MICA

Functionⁱ

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

5 Publications

Miscellaneous

Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.1 Publication

GO - Molecular functionⁱ

natural killer cell lectin-like receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.40
  "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."
  Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T.
  Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH KLRK1, EFFECT OF VARIANT VAL-152 ON BINDING TO KLRK1.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Cytolysis, Host-virus interaction, Immunity

Biological process

Adaptive immunity, Cytolysis, Host-virus interaction, Immunity

Enzyme and pathway databases

PathwayCommonsⁱ	Q29983
Reactomeⁱ	R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SignaLinkⁱ	Q29983

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MHC class I polypeptide-related sequence A Short name: MIC-A
Gene namesⁱ	Name:MICAImported Synonyms:PERB11.11 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7090, MICA
MIMⁱ	600169, gene
neXtProtⁱ	NX_Q29983

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 307	ExtracellularSequence analysisAdd BLAST	284
Transmembraneⁱ	308 – 328	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	329 – 383	CytoplasmicSequence analysisAdd BLAST	55

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.

Psoriasis 1 (PSORS1)

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

Related information in OMIM

Psoriatic arthritis (PSORAS)1 Publication

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Disease descriptionAn inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

Related information in OMIM

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100507436
MIMⁱ	177900, phenotype 607507, phenotype
PharmGKBⁱ	PA30811

Miscellaneous databases

Pharosⁱ	Q29983, Tbio

Pharosⁱ

Q29983, Tbio

Genetic variation databases

BioMutaⁱ	MICA
DMDMⁱ	74740024

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Add BLAST		23
ChainⁱPRO_0000337146	24 – 383	MHC class I polypeptide-related sequence ASequence analysisAdd BLAST		360

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	31	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	59 ↔ 64	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	79	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	119 ↔ 187	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	210	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	220	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	225 ↔ 282	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	261	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.1 Publication

Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q29983
jPOSTⁱ	Q29983
MassIVEⁱ	Q29983
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q29983
PeptideAtlas More...PeptideAtlasⁱ	Q29983
PRIDEⁱ	Q29983
ProteomicsDBⁱ	61284 [Q29983-1]

PTM databases

GlyConnectⁱ	1510, 2 N-Linked glycans (2 sites)
GlyGenⁱ	Q29983, 6 sites, 2 N-linked glycans (2 sites)
iPTMnetⁱ	Q29983
PhosphoSitePlusⁱ	Q29983
SwissPalmⁱ	Q29983

Expressionⁱ

Tissue specificityⁱ

Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.7 Publications

Inductionⁱ

By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.8 Publications

Interactionⁱ

Subunit structureⁱ

Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction.

Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells.

Interacts with human cytomegalovirus/HHV-5 protein UL142.

7 Publications

(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL142.

1 Publication

Binary interactionsⁱ

Hide details

Q29983

With	#Exp.	IntAct
KLRK1 [P26718]	2	EBI-1031130,EBI-458344
LGALS3 [P17931]	2	EBI-1031130,EBI-1170392

GO - Molecular functionⁱ

natural killer cell lectin-like receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.40
  "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."
  Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T.
  Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH KLRK1, EFFECT OF VARIANT VAL-152 ON BINDING TO KLRK1.

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	319735, 88 interactors
CORUMⁱ	Q29983
Database of interacting proteins More...DIPⁱ	DIP-29681N
IntActⁱ	Q29983, 33 interactors
Molecular INTeraction database More...MINTⁱ	Q29983
STRINGⁱ	9606.ENSP00000413079

Miscellaneous databases

RNActⁱ	Q29983, protein

RNActⁱ

Q29983, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	26 – 37	Combined sources	12
Beta strandⁱ	40 – 51	Combined sources	12
Beta strandⁱ	54 – 59	Combined sources	6
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	71 – 75	Combined sources	5
Helixⁱ	79 – 81	Combined sources	3
Helixⁱ	82 – 101	Combined sources	20
Beta strandⁱ	109 – 121	Combined sources	13
Beta strandⁱ	127 – 135	Combined sources	9
Beta strandⁱ	138 – 144	Combined sources	7
Turnⁱ	145 – 148	Combined sources	4
Beta strandⁱ	149 – 151	Combined sources	3
Helixⁱ	156 – 170	Combined sources	15
Helixⁱ	177 – 196	Combined sources	20
Beta strandⁱ	208 – 213	Combined sources	6
Beta strandⁱ	217 – 233	Combined sources	17
Beta strandⁱ	236 – 241	Combined sources	6
Turnⁱ	248 – 250	Combined sources	3
Beta strandⁱ	251 – 253	Combined sources	3
Beta strandⁱ	260 – 262	Combined sources	3
Beta strandⁱ	264 – 273	Combined sources	10
Helixⁱ	277 – 279	Combined sources	3
Beta strandⁱ	280 – 286	Combined sources	7
Beta strandⁱ	289 – 294	Combined sources	6

Show more details

3D structure databases

SMRⁱ	Q29983
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q29983

EvolutionaryTraceⁱ

Q29983

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	207 – 296	Ig-like C1-typeSequence analysisAdd BLAST		90

Sequence similaritiesⁱ

Belongs to the MHC class I family. MIC subfamily.Sequence analysis

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502RU00, Eukaryota
InParanoidⁱ	Q29983
OMAⁱ	ICQGEEQ
Database of Orthologous Groups More...OrthoDBⁱ	1276422at2759
PhylomeDBⁱ	Q29983

Family and domain databases

Database of protein disorder More...DisProtⁱ	DP00670
Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit
SMARTⁱ	View protein in SMART SM00407, IGc1, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 Publication (identifier: Q29983-1) [UniParc]FASTA Add to basket

Also known as: MICA11 Publication

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH 
        60         70         80         90        100
LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL 
       110        120        130        140        150
AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETKEW 
       160        170        180        190        200
TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLKSGVV 
       210        220        230        240        250
LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR QDGVSLSHDT 
       260        270        280        290        300
QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV 
       310        320        330        340        350
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD 
       360        370        380 
QHPVGTSDHR DATQLGFQPL MSDLGSTGST EGA

Length:383

Mass (Da):42,915

Last modified:November 1, 1996 - v1

Checksum:ⁱ1FE084813DDA13A8

GO

Isoform 21 Publication (identifier: Q29983-2) [UniParc]FASTA Add to basket

Also known as: MICA21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
109-204: Missing.

« Hide

        10         20         30         40         50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH 
        60         70         80         90        100
LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL 
       110        120        130        140        150
AHIKDQKEVP PMVNVTRSEA SEGNITVTCR ASGFYPWNIT LSWRQDGVSL 
       160        170        180        190        200
SHDTQQWGDV LPDGNGTYQT WVATRICQGE EQRFTCYMEH SGNHSTHPVP 
       210        220        230        240        250
SGKVLVLQSH WQTFHVSAVA AAAIFVIIIF YVRCCKKKTS AAEGPELVSL 
       260        270        280 
QVLDQHPVGT SDHRDATQLG FQPLMSDLGS TGSTEGA

Note: Found in about 10% of examined clones.Curated

Show »

Length:287

Mass (Da):31,577

Checksum:ⁱ0D41D7919769F469

GO

Computationally mapped potential isoform sequencesⁱ

There are 17 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0G2JJ55	A0A0G2JJ55_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	194	Annotation score:
	A0A140T8Z6	A0A140T8Z6_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	245	Annotation score:
	A0A140T9M1	A0A140T9M1_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	247	Annotation score:
	Q96QC4	Q96QC4_HUMAN	MHC class I chain-related protein A MHC class I chain-related protein A (MHC class I polypeptide-related sequence A) (MHC class I polypeptide-related sequence A, isoform CRA_c) (MICA) (Stress inducible class I homolog) (cDNA FLJ60820, highly similar to Homo sapiens MHC class I polypeptide-related sequence A (MICA), mRNA)	MICA hCG_2001511	332	Annotation score:
	A0A140T986	A0A140T986_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	342	Annotation score:
	A0A1W2PPN1	A0A1W2PPN1_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	385	Annotation score:
	A0A140T9B8	A0A140T9B8_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	276	Annotation score:
	A0A140T9I5	A0A140T9I5_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	274	Annotation score:
	A0A1W2PRA6	A0A1W2PRA6_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	332	Annotation score:
	A0A669KAV5	A0A669KAV5_HUMAN	MHC class I polypeptide-related seq... MHC class I polypeptide-related sequence A	MICA	81	Annotation score:
There are more potential isoformsShow all

Polymorphismⁱ

The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_043625	29	R → P in allele MICA010, allele MICA025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding. 1 PublicationCorresponds to variant dbSNP:rs9380254Ensembl.	1
Natural variantⁱVAR_043626	37	W → G in allele MICA002, allele MICA011, allele MICA013, allele MICA014, allele MICA015, allele MICA017, allele MICA020, allele MICA022, allele MICA023, allele MICA030, allele MICA034, allele MICA035, allele MICA036, allele MICA041, allele MICA044, allele MICA046, allele MICA047, allele MICA052, allele MICA053 and allele MICA055. Corresponds to variant dbSNP:rs1063630Ensembl.	1
Natural variantⁱVAR_043627	47	T → A in allele MICA002, allele MICA004, allele MICA005, allele MICA006, allele MICA007, allele MICA008, allele MICA009, allele MICA010, allele MICA011, allele MICA013, allele MICA014, allele MICA015, allele MICA016, allele MICA017, allele MICA019, allele MICA020, allele MICA022, allele MICA023, allele MICA024, allele MICA025, allele MICA026, allele MICA027, allele MICA028, allele MICA029, allele MICA030, allele MICA031, allele MICA032, allele MICA033, allele MICA034, allele MICA035, allele MICA036, allele MICA037, allele MICA038, allele MICA039, allele MICA040, allele MICA041, allele MICA042, allele MICA043, allele MICA044, allele MICA045, allele MICA046, allele MICA047, allele MICA048, allele MICA049, allele MICA051, allele MICA052, allele MICA053, allele MICA054, allele MICA055 and allele MICA056. Corresponds to variant dbSNP:rs1051785Ensembl.	1
Natural variantⁱVAR_043628	49	V → G in allele MICA*041. Corresponds to variant dbSNP:rs17200158Ensembl.	1
Natural variantⁱVAR_043629	59	C → Y in allele MICA004, allele MICA005, allele MICA006, allele MICA008, allele MICA009, allele MICA010, allele MICA016, allele MICA019, allele MICA024, allele MICA025, allele MICA027, allele MICA028, allele MICA031, allele MICA032, allele MICA033, allele MICA042, allele MICA044, allele MICA048, allele MICA049, allele MICA051, allele MICA054 and allele MICA056. Corresponds to variant dbSNP:rs1051786Ensembl.	1
Natural variantⁱVAR_043630	114	Q → R in allele MICA*017. Corresponds to variant dbSNP:rs41558312Ensembl.	1
Natural variantⁱVAR_043631	128	R → K in allele MICA*036. Corresponds to variant dbSNP:rs41557113Ensembl.	1
Natural variantⁱVAR_043632	137	G → R in allele MICA014 and allele MICA015. Corresponds to variant dbSNP:rs41556715Ensembl.	1
Natural variantⁱVAR_043633	145	L → V in allele MICA004, allele MICA006, allele MICA009, allele MICA044 and allele MICA*049. Corresponds to variant dbSNP:rs1051790Ensembl.	1
Natural variantⁱVAR_043634	147	T → S in allele MICA*033. Corresponds to variant dbSNP:rs41539919Ensembl.	1
Natural variantⁱVAR_043635	148	K → E in allele MICA002, allele MICA004, allele MICA005, allele MICA006, allele MICA007, allele MICA008, allele MICA009, allele MICA010, allele MICA011, allele MICA012, allele MICA013, allele MICA014, allele MICA015, allele MICA016, allele MICA017, allele MICA018, allele MICA019, allele MICA020, allele MICA022, allele MICA023, allele MICA024, allele MICA025, allele MICA026, allele MICA027, allele MICA028, allele MICA029, allele MICA030, allele MICA032, allele MICA033, allele MICA034, allele MICA035, allele MICA036, allele MICA037, allele MICA038, allele MICA039, allele MICA041, allele MICA042, allele MICA043, allele MICA044, allele MICA045, allele MICA046, allele MICA047, allele MICA048, allele MICA049, allele MICA051, allele MICA052, allele MICA053, allele MICA054, allele MICA055 and allele MICA056. Corresponds to variant dbSNP:rs1051791Ensembl.	1
Natural variantⁱVAR_043636	152	M → V in allele MICA004, allele MICA005, allele MICA006, allele MICA008, allele MICA009, allele MICA010, allele MICA013, allele MICA016, allele MICA019, allele MICA022, allele MICA024, allele MICA027, allele MICA028, allele MICA033, allele MICA044, allele MICA048, allele MICA049, allele MICA053, allele MICA054 and allele MICA056; reduces binding affinity for KLRK1. Corresponds to variant dbSNP:rs1051792Ensembl.	1
Natural variantⁱVAR_043637	165	V → I in allele MICA*029. Corresponds to variant dbSNP:rs3819269Ensembl.	1
Natural variantⁱVAR_043638	174	M → V in allele MICA011 and allele MICA034. Corresponds to variant dbSNP:rs41560824Ensembl.	1
Natural variantⁱVAR_043639	179	H → L in allele MICA012, allele MICA032 and allele MICA*043. Corresponds to variant dbSNP:rs3819268Ensembl.	1
Natural variantⁱVAR_043640	196	K → E in allele MICA004, allele MICA006, allele MICA008, allele MICA009, allele MICA010, allele MICA013, allele MICA014, allele MICA016, allele MICA019, allele MICA022, allele MICA024, allele MICA027, allele MICA028, allele MICA033, allele MICA036, allele MICA044, allele MICA048, allele MICA049, allele MICA053, allele MICA054 and allele MICA*056. Corresponds to variant dbSNP:rs1051794Ensembl.	1
Natural variantⁱVAR_043641	198	G → S in allele MICA004, allele MICA006, allele MICA009, allele MICA010, allele MICA016, allele MICA019, allele MICA031, allele MICA033, allele MICA036, allele MICA044, allele MICA049, allele MICA054 and allele MICA*056. Corresponds to variant dbSNP:rs1131896Ensembl.	1
Natural variantⁱVAR_043642	199	V → I in allele MICA*006. Corresponds to variant dbSNP:rs41549718Ensembl.	1
Natural variantⁱVAR_043643	204	T → R in allele MICA004, allele MICA014, allele MICA032 and allele MICA044. Corresponds to variant dbSNP:rs1131897Ensembl.	1
Natural variantⁱVAR_043644	229	G → S in allele MICA004, allele MICA005, allele MICA006, allele MICA008, allele MICA009, allele MICA010, allele MICA016, allele MICA019, allele MICA022, allele MICA024, allele MICA027, allele MICA033, allele MICA034, allele MICA035, allele MICA037, allele MICA038, allele MICA039, allele MICA042, allele MICA044, allele MICA048, allele MICA049, allele MICA053, allele MICA054 and allele MICA056. Corresponds to variant dbSNP:rs1131898Ensembl.	1
Natural variantⁱVAR_043645	231	Y → C in allele MICA*046. Corresponds to variant dbSNP:rs41546915Ensembl.	1
Natural variantⁱVAR_043646	233	W → R in allele MICA004, allele MICA005, allele MICA006, allele MICA008, allele MICA009, allele MICA010, allele MICA016, allele MICA019, allele MICA022, allele MICA024, allele MICA027, allele MICA033, allele MICA034, allele MICA035, allele MICA037, allele MICA038, allele MICA039, allele MICA042, allele MICA044, allele MICA048, allele MICA049, allele MICA053, allele MICA054 and allele MICA056. Corresponds to variant dbSNP:rs1051798Ensembl.	1
Natural variantⁱVAR_043647	236	T → I in allele MICA008, allele MICA010, allele MICA016, allele MICA019, allele MICA022, allele MICA027, allele MICA033, allele MICA035, allele MICA037, allele MICA039, allele MICA042, allele MICA048, allele MICA053, allele MICA054 and allele MICA*056. Corresponds to variant dbSNP:rs1140700Ensembl.	1
Natural variantⁱVAR_043648	238	S → T in allele MICA004, allele MICA006, allele MICA008, allele MICA009, allele MICA010, allele MICA016, allele MICA019, allele MICA022, allele MICA024, allele MICA027, allele MICA033, allele MICA034, allele MICA035, allele MICA037, allele MICA038, allele MICA039, allele MICA042, allele MICA044, allele MICA048, allele MICA049, allele MICA053, allele MICA054 and allele MICA*056. Corresponds to variant dbSNP:rs1051799Ensembl.	1
Natural variantⁱVAR_043649	244	V → L in allele MICA016 and allele MICA039. Corresponds to variant dbSNP:rs41540613EnsemblClinVar.	1
Natural variantⁱVAR_043869	253	W → S in allele MICA*056. Corresponds to variant dbSNP:rs72558175Ensembl.	1
Natural variantⁱVAR_043650	274	Q → R in allele MICA005, allele MICA008, allele MICA010, allele MICA013, allele MICA016, allele MICA019, allele MICA022, allele MICA027, allele MICA033, allele MICA035, allele MICA037, allele MICA039, allele MICA042, allele MICA045, allele MICA048, allele MICA053, allele MICA054 and allele MICA056. Corresponds to variant dbSNP:rs1063635Ensembl.	1
Natural variantⁱVAR_043651	279	R → S in allele MICA*043. Corresponds to variant dbSNP:rs41557614Ensembl.	1
Natural variantⁱVAR_043652	291	S → G in allele MICA*054. Corresponds to variant dbSNP:rs61759927Ensembl.	1
Natural variantⁱVAR_043653	294	P → A in allele MICA011, allele MICA030 and allele MICA*047. Corresponds to variant dbSNP:rs41553616Ensembl.	1
Natural variantⁱVAR_043654	300 – 383	VLVLQ…STEGA → CWCFRVIGRHSMFLLLLLLL LLLLLFLLLLFSTSVVVRRK HQLQRVQSS in allele MICA015 and allele MICA017. Add BLAST	84
Natural variantⁱVAR_043655	318 – 383	AAIFV…STEGA → GCCYFCYYYFLCPLL in allele MICA008, allele MICA023, allele MICA028 and allele MICA053. Add BLAST	66
Natural variantⁱVAR_043656	319	A → AA in allele MICA010, allele MICA016, allele MICA019, allele MICA027, allele MICA033, allele MICA048, allele MICA054 and allele MICA056.	1
Natural variantⁱVAR_043657	319	A → AAA in allele MICA004, allele MICA006, allele MICA009, allele MICA011, allele MICA026, allele MICA047 and allele MICA*049.	1
Natural variantⁱVAR_043658	319	A → AAAA in allele MICA*050.	1
Natural variantⁱVAR_043659	319	A → AAAAA in allele MICA*055.	1
Natural variantⁱVAR_043660	319	A → AAAAAA in allele MICA002, allele MICA041, allele MICA046 and allele MICA052.	1
Natural variantⁱVAR_043661	319	A → AAAAAAA in allele MICA*020.	1
Natural variantⁱVAR_043662	328	V → I in allele MICA*052. Corresponds to variant dbSNP:rs72558178Ensembl.	1
Natural variantⁱVAR_043663	329	R → C in allele MICA002, allele MICA011, allele MICA020, allele MICA041, allele MICA043, allele MICA046, allele MICA047, allele MICA050 and allele MICA*052. Corresponds to variant dbSNP:rs41554412Ensembl.	1
Natural variantⁱVAR_043664	356	T → M in allele MICA*049. Corresponds to variant dbSNP:rs41546114Ensembl.	1
Natural variantⁱVAR_043665	373	D → A in allele MICA004, allele MICA006, allele MICA010, allele MICA011, allele MICA016, allele MICA019, allele MICA048 and allele MICA049. Corresponds to variant dbSNP:rs9266825Ensembl.	1
Natural variantⁱVAR_043666	377	T → A in allele MICA*011. Corresponds to variant dbSNP:rs41545814Ensembl.	1
Natural variantⁱVAR_043667	383	A → T in allele MICA*018. Corresponds to variant dbSNP:rs1882Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055366	109 – 204	Missing in isoform 2. 1 PublicationAdd BLAST		96

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L14848 mRNA Translation: AAA21718.1 X92841 Genomic DNA Translation: CAA63427.1 AL845443 Genomic DNA Translation: CAI41907.1 CR847852 Genomic DNA Translation: CAQ11015.1 BC016929 mRNA Translation: AAH16929.1 BG114064 mRNA No translation available. L29406 Genomic DNA No translation available. L29408 Genomic DNA No translation available. L29409 Genomic DNA No translation available. L29411 Genomic DNA No translation available. U56940 Genomic DNA Translation: AAB41060.1 U56941 Genomic DNA Translation: AAB41061.1 U56942 Genomic DNA Translation: AAB41062.1 U56943 Genomic DNA Translation: AAB41063.1 U56944 Genomic DNA Translation: AAB41064.1 U56945 Genomic DNA Translation: AAB41065.1 U56946 Genomic DNA Translation: AAB41066.1 U56947 Genomic DNA Translation: AAB41067.1 U56948 Genomic DNA Translation: AAB41068.1 U56949 Genomic DNA Translation: AAB41069.1 U56950 Genomic DNA Translation: AAB41070.1 U56951 Genomic DNA Translation: AAB41071.1 U56952 Genomic DNA Translation: AAB41072.1 U56953 Genomic DNA Translation: AAB41073.1 U56954 Genomic DNA Translation: AAB41074.1 U56955 Genomic DNA Translation: AAB41075.1 Y16801 Genomic DNA Translation: CAA76393.1 Y16802 Genomic DNA Translation: CAA76394.1 Y16803 Genomic DNA Translation: CAA76395.1 Y16804 Genomic DNA Translation: CAA76396.1 Y16805 Genomic DNA Translation: CAA76397.1 Y16806 Genomic DNA Translation: CAA76398.1 Y16807 Genomic DNA Translation: CAA76399.1 Y16808 Genomic DNA Translation: CAA76400.1 Y16809 Genomic DNA Translation: CAA76401.1 Y16810 Genomic DNA Translation: CAA76402.1 Y16811 Genomic DNA Translation: CAA76403.1 Y18110 Genomic DNA Translation: CAA77029.1 Y18111 Genomic DNA Translation: CAA77030.1 Y18112 Genomic DNA Translation: CAA77031.1 AF097403 Genomic DNA Translation: AAD27006.1 AF097404 Genomic DNA Translation: AAD27007.1 AF097405 Genomic DNA Translation: AAD27008.1 AF097406 Genomic DNA Translation: AAD27009.1 AB015600 Genomic DNA Translation: BAA29034.1 AJ563426 Genomic DNA Translation: CAD91415.1 AH007168 Genomic DNA Translation: AAD01474.1 AH007170 Genomic DNA Translation: AAD01476.1 AH007171 Genomic DNA Translation: AAD01477.1 AH007173 Genomic DNA Translation: AAD01479.1 AH007174 Genomic DNA Translation: AAD01480.1 AH007186 Genomic DNA Translation: AAD01492.1 AH007175 Genomic DNA Translation: AAD01481.1 AH007176 Genomic DNA Translation: AAD01482.1 AH007177 Genomic DNA Translation: AAD01483.1 AH007178 Genomic DNA Translation: AAD01484.1 AH007179 Genomic DNA Translation: AAD01485.1 AH007180 Genomic DNA Translation: AAD01486.1 AH007182 Genomic DNA Translation: AAD01488.1 AH007183 Genomic DNA Translation: AAD01489.1 AH007184 Genomic DNA Translation: AAD01490.1 AH007185 Genomic DNA Translation: AAD01491.1 AH008136 Genomic DNA Translation: AAD52060.1 AH008137 Genomic DNA Translation: AAD52061.1 AH008138 Genomic DNA Translation: AAD52062.1 AH008139 Genomic DNA Translation: AAD52063.1 AH008140 Genomic DNA Translation: AAD52064.1 AH008141 Genomic DNA Translation: AAD52065.1 AH008142 Genomic DNA Translation: AAD52066.1 AH008143 Genomic DNA Translation: AAD52067.1 AH008144 Genomic DNA Translation: AAD52068.1 AH008145 Genomic DNA Translation: AAD52069.1 AH008146 Genomic DNA Translation: AAD52070.1 AH008147 Genomic DNA Translation: AAD52071.1 AH008148 Genomic DNA Translation: AAD52072.1 AH007169 Genomic DNA Translation: AAD01475.1 AH007172 Genomic DNA Translation: AAD01478.1 AH007167 Genomic DNA Translation: AAD01473.1 AH007181 Genomic DNA Translation: AAD01487.1 AH010819 Genomic DNA Translation: AAK58536.1 AH011143 Genomic DNA Translation: AAL13171.1 AH010820 Genomic DNA Translation: AAK58537.1 AH010821 Genomic DNA Translation: AAK58538.1 AH010545 Genomic DNA Translation: AAK19622.1 AH010526 Genomic DNA Translation: AAK17997.1 AH010568 Genomic DNA Translation: AAK25770.1 AH010569 Genomic DNA Translation: AAK25771.1 AH010532 Genomic DNA Translation: AAK18281.1 AH010546 Genomic DNA Translation: AAK19623.1 AH010560 Genomic DNA Translation: AAK20897.1 AH010561 Genomic DNA Translation: AAK20898.1 AH010587 Genomic DNA Translation: AAK27364.1 AH010562 Genomic DNA Translation: AAK20899.1 AH010571 Genomic DNA Translation: AAK26323.1 AH010572 Genomic DNA Translation: AAK26324.1 AH010740 Genomic DNA Translation: AAK51140.1 AJ250499 Genomic DNA Translation: CAC14280.1 AJ250500 Genomic DNA Translation: CAC14281.1 AJ250501 Genomic DNA Translation: CAC14282.1 AJ250502 Genomic DNA Translation: CAC14283.1 AJ250503 Genomic DNA Translation: CAC14284.1 AJ250504 Genomic DNA Translation: CAC14285.1 AJ250505 Genomic DNA Translation: CAC14286.1 AJ250506 Genomic DNA Translation: CAC14287.1 AJ250507 Genomic DNA Translation: CAC14288.1 AJ250802 Genomic DNA Translation: CAC15380.1 AJ250803 Genomic DNA Translation: CAC15381.1 AJ250804 Genomic DNA Translation: CAC15382.1 AJ250805 Genomic DNA Translation: CAC15383.1 AJ250990 Genomic DNA Translation: CAC16142.1 AJ250991 Genomic DNA Translation: CAC16143.1 AJ271789 Genomic DNA Translation: CAC27561.1 AY603357 Genomic DNA Translation: AAV39504.1 AJ249394 Genomic DNA Translation: CAB71317.1 AJ295250, AJ295251 Genomic DNA Translation: CAC88121.1 AJ580805 Genomic DNA Translation: CAE45581.1 AJ580806 Genomic DNA Translation: CAE45582.2 AH014149 Genomic DNA Translation: AAU95382.1 AM899996 Genomic DNA Translation: CAP12057.1 EU254723 Genomic DNA Translation: ABX54884.1 AM944063 Genomic DNA Translation: CAQ16171.1 AH006330 Genomic DNA Translation: AAC28941.1 AH006331 Genomic DNA Translation: AAC28942.1 AH006332 Genomic DNA Translation: AAC28943.1 AH006333 Genomic DNA Translation: AAC28944.1 AH006334 Genomic DNA Translation: AAC28945.1 AH007472 Genomic DNA Translation: AAD19598.1 AH007473 Genomic DNA Translation: AAD19599.1 AH007474 Genomic DNA Translation: AAD19600.1 AH007475 Genomic DNA Translation: AAD19601.1 AH007476 Genomic DNA Translation: AAD19602.1 AH007477 Genomic DNA Translation: AAD19603.1 AF106652, AF106650, AF106651 Genomic DNA Translation: AAD19604.1 AH007479 Genomic DNA Translation: AAD19605.1 EU267602 Genomic DNA Translation: ABX60404.1 AY095537 Genomic DNA Translation: AAM34484.1
PIRⁱ	A55739
NCBI Reference Sequences More...RefSeqⁱ	NP_000238.1, NM_000247.2 [Q29983-1]

Genome annotation databases

Ensemblⁱ	ENST00000400325; ENSP00000383179; ENSG00000183214 ENST00000418465; ENSP00000402134; ENSG00000235233 ENST00000547609; ENSP00000446963; ENSG00000183214
GeneIDⁱ	100507436
KEGGⁱ	hsa:100507436
UCSC genome browser More...UCSCⁱ	uc011ind.3, human [Q29983-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q29983	MHC class I-like molecule PERB11.1-54.1 (Fragment)		HUMAN		44	UniRef100_Q29983
MHC class I-like molecule PERB11.1-18.2 (Fragment)		HUMAN		44
+1
Q29983-2	MHC class I polypeptide-related sequence A (Fragment)		HUMAN		274	UniRef100_Q29983-2

Protein	Similar proteins		Species	Score	Length	Source
Q29983	MHC class I-like molecule PERB11.1-54.1 (Fragment)		HUMAN		44	UniRef90_Q29983
MHC class I polypeptide-related sequence B		GORGO		387
MHC class I chain-related protein (Fragment)		western gorilla		322
MHC class I-like molecule PERB11.1-18.2 (Fragment)		HUMAN		44
MHC Class I chain-related protein		HUMAN		388
+186
Q29983-2	MHC class I polypeptide-related sequence A (Fragment)		HUMAN		274	UniRef90_Q29983-2
MHC class I polypeptide-related sequence A (Fragment)		HUMAN		276

Protein	Similar proteins		Species	Score	Length	Source
Q29983	MHC class I polypeptide-related sequence B	)	HUMAN		383	UniRef50_Q29983
MHC class I polypeptide-related sequence B		GORGO		387
MHC class I chain-related protein (Fragment)		western gorilla		322
MHC class I antigen (Fragment)		MACFA		309
MHC class I polypeptide-related sequence B		MANLE		334
+436
Q29983-2	MHC class I polypeptide-related sequence A (Fragment)		HUMAN		274	UniRef50_Q29983-2
MHC class I chain-related protein (Fragment)		HYLLA		270
MHC class I chain-related protein (Fragment)		PONPY		275
MHC class I polypeptide-related sequence A (Fragment)		HUMAN		276
MHC class I related chain A isoform B1		HUMAN		288
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L14848 mRNA Translation: AAA21718.1 X92841 Genomic DNA Translation: CAA63427.1 AL845443 Genomic DNA Translation: CAI41907.1 CR847852 Genomic DNA Translation: CAQ11015.1 BC016929 mRNA Translation: AAH16929.1 BG114064 mRNA No translation available. L29406 Genomic DNA No translation available. L29408 Genomic DNA No translation available. L29409 Genomic DNA No translation available. L29411 Genomic DNA No translation available. U56940 Genomic DNA Translation: AAB41060.1 U56941 Genomic DNA Translation: AAB41061.1 U56942 Genomic DNA Translation: AAB41062.1 U56943 Genomic DNA Translation: AAB41063.1 U56944 Genomic DNA Translation: AAB41064.1 U56945 Genomic DNA Translation: AAB41065.1 U56946 Genomic DNA Translation: AAB41066.1 U56947 Genomic DNA Translation: AAB41067.1 U56948 Genomic DNA Translation: AAB41068.1 U56949 Genomic DNA Translation: AAB41069.1 U56950 Genomic DNA Translation: AAB41070.1 U56951 Genomic DNA Translation: AAB41071.1 U56952 Genomic DNA Translation: AAB41072.1 U56953 Genomic DNA Translation: AAB41073.1 U56954 Genomic DNA Translation: AAB41074.1 U56955 Genomic DNA Translation: AAB41075.1 Y16801 Genomic DNA Translation: CAA76393.1 Y16802 Genomic DNA Translation: CAA76394.1 Y16803 Genomic DNA Translation: CAA76395.1 Y16804 Genomic DNA Translation: CAA76396.1 Y16805 Genomic DNA Translation: CAA76397.1 Y16806 Genomic DNA Translation: CAA76398.1 Y16807 Genomic DNA Translation: CAA76399.1 Y16808 Genomic DNA Translation: CAA76400.1 Y16809 Genomic DNA Translation: CAA76401.1 Y16810 Genomic DNA Translation: CAA76402.1 Y16811 Genomic DNA Translation: CAA76403.1 Y18110 Genomic DNA Translation: CAA77029.1 Y18111 Genomic DNA Translation: CAA77030.1 Y18112 Genomic DNA Translation: CAA77031.1 AF097403 Genomic DNA Translation: AAD27006.1 AF097404 Genomic DNA Translation: AAD27007.1 AF097405 Genomic DNA Translation: AAD27008.1 AF097406 Genomic DNA Translation: AAD27009.1 AB015600 Genomic DNA Translation: BAA29034.1 AJ563426 Genomic DNA Translation: CAD91415.1 AH007168 Genomic DNA Translation: AAD01474.1 AH007170 Genomic DNA Translation: AAD01476.1 AH007171 Genomic DNA Translation: AAD01477.1 AH007173 Genomic DNA Translation: AAD01479.1 AH007174 Genomic DNA Translation: AAD01480.1 AH007186 Genomic DNA Translation: AAD01492.1 AH007175 Genomic DNA Translation: AAD01481.1 AH007176 Genomic DNA Translation: AAD01482.1 AH007177 Genomic DNA Translation: AAD01483.1 AH007178 Genomic DNA Translation: AAD01484.1 AH007179 Genomic DNA Translation: AAD01485.1 AH007180 Genomic DNA Translation: AAD01486.1 AH007182 Genomic DNA Translation: AAD01488.1 AH007183 Genomic DNA Translation: AAD01489.1 AH007184 Genomic DNA Translation: AAD01490.1 AH007185 Genomic DNA Translation: AAD01491.1 AH008136 Genomic DNA Translation: AAD52060.1 AH008137 Genomic DNA Translation: AAD52061.1 AH008138 Genomic DNA Translation: AAD52062.1 AH008139 Genomic DNA Translation: AAD52063.1 AH008140 Genomic DNA Translation: AAD52064.1 AH008141 Genomic DNA Translation: AAD52065.1 AH008142 Genomic DNA Translation: AAD52066.1 AH008143 Genomic DNA Translation: AAD52067.1 AH008144 Genomic DNA Translation: AAD52068.1 AH008145 Genomic DNA Translation: AAD52069.1 AH008146 Genomic DNA Translation: AAD52070.1 AH008147 Genomic DNA Translation: AAD52071.1 AH008148 Genomic DNA Translation: AAD52072.1 AH007169 Genomic DNA Translation: AAD01475.1 AH007172 Genomic DNA Translation: AAD01478.1 AH007167 Genomic DNA Translation: AAD01473.1 AH007181 Genomic DNA Translation: AAD01487.1 AH010819 Genomic DNA Translation: AAK58536.1 AH011143 Genomic DNA Translation: AAL13171.1 AH010820 Genomic DNA Translation: AAK58537.1 AH010821 Genomic DNA Translation: AAK58538.1 AH010545 Genomic DNA Translation: AAK19622.1 AH010526 Genomic DNA Translation: AAK17997.1 AH010568 Genomic DNA Translation: AAK25770.1 AH010569 Genomic DNA Translation: AAK25771.1 AH010532 Genomic DNA Translation: AAK18281.1 AH010546 Genomic DNA Translation: AAK19623.1 AH010560 Genomic DNA Translation: AAK20897.1 AH010561 Genomic DNA Translation: AAK20898.1 AH010587 Genomic DNA Translation: AAK27364.1 AH010562 Genomic DNA Translation: AAK20899.1 AH010571 Genomic DNA Translation: AAK26323.1 AH010572 Genomic DNA Translation: AAK26324.1 AH010740 Genomic DNA Translation: AAK51140.1 AJ250499 Genomic DNA Translation: CAC14280.1 AJ250500 Genomic DNA Translation: CAC14281.1 AJ250501 Genomic DNA Translation: CAC14282.1 AJ250502 Genomic DNA Translation: CAC14283.1 AJ250503 Genomic DNA Translation: CAC14284.1 AJ250504 Genomic DNA Translation: CAC14285.1 AJ250505 Genomic DNA Translation: CAC14286.1 AJ250506 Genomic DNA Translation: CAC14287.1 AJ250507 Genomic DNA Translation: CAC14288.1 AJ250802 Genomic DNA Translation: CAC15380.1 AJ250803 Genomic DNA Translation: CAC15381.1 AJ250804 Genomic DNA Translation: CAC15382.1 AJ250805 Genomic DNA Translation: CAC15383.1 AJ250990 Genomic DNA Translation: CAC16142.1 AJ250991 Genomic DNA Translation: CAC16143.1 AJ271789 Genomic DNA Translation: CAC27561.1 AY603357 Genomic DNA Translation: AAV39504.1 AJ249394 Genomic DNA Translation: CAB71317.1 AJ295250, AJ295251 Genomic DNA Translation: CAC88121.1 AJ580805 Genomic DNA Translation: CAE45581.1 AJ580806 Genomic DNA Translation: CAE45582.2 AH014149 Genomic DNA Translation: AAU95382.1 AM899996 Genomic DNA Translation: CAP12057.1 EU254723 Genomic DNA Translation: ABX54884.1 AM944063 Genomic DNA Translation: CAQ16171.1 AH006330 Genomic DNA Translation: AAC28941.1 AH006331 Genomic DNA Translation: AAC28942.1 AH006332 Genomic DNA Translation: AAC28943.1 AH006333 Genomic DNA Translation: AAC28944.1 AH006334 Genomic DNA Translation: AAC28945.1 AH007472 Genomic DNA Translation: AAD19598.1 AH007473 Genomic DNA Translation: AAD19599.1 AH007474 Genomic DNA Translation: AAD19600.1 AH007475 Genomic DNA Translation: AAD19601.1 AH007476 Genomic DNA Translation: AAD19602.1 AH007477 Genomic DNA Translation: AAD19603.1 AF106652, AF106650, AF106651 Genomic DNA Translation: AAD19604.1 AH007479 Genomic DNA Translation: AAD19605.1 EU267602 Genomic DNA Translation: ABX60404.1 AY095537 Genomic DNA Translation: AAM34484.1
PIRⁱ	A55739
RefSeqⁱ	NP_000238.1, NM_000247.2 [Q29983-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1B3J	X-ray	3.00	A	24-297	[»]
	1HYR	X-ray	2.70	C	24-297	[»]
SMRⁱ	Q29983
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	319735, 88 interactors
CORUMⁱ	Q29983
DIPⁱ	DIP-29681N
IntActⁱ	Q29983, 33 interactors
MINTⁱ	Q29983
STRINGⁱ	9606.ENSP00000413079

PTM databases

GlyConnectⁱ	1510, 2 N-Linked glycans (2 sites)
GlyGenⁱ	Q29983, 6 sites, 2 N-linked glycans (2 sites)
iPTMnetⁱ	Q29983
PhosphoSitePlusⁱ	Q29983
SwissPalmⁱ	Q29983

Genetic variation databases

BioMutaⁱ	MICA
DMDMⁱ	74740024

Proteomic databases

EPDⁱ	Q29983
jPOSTⁱ	Q29983
MassIVEⁱ	Q29983
MaxQBⁱ	Q29983
PeptideAtlasⁱ	Q29983
PRIDEⁱ	Q29983
ProteomicsDBⁱ	61284 [Q29983-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	100507436

DNASUⁱ

100507436

Genome annotation databases

Ensemblⁱ	ENST00000400325; ENSP00000383179; ENSG00000183214 ENST00000418465; ENSP00000402134; ENSG00000235233 ENST00000547609; ENSP00000446963; ENSG00000183214
GeneIDⁱ	100507436
KEGGⁱ	hsa:100507436
UCSCⁱ	uc011ind.3, human [Q29983-1]

Organism-specific databases

CTDⁱ	100507436
DisGeNETⁱ	100507436
GeneCardsⁱ	MICA
HGNCⁱ	HGNC:7090, MICA
MIMⁱ	177900, phenotype 600169, gene 607507, phenotype
neXtProtⁱ	NX_Q29983
PharmGKBⁱ	PA30811
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502RU00, Eukaryota
InParanoidⁱ	Q29983
OMAⁱ	ICQGEEQ
OrthoDBⁱ	1276422at2759
PhylomeDBⁱ	Q29983

Enzyme and pathway databases

PathwayCommonsⁱ	Q29983
Reactomeⁱ	R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SignaLinkⁱ	Q29983

Miscellaneous databases

BioGRID-ORCSⁱ	100507436, 1 hit in 1003 CRISPR screens
ChiTaRSⁱ	MICA, human
EvolutionaryTraceⁱ	Q29983
GeneWikiⁱ	MHC_class_I_polypeptide-related_sequence_A
GenomeRNAiⁱ	100507436
Pharosⁱ	Q29983, Tbio
Protein Ontology More...PROⁱ	PR:Q29983
RNActⁱ	Q29983, protein
SOURCEⁱ	Search...

Family and domain databases

DisProtⁱ	DP00670
Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog
Pfamⁱ	View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit
SMARTⁱ	View protein in SMART SM00407, IGc1, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MICA_HUMAN
Accessionⁱ	Q29983Primary (citable) accession number: Q29983 Secondary accession number(s): A8KQR0 Q9UE11
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	November 1, 1996
	Last modified:	February 23, 2022
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q29983 (MICA_HUMAN)

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MHC class I polypeptide-related sequence A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Psoriasis 1 (PSORS1)

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q29983

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ