKV KNCAFLREGA PIPPQPPVGH WKPEASQFFR DGARIEAAFR
210 220 230 240 250
RYFYRAYPDQ TKDSYTLLVG HGNVIRYFVC RALQFPPEAW LRISINHASI
260 270 280
TWLTISPSGN VSIKYLGDTG FMPVNHLTNR IPRAAKNVV
Length:289
Mass (Da):33,069
Last modified:April 4, 2006 - v1
Checksum:i7F67EB09A3BFC81B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA Translation: EAL31798.1
RefSeqiXP_001354743.1, XM_001354707.3

Genome annotation databases

EnsemblMetazoaiFBtr0284485; FBpp0282923; FBgn0073306
GeneIDi4815173
KEGGidpo:Dpse_GA13269

Similar proteinsi

Entry informationi

Entry nameiPGAM5_DROPS
AccessioniPrimary (citable) accession number: Q29HG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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