UniProtKB - Q29983 (MICA_HUMAN)
MHC class I polypeptide-related sequence A
MICA
Functioni
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
5 PublicationsMiscellaneous
GO - Molecular functioni
- natural killer cell lectin-like receptor binding Source: UniProtKB
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- cytolysis Source: UniProtKB-KW
- defense response to bacterium Source: UniProtKB
- defense response to virus Source: UniProtKB
- gamma-delta T cell activation Source: UniProtKB
- immune response to tumor cell Source: UniProtKB
- natural killer cell mediated cytotoxicity Source: UniProtKB
- negative regulation of natural killer cell activation Source: CACAO
- negative regulation of natural killer cell mediated cytotoxicity Source: CACAO
- response to heat Source: UniProtKB
- T cell mediated cytotoxicity Source: UniProtKB
Keywordsi
Biological process | Adaptive immunity, Cytolysis, Host-virus interaction, Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q29983 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q29983 |
Names & Taxonomyi
Protein namesi | Recommended name: MHC class I polypeptide-related sequence AShort name: MIC-A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7090, MICA |
MIMi | 600169, gene |
neXtProti | NX_Q29983 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 3 Publications
Plasma membrane
- Cell membrane 3 Publications; Single-pass type I membrane protein 3 Publications
Note: Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.3 Publications
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 307 | ExtracellularSequence analysisAdd BLAST | 284 | |
Transmembranei | 308 – 328 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 329 – 383 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Psoriasis 1 (PSORS1)
Psoriatic arthritis (PSORAS)1 Publication
Organism-specific databases
DisGeNETi | 100507436 |
MIMi | 177900, phenotype 607507, phenotype |
PharmGKBi | PA30811 |
Miscellaneous databases
Pharosi | Q29983, Tbio |
Genetic variation databases
BioMutai | MICA |
DMDMi | 74740024 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Add BLAST | 23 | |
ChainiPRO_0000337146 | 24 – 383 | MHC class I polypeptide-related sequence ASequence analysisAdd BLAST | 360 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 59 ↔ 64 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 79 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 119 ↔ 187 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 210 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 225 ↔ 282 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 261 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q29983 |
jPOSTi | Q29983 |
MassIVEi | Q29983 |
MaxQBi | Q29983 |
PeptideAtlasi | Q29983 |
PRIDEi | Q29983 |
ProteomicsDBi | 61284 [Q29983-1] |
PTM databases
GlyConnecti | 1510, 2 N-Linked glycans (2 sites) |
GlyGeni | Q29983, 6 sites, 2 N-linked glycans (2 sites) |
iPTMneti | Q29983 |
PhosphoSitePlusi | Q29983 |
SwissPalmi | Q29983 |
Expressioni
Tissue specificityi
Inductioni
Interactioni
Subunit structurei
Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction.
Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells.
Interacts with human cytomegalovirus/HHV-5 protein UL142.
7 Publications(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL142.
1 PublicationBinary interactionsi
GO - Molecular functioni
- natural killer cell lectin-like receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 319735, 88 interactors |
CORUMi | Q29983 |
DIPi | DIP-29681N |
IntActi | Q29983, 33 interactors |
MINTi | Q29983 |
STRINGi | 9606.ENSP00000413079 |
Miscellaneous databases
RNActi | Q29983, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q29983 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q29983 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 207 – 296 | Ig-like C1-typeSequence analysisAdd BLAST | 90 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU00, Eukaryota |
InParanoidi | Q29983 |
OMAi | ICQGEEQ |
OrthoDBi | 1276422at2759 |
PhylomeDBi | Q29983 |
Family and domain databases
DisProti | DP00670 |
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH
60 70 80 90 100
LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL
110 120 130 140 150
AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETKEW
160 170 180 190 200
TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLKSGVV
210 220 230 240 250
LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR QDGVSLSHDT
260 270 280 290 300
QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV
310 320 330 340 350
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD
360 370 380
QHPVGTSDHR DATQLGFQPL MSDLGSTGST EGA
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JJ55 | A0A0G2JJ55_HUMAN | MHC class I polypeptide-related seq... | MICA | 194 | Annotation score: | ||
A0A140T8Z6 | A0A140T8Z6_HUMAN | MHC class I polypeptide-related seq... | MICA | 245 | Annotation score: | ||
A0A140T9M1 | A0A140T9M1_HUMAN | MHC class I polypeptide-related seq... | MICA | 247 | Annotation score: | ||
Q96QC4 | Q96QC4_HUMAN | MHC class I chain-related protein A | MICA hCG_2001511 | 332 | Annotation score: | ||
A0A140T986 | A0A140T986_HUMAN | MHC class I polypeptide-related seq... | MICA | 342 | Annotation score: | ||
A0A1W2PPN1 | A0A1W2PPN1_HUMAN | MHC class I polypeptide-related seq... | MICA | 385 | Annotation score: | ||
A0A140T9B8 | A0A140T9B8_HUMAN | MHC class I polypeptide-related seq... | MICA | 276 | Annotation score: | ||
A0A140T9I5 | A0A140T9I5_HUMAN | MHC class I polypeptide-related seq... | MICA | 274 | Annotation score: | ||
A0A1W2PRA6 | A0A1W2PRA6_HUMAN | MHC class I polypeptide-related seq... | MICA | 332 | Annotation score: | ||
A0A669KAV5 | A0A669KAV5_HUMAN | MHC class I polypeptide-related seq... | MICA | 81 | Annotation score: | ||
There are more potential isoformsShow all |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043625 | 29 | R → P in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding. 1 PublicationCorresponds to variant dbSNP:rs9380254Ensembl. | 1 | |
Natural variantiVAR_043626 | 37 | W → G in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055. Corresponds to variant dbSNP:rs1063630Ensembl. | 1 | |
Natural variantiVAR_043627 | 47 | T → A in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056. Corresponds to variant dbSNP:rs1051785Ensembl. | 1 | |
Natural variantiVAR_043628 | 49 | V → G in allele MICA*041. Corresponds to variant dbSNP:rs17200158Ensembl. | 1 | |
Natural variantiVAR_043629 | 59 | C → Y in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051786Ensembl. | 1 | |
Natural variantiVAR_043630 | 114 | Q → R in allele MICA*017. Corresponds to variant dbSNP:rs41558312Ensembl. | 1 | |
Natural variantiVAR_043631 | 128 | R → K in allele MICA*036. Corresponds to variant dbSNP:rs41557113Ensembl. | 1 | |
Natural variantiVAR_043632 | 137 | G → R in allele MICA*014 and allele MICA*015. Corresponds to variant dbSNP:rs41556715Ensembl. | 1 | |
Natural variantiVAR_043633 | 145 | L → V in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*044 and allele MICA*049. Corresponds to variant dbSNP:rs1051790Ensembl. | 1 | |
Natural variantiVAR_043634 | 147 | T → S in allele MICA*033. Corresponds to variant dbSNP:rs41539919Ensembl. | 1 | |
Natural variantiVAR_043635 | 148 | K → E in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*012, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*018, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056. Corresponds to variant dbSNP:rs1051791Ensembl. | 1 | |
Natural variantiVAR_043636 | 152 | M → V in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056; reduces binding affinity for KLRK1. Corresponds to variant dbSNP:rs1051792Ensembl. | 1 | |
Natural variantiVAR_043637 | 165 | V → I in allele MICA*029. Corresponds to variant dbSNP:rs3819269Ensembl. | 1 | |
Natural variantiVAR_043638 | 174 | M → V in allele MICA*011 and allele MICA*034. Corresponds to variant dbSNP:rs41560824Ensembl. | 1 | |
Natural variantiVAR_043639 | 179 | H → L in allele MICA*012, allele MICA*032 and allele MICA*043. Corresponds to variant dbSNP:rs3819268Ensembl. | 1 | |
Natural variantiVAR_043640 | 196 | K → E in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*014, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051794Ensembl. | 1 | |
Natural variantiVAR_043641 | 198 | G → S in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*031, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*049, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1131896Ensembl. | 1 | |
Natural variantiVAR_043642 | 199 | V → I in allele MICA*006. Corresponds to variant dbSNP:rs41549718Ensembl. | 1 | |
Natural variantiVAR_043643 | 204 | T → R in allele MICA*004, allele MICA*014, allele MICA*032 and allele MICA*044. Corresponds to variant dbSNP:rs1131897Ensembl. | 1 | |
Natural variantiVAR_043644 | 229 | G → S in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1131898Ensembl. | 1 | |
Natural variantiVAR_043645 | 231 | Y → C in allele MICA*046. Corresponds to variant dbSNP:rs41546915Ensembl. | 1 | |
Natural variantiVAR_043646 | 233 | W → R in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051798Ensembl. | 1 | |
Natural variantiVAR_043647 | 236 | T → I in allele MICA*008, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1140700Ensembl. | 1 | |
Natural variantiVAR_043648 | 238 | S → T in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051799Ensembl. | 1 | |
Natural variantiVAR_043649 | 244 | V → L in allele MICA*016 and allele MICA*039. Corresponds to variant dbSNP:rs41540613EnsemblClinVar. | 1 | |
Natural variantiVAR_043869 | 253 | W → S in allele MICA*056. Corresponds to variant dbSNP:rs72558175Ensembl. | 1 | |
Natural variantiVAR_043650 | 274 | Q → R in allele MICA*005, allele MICA*008, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*045, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1063635Ensembl. | 1 | |
Natural variantiVAR_043651 | 279 | R → S in allele MICA*043. Corresponds to variant dbSNP:rs41557614Ensembl. | 1 | |
Natural variantiVAR_043652 | 291 | S → G in allele MICA*054. Corresponds to variant dbSNP:rs61759927Ensembl. | 1 | |
Natural variantiVAR_043653 | 294 | P → A in allele MICA*011, allele MICA*030 and allele MICA*047. Corresponds to variant dbSNP:rs41553616Ensembl. | 1 | |
Natural variantiVAR_043654 | 300 – 383 | VLVLQ…STEGA → CWCFRVIGRHSMFLLLLLLL LLLLLFLLLLFSTSVVVRRK HQLQRVQSS in allele MICA*015 and allele MICA*017. Add BLAST | 84 | |
Natural variantiVAR_043655 | 318 – 383 | AAIFV…STEGA → GCCYFCYYYFLCPLL in allele MICA*008, allele MICA*023, allele MICA*028 and allele MICA*053. Add BLAST | 66 | |
Natural variantiVAR_043656 | 319 | A → AA in allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*027, allele MICA*033, allele MICA*048, allele MICA*054 and allele MICA*056. | 1 | |
Natural variantiVAR_043657 | 319 | A → AAA in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*011, allele MICA*026, allele MICA*047 and allele MICA*049. | 1 | |
Natural variantiVAR_043658 | 319 | A → AAAA in allele MICA*050. | 1 | |
Natural variantiVAR_043659 | 319 | A → AAAAA in allele MICA*055. | 1 | |
Natural variantiVAR_043660 | 319 | A → AAAAAA in allele MICA*002, allele MICA*041, allele MICA*046 and allele MICA*052. | 1 | |
Natural variantiVAR_043661 | 319 | A → AAAAAAA in allele MICA*020. | 1 | |
Natural variantiVAR_043662 | 328 | V → I in allele MICA*052. Corresponds to variant dbSNP:rs72558178Ensembl. | 1 | |
Natural variantiVAR_043663 | 329 | R → C in allele MICA*002, allele MICA*011, allele MICA*020, allele MICA*041, allele MICA*043, allele MICA*046, allele MICA*047, allele MICA*050 and allele MICA*052. Corresponds to variant dbSNP:rs41554412Ensembl. | 1 | |
Natural variantiVAR_043664 | 356 | T → M in allele MICA*049. Corresponds to variant dbSNP:rs41546114Ensembl. | 1 | |
Natural variantiVAR_043665 | 373 | D → A in allele MICA*004, allele MICA*006, allele MICA*010, allele MICA*011, allele MICA*016, allele MICA*019, allele MICA*048 and allele MICA*049. Corresponds to variant dbSNP:rs9266825Ensembl. | 1 | |
Natural variantiVAR_043666 | 377 | T → A in allele MICA*011. Corresponds to variant dbSNP:rs41545814Ensembl. | 1 | |
Natural variantiVAR_043667 | 383 | A → T in allele MICA*018. Corresponds to variant dbSNP:rs1882Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055366 | 109 – 204 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14848 mRNA Translation: AAA21718.1 X92841 Genomic DNA Translation: CAA63427.1 AL845443 Genomic DNA Translation: CAI41907.1 CR847852 Genomic DNA Translation: CAQ11015.1 BC016929 mRNA Translation: AAH16929.1 BG114064 mRNA No translation available. L29406 Genomic DNA No translation available. L29408 Genomic DNA No translation available. L29409 Genomic DNA No translation available. L29411 Genomic DNA No translation available. U56940 Genomic DNA Translation: AAB41060.1 U56941 Genomic DNA Translation: AAB41061.1 U56942 Genomic DNA Translation: AAB41062.1 U56943 Genomic DNA Translation: AAB41063.1 U56944 Genomic DNA Translation: AAB41064.1 U56945 Genomic DNA Translation: AAB41065.1 U56946 Genomic DNA Translation: AAB41066.1 U56947 Genomic DNA Translation: AAB41067.1 U56948 Genomic DNA Translation: AAB41068.1 U56949 Genomic DNA Translation: AAB41069.1 U56950 Genomic DNA Translation: AAB41070.1 U56951 Genomic DNA Translation: AAB41071.1 U56952 Genomic DNA Translation: AAB41072.1 U56953 Genomic DNA Translation: AAB41073.1 U56954 Genomic DNA Translation: AAB41074.1 U56955 Genomic DNA Translation: AAB41075.1 Y16801 Genomic DNA Translation: CAA76393.1 Y16802 Genomic DNA Translation: CAA76394.1 Y16803 Genomic DNA Translation: CAA76395.1 Y16804 Genomic DNA Translation: CAA76396.1 Y16805 Genomic DNA Translation: CAA76397.1 Y16806 Genomic DNA Translation: CAA76398.1 Y16807 Genomic DNA Translation: CAA76399.1 Y16808 Genomic DNA Translation: CAA76400.1 Y16809 Genomic DNA Translation: CAA76401.1 Y16810 Genomic DNA Translation: CAA76402.1 Y16811 Genomic DNA Translation: CAA76403.1 Y18110 Genomic DNA Translation: CAA77029.1 Y18111 Genomic DNA Translation: CAA77030.1 Y18112 Genomic DNA Translation: CAA77031.1 AF097403 Genomic DNA Translation: AAD27006.1 AF097404 Genomic DNA Translation: AAD27007.1 AF097405 Genomic DNA Translation: AAD27008.1 AF097406 Genomic DNA Translation: AAD27009.1 AB015600 Genomic DNA Translation: BAA29034.1 AJ563426 Genomic DNA Translation: CAD91415.1 AH007168 Genomic DNA Translation: AAD01474.1 AH007170 Genomic DNA Translation: AAD01476.1 AH007171 Genomic DNA Translation: AAD01477.1 AH007173 Genomic DNA Translation: AAD01479.1 AH007174 Genomic DNA Translation: AAD01480.1 AH007186 Genomic DNA Translation: AAD01492.1 AH007175 Genomic DNA Translation: AAD01481.1 AH007176 Genomic DNA Translation: AAD01482.1 AH007177 Genomic DNA Translation: AAD01483.1 AH007178 Genomic DNA Translation: AAD01484.1 AH007179 Genomic DNA Translation: AAD01485.1 AH007180 Genomic DNA Translation: AAD01486.1 AH007182 Genomic DNA Translation: AAD01488.1 AH007183 Genomic DNA Translation: AAD01489.1 AH007184 Genomic DNA Translation: AAD01490.1 AH007185 Genomic DNA Translation: AAD01491.1 AH008136 Genomic DNA Translation: AAD52060.1 AH008137 Genomic DNA Translation: AAD52061.1 AH008138 Genomic DNA Translation: AAD52062.1 AH008139 Genomic DNA Translation: AAD52063.1 AH008140 Genomic DNA Translation: AAD52064.1 AH008141 Genomic DNA Translation: AAD52065.1 AH008142 Genomic DNA Translation: AAD52066.1 AH008143 Genomic DNA Translation: AAD52067.1 AH008144 Genomic DNA Translation: AAD52068.1 AH008145 Genomic DNA Translation: AAD52069.1 AH008146 Genomic DNA Translation: AAD52070.1 AH008147 Genomic DNA Translation: AAD52071.1 AH008148 Genomic DNA Translation: AAD52072.1 AH007169 Genomic DNA Translation: AAD01475.1 AH007172 Genomic DNA Translation: AAD01478.1 AH007167 Genomic DNA Translation: AAD01473.1 AH007181 Genomic DNA Translation: AAD01487.1 AH010819 Genomic DNA Translation: AAK58536.1 AH011143 Genomic DNA Translation: AAL13171.1 AH010820 Genomic DNA Translation: AAK58537.1 AH010821 Genomic DNA Translation: AAK58538.1 AH010545 Genomic DNA Translation: AAK19622.1 AH010526 Genomic DNA Translation: AAK17997.1 AH010568 Genomic DNA Translation: AAK25770.1 AH010569 Genomic DNA Translation: AAK25771.1 AH010532 Genomic DNA Translation: AAK18281.1 AH010546 Genomic DNA Translation: AAK19623.1 AH010560 Genomic DNA Translation: AAK20897.1 AH010561 Genomic DNA Translation: AAK20898.1 AH010587 Genomic DNA Translation: AAK27364.1 AH010562 Genomic DNA Translation: AAK20899.1 AH010571 Genomic DNA Translation: AAK26323.1 AH010572 Genomic DNA Translation: AAK26324.1 AH010740 Genomic DNA Translation: AAK51140.1 AJ250499 Genomic DNA Translation: CAC14280.1 AJ250500 Genomic DNA Translation: CAC14281.1 AJ250501 Genomic DNA Translation: CAC14282.1 AJ250502 Genomic DNA Translation: CAC14283.1 AJ250503 Genomic DNA Translation: CAC14284.1 AJ250504 Genomic DNA Translation: CAC14285.1 AJ250505 Genomic DNA Translation: CAC14286.1 AJ250506 Genomic DNA Translation: CAC14287.1 AJ250507 Genomic DNA Translation: CAC14288.1 AJ250802 Genomic DNA Translation: CAC15380.1 AJ250803 Genomic DNA Translation: CAC15381.1 AJ250804 Genomic DNA Translation: CAC15382.1 AJ250805 Genomic DNA Translation: CAC15383.1 AJ250990 Genomic DNA Translation: CAC16142.1 AJ250991 Genomic DNA Translation: CAC16143.1 AJ271789 Genomic DNA Translation: CAC27561.1 AY603357 Genomic DNA Translation: AAV39504.1 AJ249394 Genomic DNA Translation: CAB71317.1 AJ295250, AJ295251 Genomic DNA Translation: CAC88121.1 AJ580805 Genomic DNA Translation: CAE45581.1 AJ580806 Genomic DNA Translation: CAE45582.2 AH014149 Genomic DNA Translation: AAU95382.1 AM899996 Genomic DNA Translation: CAP12057.1 EU254723 Genomic DNA Translation: ABX54884.1 AM944063 Genomic DNA Translation: CAQ16171.1 AH006330 Genomic DNA Translation: AAC28941.1 AH006331 Genomic DNA Translation: AAC28942.1 AH006332 Genomic DNA Translation: AAC28943.1 AH006333 Genomic DNA Translation: AAC28944.1 AH006334 Genomic DNA Translation: AAC28945.1 AH007472 Genomic DNA Translation: AAD19598.1 AH007473 Genomic DNA Translation: AAD19599.1 AH007474 Genomic DNA Translation: AAD19600.1 AH007475 Genomic DNA Translation: AAD19601.1 AH007476 Genomic DNA Translation: AAD19602.1 AH007477 Genomic DNA Translation: AAD19603.1 AF106652, AF106650, AF106651 Genomic DNA Translation: AAD19604.1 AH007479 Genomic DNA Translation: AAD19605.1 EU267602 Genomic DNA Translation: ABX60404.1 AY095537 Genomic DNA Translation: AAM34484.1 |
PIRi | A55739 |
RefSeqi | NP_000238.1, NM_000247.2 [Q29983-1] |
Genome annotation databases
Ensembli | ENST00000400325; ENSP00000383179; ENSG00000183214 ENST00000418465; ENSP00000402134; ENSG00000235233 ENST00000547609; ENSP00000446963; ENSG00000183214 |
GeneIDi | 100507436 |
KEGGi | hsa:100507436 |
UCSCi | uc011ind.3, human [Q29983-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14848 mRNA Translation: AAA21718.1 X92841 Genomic DNA Translation: CAA63427.1 AL845443 Genomic DNA Translation: CAI41907.1 CR847852 Genomic DNA Translation: CAQ11015.1 BC016929 mRNA Translation: AAH16929.1 BG114064 mRNA No translation available. L29406 Genomic DNA No translation available. L29408 Genomic DNA No translation available. L29409 Genomic DNA No translation available. L29411 Genomic DNA No translation available. U56940 Genomic DNA Translation: AAB41060.1 U56941 Genomic DNA Translation: AAB41061.1 U56942 Genomic DNA Translation: AAB41062.1 U56943 Genomic DNA Translation: AAB41063.1 U56944 Genomic DNA Translation: AAB41064.1 U56945 Genomic DNA Translation: AAB41065.1 U56946 Genomic DNA Translation: AAB41066.1 U56947 Genomic DNA Translation: AAB41067.1 U56948 Genomic DNA Translation: AAB41068.1 U56949 Genomic DNA Translation: AAB41069.1 U56950 Genomic DNA Translation: AAB41070.1 U56951 Genomic DNA Translation: AAB41071.1 U56952 Genomic DNA Translation: AAB41072.1 U56953 Genomic DNA Translation: AAB41073.1 U56954 Genomic DNA Translation: AAB41074.1 U56955 Genomic DNA Translation: AAB41075.1 Y16801 Genomic DNA Translation: CAA76393.1 Y16802 Genomic DNA Translation: CAA76394.1 Y16803 Genomic DNA Translation: CAA76395.1 Y16804 Genomic DNA Translation: CAA76396.1 Y16805 Genomic DNA Translation: CAA76397.1 Y16806 Genomic DNA Translation: CAA76398.1 Y16807 Genomic DNA Translation: CAA76399.1 Y16808 Genomic DNA Translation: CAA76400.1 Y16809 Genomic DNA Translation: CAA76401.1 Y16810 Genomic DNA Translation: CAA76402.1 Y16811 Genomic DNA Translation: CAA76403.1 Y18110 Genomic DNA Translation: CAA77029.1 Y18111 Genomic DNA Translation: CAA77030.1 Y18112 Genomic DNA Translation: CAA77031.1 AF097403 Genomic DNA Translation: AAD27006.1 AF097404 Genomic DNA Translation: AAD27007.1 AF097405 Genomic DNA Translation: AAD27008.1 AF097406 Genomic DNA Translation: AAD27009.1 AB015600 Genomic DNA Translation: BAA29034.1 AJ563426 Genomic DNA Translation: CAD91415.1 AH007168 Genomic DNA Translation: AAD01474.1 AH007170 Genomic DNA Translation: AAD01476.1 AH007171 Genomic DNA Translation: AAD01477.1 AH007173 Genomic DNA Translation: AAD01479.1 AH007174 Genomic DNA Translation: AAD01480.1 AH007186 Genomic DNA Translation: AAD01492.1 AH007175 Genomic DNA Translation: AAD01481.1 AH007176 Genomic DNA Translation: AAD01482.1 AH007177 Genomic DNA Translation: AAD01483.1 AH007178 Genomic DNA Translation: AAD01484.1 AH007179 Genomic DNA Translation: AAD01485.1 AH007180 Genomic DNA Translation: AAD01486.1 AH007182 Genomic DNA Translation: AAD01488.1 AH007183 Genomic DNA Translation: AAD01489.1 AH007184 Genomic DNA Translation: AAD01490.1 AH007185 Genomic DNA Translation: AAD01491.1 AH008136 Genomic DNA Translation: AAD52060.1 AH008137 Genomic DNA Translation: AAD52061.1 AH008138 Genomic DNA Translation: AAD52062.1 AH008139 Genomic DNA Translation: AAD52063.1 AH008140 Genomic DNA Translation: AAD52064.1 AH008141 Genomic DNA Translation: AAD52065.1 AH008142 Genomic DNA Translation: AAD52066.1 AH008143 Genomic DNA Translation: AAD52067.1 AH008144 Genomic DNA Translation: AAD52068.1 AH008145 Genomic DNA Translation: AAD52069.1 AH008146 Genomic DNA Translation: AAD52070.1 AH008147 Genomic DNA Translation: AAD52071.1 AH008148 Genomic DNA Translation: AAD52072.1 AH007169 Genomic DNA Translation: AAD01475.1 AH007172 Genomic DNA Translation: AAD01478.1 AH007167 Genomic DNA Translation: AAD01473.1 AH007181 Genomic DNA Translation: AAD01487.1 AH010819 Genomic DNA Translation: AAK58536.1 AH011143 Genomic DNA Translation: AAL13171.1 AH010820 Genomic DNA Translation: AAK58537.1 AH010821 Genomic DNA Translation: AAK58538.1 AH010545 Genomic DNA Translation: AAK19622.1 AH010526 Genomic DNA Translation: AAK17997.1 AH010568 Genomic DNA Translation: AAK25770.1 AH010569 Genomic DNA Translation: AAK25771.1 AH010532 Genomic DNA Translation: AAK18281.1 AH010546 Genomic DNA Translation: AAK19623.1 AH010560 Genomic DNA Translation: AAK20897.1 AH010561 Genomic DNA Translation: AAK20898.1 AH010587 Genomic DNA Translation: AAK27364.1 AH010562 Genomic DNA Translation: AAK20899.1 AH010571 Genomic DNA Translation: AAK26323.1 AH010572 Genomic DNA Translation: AAK26324.1 AH010740 Genomic DNA Translation: AAK51140.1 AJ250499 Genomic DNA Translation: CAC14280.1 AJ250500 Genomic DNA Translation: CAC14281.1 AJ250501 Genomic DNA Translation: CAC14282.1 AJ250502 Genomic DNA Translation: CAC14283.1 AJ250503 Genomic DNA Translation: CAC14284.1 AJ250504 Genomic DNA Translation: CAC14285.1 AJ250505 Genomic DNA Translation: CAC14286.1 AJ250506 Genomic DNA Translation: CAC14287.1 AJ250507 Genomic DNA Translation: CAC14288.1 AJ250802 Genomic DNA Translation: CAC15380.1 AJ250803 Genomic DNA Translation: CAC15381.1 AJ250804 Genomic DNA Translation: CAC15382.1 AJ250805 Genomic DNA Translation: CAC15383.1 AJ250990 Genomic DNA Translation: CAC16142.1 AJ250991 Genomic DNA Translation: CAC16143.1 AJ271789 Genomic DNA Translation: CAC27561.1 AY603357 Genomic DNA Translation: AAV39504.1 AJ249394 Genomic DNA Translation: CAB71317.1 AJ295250, AJ295251 Genomic DNA Translation: CAC88121.1 AJ580805 Genomic DNA Translation: CAE45581.1 AJ580806 Genomic DNA Translation: CAE45582.2 AH014149 Genomic DNA Translation: AAU95382.1 AM899996 Genomic DNA Translation: CAP12057.1 EU254723 Genomic DNA Translation: ABX54884.1 AM944063 Genomic DNA Translation: CAQ16171.1 AH006330 Genomic DNA Translation: AAC28941.1 AH006331 Genomic DNA Translation: AAC28942.1 AH006332 Genomic DNA Translation: AAC28943.1 AH006333 Genomic DNA Translation: AAC28944.1 AH006334 Genomic DNA Translation: AAC28945.1 AH007472 Genomic DNA Translation: AAD19598.1 AH007473 Genomic DNA Translation: AAD19599.1 AH007474 Genomic DNA Translation: AAD19600.1 AH007475 Genomic DNA Translation: AAD19601.1 AH007476 Genomic DNA Translation: AAD19602.1 AH007477 Genomic DNA Translation: AAD19603.1 AF106652, AF106650, AF106651 Genomic DNA Translation: AAD19604.1 AH007479 Genomic DNA Translation: AAD19605.1 EU267602 Genomic DNA Translation: ABX60404.1 AY095537 Genomic DNA Translation: AAM34484.1 |
PIRi | A55739 |
RefSeqi | NP_000238.1, NM_000247.2 [Q29983-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B3J | X-ray | 3.00 | A | 24-297 | [»] | |
1HYR | X-ray | 2.70 | C | 24-297 | [»] | |
SMRi | Q29983 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 319735, 88 interactors |
CORUMi | Q29983 |
DIPi | DIP-29681N |
IntActi | Q29983, 33 interactors |
MINTi | Q29983 |
STRINGi | 9606.ENSP00000413079 |
PTM databases
GlyConnecti | 1510, 2 N-Linked glycans (2 sites) |
GlyGeni | Q29983, 6 sites, 2 N-linked glycans (2 sites) |
iPTMneti | Q29983 |
PhosphoSitePlusi | Q29983 |
SwissPalmi | Q29983 |
Genetic variation databases
BioMutai | MICA |
DMDMi | 74740024 |
Proteomic databases
EPDi | Q29983 |
jPOSTi | Q29983 |
MassIVEi | Q29983 |
MaxQBi | Q29983 |
PeptideAtlasi | Q29983 |
PRIDEi | Q29983 |
ProteomicsDBi | 61284 [Q29983-1] |
Protocols and materials databases
DNASUi | 100507436 |
Genome annotation databases
Ensembli | ENST00000400325; ENSP00000383179; ENSG00000183214 ENST00000418465; ENSP00000402134; ENSG00000235233 ENST00000547609; ENSP00000446963; ENSG00000183214 |
GeneIDi | 100507436 |
KEGGi | hsa:100507436 |
UCSCi | uc011ind.3, human [Q29983-1] |
Organism-specific databases
CTDi | 100507436 |
DisGeNETi | 100507436 |
GeneCardsi | MICA |
HGNCi | HGNC:7090, MICA |
MIMi | 177900, phenotype 600169, gene 607507, phenotype |
neXtProti | NX_Q29983 |
PharmGKBi | PA30811 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU00, Eukaryota |
InParanoidi | Q29983 |
OMAi | ICQGEEQ |
OrthoDBi | 1276422at2759 |
PhylomeDBi | Q29983 |
Enzyme and pathway databases
PathwayCommonsi | Q29983 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q29983 |
Miscellaneous databases
BioGRID-ORCSi | 100507436, 1 hit in 1003 CRISPR screens |
ChiTaRSi | MICA, human |
EvolutionaryTracei | Q29983 |
GeneWikii | MHC_class_I_polypeptide-related_sequence_A |
GenomeRNAii | 100507436 |
Pharosi | Q29983, Tbio |
PROi | PR:Q29983 |
RNActi | Q29983, protein |
SOURCEi | Search... |
Family and domain databases
DisProti | DP00670 |
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MICA_HUMAN | |
Accessioni | Q29983Primary (citable) accession number: Q29983 Secondary accession number(s): A8KQR0 Q9UE11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families