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UniProtKB - Q29AU6 (RUMI_DROPS)
Protein
O-glucosyltransferase rumi
Gene
rumi
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Functioni
Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.
By similarity: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarityView all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 149 | Proton donor/acceptorBy similarity | 1 | |
Binding sitei | 235 | UDP-glucoseBy similarity | 1 |
GO - Molecular functioni
- EGF-domain serine glucosyltransferase activity Source: EnsemblMetazoa
- EGF-domain serine xylosyltransferase activity Source: EnsemblMetazoa
- glucosyltransferase activity Source: UniProtKB
- UDP-glucosyltransferase activity Source: UniProtKB
GO - Biological processi
- cell fate commitment Source: EnsemblMetazoa
- muscle tissue development Source: EnsemblMetazoa
- negative regulation of Notch signaling pathway Source: UniProtKB
- Notch signaling pathway Source: UniProtKB-KW
- positive regulation of Notch signaling pathway Source: EnsemblMetazoa
- protein glycosylation in endoplasmic reticulum Source: UniProtKB
- protein O-linked glycosylation via serine Source: UniProtKB
- rhabdomere development Source: EnsemblMetazoa
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Notch signaling pathway |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:rumiBy similarity ORF Names:GA16050 |
Organismi | Drosophila pseudoobscura pseudoobscura (Fruit fly) |
Taxonomic identifieri | 46245 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen PROSITE-ProRule annotationBy similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000342688 | 21 – 409 | O-glucosyltransferase rumiSequence analysisAdd BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 62 ↔ 73 | By similarity | ||
Disulfide bondi | 71 ↔ 376 | By similarity | ||
Disulfide bondi | 118 ↔ 124 | By similarity | ||
Disulfide bondi | 280 ↔ 303 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Gene expression databases
Bgeei | FBgn0076066, Expressed in female reproductive system and 4 other tissues |
Interactioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 120 | Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substratesBy similarity | 1 | |
Sitei | 230 | Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substratesBy similarity | 1 | |
Sitei | 257 | Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substratesBy similarity | 1 |
Protein-protein interaction databases
STRINGi | 7237.FBpp0283469 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 190 – 195 | Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substratesBy similarity | 6 | |
Regioni | 227 – 231 | UDP-glucose bindingBy similarity | 5 | |
Regioni | 274 – 276 | UDP-glucose bindingBy similarity | 3 | |
Regioni | 292 – 296 | UDP-glucose bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 406 – 409 | Prevents secretion from ERSequence analysis | 4 |
Sequence similaritiesi
Belongs to the glycosyltransferase 90 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2458, Eukaryota |
HOGENOMi | CLU_041919_1_0_1 |
InParanoidi | Q29AU6 |
OMAi | YLDIMYP |
PhylomeDBi | Q29AU6 |
Family and domain databases
InterProi | View protein in InterPro IPR006598, CAP10 |
Pfami | View protein in Pfam PF05686, Glyco_transf_90, 1 hit |
SMARTi | View protein in SMART SM00672, CAP10, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q29AU6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLINVVLIIL LVGLNGKASG QNQGLCSPDE NASCADSSDT QDEFSFNILR
60 70 80 90 100
KIKKALASYQ PCSSDANDAN CSCHAAVIKS DLAPYKATGV SRQMIESSAR
110 120 130 140 150
YGTRYKIYEK RLYREENCMF PARCQGIEHF LLPLVATLPD MDLVINTRDY
160 170 180 190 200
PQINMAWGNG AQGPILSFSK TKDHRDIMYP AWTFWAGGPA TKLHPRGIGR
210 220 230 240 250
WDLMREKLEK RAAAIPWSQK RELGFFRGSR TSDERDSLIL LSRRNPELVE
260 270 280 290 300
AQYTKNQGWK SPKDTLDAPP AGEVSFEDHC KYKYLFNFRG VAASFRLKHL
310 320 330 340 350
FLCQSLVFHV GDEWQEFFYD QLKPWVHYVP LKNYPSQQEY EELLTFFRKN
360 370 380 390 400
DALAQEIAQR GRDFIWQHLR MKDIKCYWRR LLKSYVKLLT YEVQPEDQLI
HIQPAKDEL
Sequence cautioni
The sequence EAL27253 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000070 Genomic DNA Translation: EAL27253.1 Sequence problems. |
RefSeqi | XP_001358116.1, XM_001358079.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0285031; FBpp0283469; FBgn0076066 |
GeneIDi | 4800928 |
KEGGi | dpo:Dpse_GA16050 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000070 Genomic DNA Translation: EAL27253.1 Sequence problems. |
RefSeqi | XP_001358116.1, XM_001358079.3 |
3D structure databases
SMRi | Q29AU6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7237.FBpp0283469 |
Genome annotation databases
EnsemblMetazoai | FBtr0285031; FBpp0283469; FBgn0076066 |
GeneIDi | 4800928 |
KEGGi | dpo:Dpse_GA16050 |
Phylogenomic databases
eggNOGi | KOG2458, Eukaryota |
HOGENOMi | CLU_041919_1_0_1 |
InParanoidi | Q29AU6 |
OMAi | YLDIMYP |
PhylomeDBi | Q29AU6 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Gene expression databases
Bgeei | FBgn0076066, Expressed in female reproductive system and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR006598, CAP10 |
Pfami | View protein in Pfam PF05686, Glyco_transf_90, 1 hit |
SMARTi | View protein in SMART SM00672, CAP10, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RUMI_DROPS | |
Accessioni | Q29AU6Primary (citable) accession number: Q29AU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | April 4, 2006 | |
Last modified: | September 29, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families