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UniProtKB - Q29983 (MICA_HUMAN)

Protein

MHC class I polypeptide-related sequence A

Gene

MICA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.5 Publications

Miscellaneous

Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.1 Publication

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processAdaptive immunity, Cytolysis, Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
MHC class I polypeptide-related sequence A
Short name:
MIC-A
Gene namesi
Name:MICAImported
Synonyms:PERB11.11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7090 MICA
MIMi600169 gene
neXtProtiNX_Q29983

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 307ExtracellularSequence analysisAdd BLAST284
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 383CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
Psoriasis 1 (PSORS1)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
See also OMIM:177900
Psoriatic arthritis (PSORAS)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
See also OMIM:607507

Organism-specific databases

DisGeNETi100507436
MIMi177900 phenotype
607507 phenotype
PharmGKBiPA30811

Polymorphism and mutation databases

DMDMi74740024

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000033714624 – 383MHC class I polypeptide-related sequence ASequence analysisAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 64PROSITE-ProRule annotation1 Publication
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 187PROSITE-ProRule annotation1 Publication
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 282PROSITE-ProRule annotation1 Publication
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.1 Publication
Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ29983
MaxQBiQ29983
PeptideAtlasiQ29983
PRIDEiQ29983
ProteomicsDBi61284

PTM databases

GlyConnecti1510
iPTMnetiQ29983
PhosphoSitePlusiQ29983
SwissPalmiQ29983

Miscellaneous databases

PMAP-CutDBiQ29983

Expressioni

Tissue specificityi

Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.7 Publications

Inductioni

By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.8 Publications

Organism-specific databases

HPAiHPA064618

Interactioni

Subunit structurei

Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.7 Publications
(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL142.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi319735, 42 interactors
CORUMiQ29983
DIPiDIP-29681N
IntActiQ29983, 3 interactors
MINTiQ29983

Structurei

Secondary structure

1383
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00670
ProteinModelPortaliQ29983
SMRiQ29983
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ29983

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 296Ig-like C1-typeSequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the MHC class I family. MIC subfamily.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106364
InParanoidiQ29983
KOiK07985
OrthoDBiEOG091G0ANY
PhylomeDBiQ29983

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q29983-1) [UniParc]FASTAAdd to basket
Also known as: MICA11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH 
        60         70         80         90        100
LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL 
       110        120        130        140        150
AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETKEW 
       160        170        180        190        200
TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLKSGVV 
       210        220        230        240        250
LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR QDGVSLSHDT 
       260        270        280        290        300
QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV 
       310        320        330        340        350
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD 
       360        370        380 
QHPVGTSDHR DATQLGFQPL MSDLGSTGST EGA
Length:383
Mass (Da):42,915
Last modified:November 1, 1996 - v1
Checksum:i1FE084813DDA13A8
GO
Isoform 21 Publication (identifier: Q29983-2) [UniParc]FASTAAdd to basket
Also known as: MICA21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     109-204: Missing.

Note: Found in about 10% of examined clones.
Show »
Length:287
Mass (Da):31,577
Checksum:i0D41D7919769F469
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PPN1A0A1W2PPN1_HUMAN
MHC class I polypeptide-related seq...
MICA
385Annotation score:
A0A140T986A0A140T986_HUMAN
MHC class I polypeptide-related seq...
MICA
342Annotation score:
Q96QC4Q96QC4_HUMAN
MHC class I polypeptide-related seq...
MICA hCG_2001511
332Annotation score:
A0A1W2PRA6A0A1W2PRA6_HUMAN
MHC class I polypeptide-related seq...
MICA
332Annotation score:
A0A0G2JJ55A0A0G2JJ55_HUMAN
MHC class I polypeptide-related seq...
MICA
194Annotation score:
A0A140T9M1A0A140T9M1_HUMAN
MHC class I polypeptide-related seq...
MICA
247Annotation score:
A0A140T8Z6A0A140T8Z6_HUMAN
MHC class I polypeptide-related seq...
MICA
245Annotation score:
A0A140T9B8A0A140T9B8_HUMAN
MHC class I polypeptide-related seq...
MICA
276Annotation score:
A0A140T9I5A0A140T9I5_HUMAN
MHC class I polypeptide-related seq...
MICA
274Annotation score:
A0A0G2JK11A0A0G2JK11_HUMAN
MHC class I polypeptide-related seq...
MICA
289Annotation score:
There are more potential isoformsShow all

Polymorphismi

The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04362529R → P in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding. 1 PublicationCorresponds to variant dbSNP:rs9380254Ensembl.1
Natural variantiVAR_04362637W → G in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055. Corresponds to variant dbSNP:rs1063630Ensembl.1
Natural variantiVAR_04362747T → A in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056. Corresponds to variant dbSNP:rs1051785Ensembl.1
Natural variantiVAR_04362849V → G in allele MICA*041. Corresponds to variant dbSNP:rs17200158Ensembl.1
Natural variantiVAR_04362959C → Y in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051786Ensembl.1
Natural variantiVAR_043630114Q → R in allele MICA*017. Corresponds to variant dbSNP:rs41558312Ensembl.1
Natural variantiVAR_043631128R → K in allele MICA*036. Corresponds to variant dbSNP:rs41557113Ensembl.1
Natural variantiVAR_043632137G → R in allele MICA*014 and allele MICA*015. Corresponds to variant dbSNP:rs41556715Ensembl.1
Natural variantiVAR_043633145L → V in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*044 and allele MICA*049. Corresponds to variant dbSNP:rs1051790Ensembl.1
Natural variantiVAR_043634147T → S in allele MICA*033. Corresponds to variant dbSNP:rs41539919Ensembl.1
Natural variantiVAR_043635148K → E in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*012, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*018, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056. Corresponds to variant dbSNP:rs1051791Ensembl.1
Natural variantiVAR_043636152M → V in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056; reduces binding affinity for KLRK1. Corresponds to variant dbSNP:rs1051792Ensembl.1
Natural variantiVAR_043637165V → I in allele MICA*029. Corresponds to variant dbSNP:rs3819269Ensembl.1
Natural variantiVAR_043638174M → V in allele MICA*011 and allele MICA*034. Corresponds to variant dbSNP:rs41560824Ensembl.1
Natural variantiVAR_043639179H → L in allele MICA*012, allele MICA*032 and allele MICA*043. Corresponds to variant dbSNP:rs3819268Ensembl.1
Natural variantiVAR_043640196K → E in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*014, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051794Ensembl.1
Natural variantiVAR_043641198G → S in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*031, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*049, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1131896Ensembl.1
Natural variantiVAR_043642199V → I in allele MICA*006. Corresponds to variant dbSNP:rs41549718Ensembl.1
Natural variantiVAR_043643204T → R in allele MICA*004, allele MICA*014, allele MICA*032 and allele MICA*044. Corresponds to variant dbSNP:rs1131897Ensembl.1
Natural variantiVAR_043644229G → S in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1131898Ensembl.1
Natural variantiVAR_043645231Y → C in allele MICA*046. Corresponds to variant dbSNP:rs41546915Ensembl.1
Natural variantiVAR_043646233W → R in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051798Ensembl.1
Natural variantiVAR_043647236T → I in allele MICA*008, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1140700Ensembl.1
Natural variantiVAR_043648238S → T in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1051799Ensembl.1
Natural variantiVAR_043649244V → L in allele MICA*016 and allele MICA*039. Corresponds to variant dbSNP:rs41540613EnsemblClinVar.1
Natural variantiVAR_043869253W → S in allele MICA*056. Corresponds to variant dbSNP:rs72558175Ensembl.1
Natural variantiVAR_043650274Q → R in allele MICA*005, allele MICA*008, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*045, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant dbSNP:rs1063635Ensembl.1
Natural variantiVAR_043651279R → S in allele MICA*043. Corresponds to variant dbSNP:rs41557614Ensembl.1
Natural variantiVAR_043652291S → G in allele MICA*054. Corresponds to variant dbSNP:rs61759927Ensembl.1
Natural variantiVAR_043653294P → A in allele MICA*011, allele MICA*030 and allele MICA*047. Corresponds to variant dbSNP:rs41553616Ensembl.1
Natural variantiVAR_043654300 – 383VLVLQ…STEGA → CWCFRVIGRHSMFLLLLLLL LLLLLFLLLLFSTSVVVRRK HQLQRVQSS in allele MICA*015 and allele MICA*017. Add BLAST84
Natural variantiVAR_043655318 – 383AAIFV…STEGA → GCCYFCYYYFLCPLL in allele MICA*008, allele MICA*023, allele MICA*028 and allele MICA*053. Add BLAST66
Natural variantiVAR_043656319A → AA in allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*027, allele MICA*033, allele MICA*048, allele MICA*054 and allele MICA*056. 1
Natural variantiVAR_043657319A → AAA in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*011, allele MICA*026, allele MICA*047 and allele MICA*049. 1
Natural variantiVAR_043658319A → AAAA in allele MICA*050. 1
Natural variantiVAR_043659319A → AAAAA in allele MICA*055. 1
Natural variantiVAR_043660319A → AAAAAA in allele MICA*002, allele MICA*041, allele MICA*046 and allele MICA*052. 1
Natural variantiVAR_043661319A → AAAAAAA in allele MICA*020. 1
Natural variantiVAR_043662328V → I in allele MICA*052. Corresponds to variant dbSNP:rs72558178Ensembl.1
Natural variantiVAR_043663329R → C in allele MICA*002, allele MICA*011, allele MICA*020, allele MICA*041, allele MICA*043, allele MICA*046, allele MICA*047, allele MICA*050 and allele MICA*052. Corresponds to variant dbSNP:rs41554412Ensembl.1
Natural variantiVAR_043664356T → M in allele MICA*049. Corresponds to variant dbSNP:rs41546114Ensembl.1
Natural variantiVAR_043665373D → A in allele MICA*004, allele MICA*006, allele MICA*010, allele MICA*011, allele MICA*016, allele MICA*019, allele MICA*048 and allele MICA*049. Corresponds to variant dbSNP:rs9266825Ensembl.1
Natural variantiVAR_043666377T → A in allele MICA*011. Corresponds to variant dbSNP:rs41545814Ensembl.1
Natural variantiVAR_043667383A → T in allele MICA*018. Corresponds to variant dbSNP:rs1882Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055366109 – 204Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14848 mRNA Translation: AAA21718.1
X92841 Genomic DNA Translation: CAA63427.1
AL845443 Genomic DNA Translation: CAI41907.1
CR847852 Genomic DNA Translation: CAQ11015.1
BC016929 mRNA Translation: AAH16929.1
BG114064 mRNA No translation available.
L29406 Genomic DNA No translation available.
L29408 Genomic DNA No translation available.
L29409 Genomic DNA No translation available.
L29411 Genomic DNA No translation available.
U56940 Genomic DNA Translation: AAB41060.1
U56941 Genomic DNA Translation: AAB41061.1
U56942 Genomic DNA Translation: AAB41062.1
U56943 Genomic DNA Translation: AAB41063.1
U56944 Genomic DNA Translation: AAB41064.1
U56945 Genomic DNA Translation: AAB41065.1
U56946 Genomic DNA Translation: AAB41066.1
U56947 Genomic DNA Translation: AAB41067.1
U56948 Genomic DNA Translation: AAB41068.1
U56949 Genomic DNA Translation: AAB41069.1
U56950 Genomic DNA Translation: AAB41070.1
U56951 Genomic DNA Translation: AAB41071.1
U56952 Genomic DNA Translation: AAB41072.1
U56953 Genomic DNA Translation: AAB41073.1
U56954 Genomic DNA Translation: AAB41074.1
U56955 Genomic DNA Translation: AAB41075.1
Y16801 Genomic DNA Translation: CAA76393.1
Y16802 Genomic DNA Translation: CAA76394.1
Y16803 Genomic DNA Translation: CAA76395.1
Y16804 Genomic DNA Translation: CAA76396.1
Y16805 Genomic DNA Translation: CAA76397.1
Y16806 Genomic DNA Translation: CAA76398.1
Y16807 Genomic DNA Translation: CAA76399.1
Y16808 Genomic DNA Translation: CAA76400.1
Y16809 Genomic DNA Translation: CAA76401.1
Y16810 Genomic DNA Translation: CAA76402.1
Y16811 Genomic DNA Translation: CAA76403.1
Y18110 Genomic DNA Translation: CAA77029.1
Y18111 Genomic DNA Translation: CAA77030.1
Y18112 Genomic DNA Translation: CAA77031.1
AF097403 Genomic DNA Translation: AAD27006.1
AF097404 Genomic DNA Translation: AAD27007.1
AF097405 Genomic DNA Translation: AAD27008.1
AF097406 Genomic DNA Translation: AAD27009.1
AB015600 Genomic DNA Translation: BAA29034.1
AJ563426 Genomic DNA Translation: CAD91415.1
AH007168 Genomic DNA Translation: AAD01474.1
AH007170 Genomic DNA Translation: AAD01476.1
AH007171 Genomic DNA Translation: AAD01477.1
AH007173 Genomic DNA Translation: AAD01479.1
AH007174 Genomic DNA Translation: AAD01480.1
AH007186 Genomic DNA Translation: AAD01492.1
AH007175 Genomic DNA Translation: AAD01481.1
AH007176 Genomic DNA Translation: AAD01482.1
AH007177 Genomic DNA Translation: AAD01483.1
AH007178 Genomic DNA Translation: AAD01484.1
AH007179 Genomic DNA Translation: AAD01485.1
AH007180 Genomic DNA Translation: AAD01486.1
AH007182 Genomic DNA Translation: AAD01488.1
AH007183 Genomic DNA Translation: AAD01489.1
AH007184 Genomic DNA Translation: AAD01490.1
AH007185 Genomic DNA Translation: AAD01491.1
AH008136 Genomic DNA Translation: AAD52060.1
AH008137 Genomic DNA Translation: AAD52061.1
AH008138 Genomic DNA Translation: AAD52062.1
AH008139 Genomic DNA Translation: AAD52063.1
AH008140 Genomic DNA Translation: AAD52064.1
AH008141 Genomic DNA Translation: AAD52065.1
AH008142 Genomic DNA Translation: AAD52066.1
AH008143 Genomic DNA Translation: AAD52067.1
AH008144 Genomic DNA Translation: AAD52068.1
AH008145 Genomic DNA Translation: AAD52069.1
AH008146 Genomic DNA Translation: AAD52070.1
AH008147 Genomic DNA Translation: AAD52071.1
AH008148 Genomic DNA Translation: AAD52072.1
AH007169 Genomic DNA Translation: AAD01475.1
AH007172 Genomic DNA Translation: AAD01478.1
AH007167 Genomic DNA Translation: AAD01473.1
AH007181 Genomic DNA Translation: AAD01487.1
AH010819 Genomic DNA Translation: AAK58536.1
AH011143 Genomic DNA Translation: AAL13171.1
AH010820 Genomic DNA Translation: AAK58537.1
AH010821 Genomic DNA Translation: AAK58538.1
AH010545 Genomic DNA Translation: AAK19622.1
AH010526 Genomic DNA Translation: AAK17997.1
AH010568 Genomic DNA Translation: AAK25770.1
AH010569 Genomic DNA Translation: AAK25771.1
AH010532 Genomic DNA Translation: AAK18281.1
AH010546 Genomic DNA Translation: AAK19623.1
AH010560 Genomic DNA Translation: AAK20897.1
AH010561 Genomic DNA Translation: AAK20898.1
AH010587 Genomic DNA Translation: AAK27364.1
AH010562 Genomic DNA Translation: AAK20899.1
AH010571 Genomic DNA Translation: AAK26323.1
AH010572 Genomic DNA Translation: AAK26324.1
AH010740 Genomic DNA Translation: AAK51140.1
AJ250499 Genomic DNA Translation: CAC14280.1
AJ250500 Genomic DNA Translation: CAC14281.1
AJ250501 Genomic DNA Translation: CAC14282.1
AJ250502 Genomic DNA Translation: CAC14283.1
AJ250503 Genomic DNA Translation: CAC14284.1
AJ250504 Genomic DNA Translation: CAC14285.1
AJ250505 Genomic DNA Translation: CAC14286.1
AJ250506 Genomic DNA Translation: CAC14287.1
AJ250507 Genomic DNA Translation: CAC14288.1
AJ250802 Genomic DNA Translation: CAC15380.1
AJ250803 Genomic DNA Translation: CAC15381.1
AJ250804 Genomic DNA Translation: CAC15382.1
AJ250805 Genomic DNA Translation: CAC15383.1
AJ250990 Genomic DNA Translation: CAC16142.1
AJ250991 Genomic DNA Translation: CAC16143.1
AJ271789 Genomic DNA Translation: CAC27561.1
AY603357 Genomic DNA Translation: AAV39504.1
AJ249394 Genomic DNA Translation: CAB71317.1
AJ295250, AJ295251 Genomic DNA Translation: CAC88121.1
AJ580805 Genomic DNA Translation: CAE45581.1
AJ580806 Genomic DNA Translation: CAE45582.2
AH014149 Genomic DNA Translation: AAU95382.1
AM899996 Genomic DNA Translation: CAP12057.1
EU254723 Genomic DNA Translation: ABX54884.1
AM944063 Genomic DNA Translation: CAQ16171.1
AH006330 Genomic DNA Translation: AAC28941.1
AH006331 Genomic DNA Translation: AAC28942.1
AH006332 Genomic DNA Translation: AAC28943.1
AH006333 Genomic DNA Translation: AAC28944.1
AH006334 Genomic DNA Translation: AAC28945.1
AH007472 Genomic DNA Translation: AAD19598.1
AH007473 Genomic DNA Translation: AAD19599.1
AH007474 Genomic DNA Translation: AAD19600.1
AH007475 Genomic DNA Translation: AAD19601.1
AH007476 Genomic DNA Translation: AAD19602.1
AH007477 Genomic DNA Translation: AAD19603.1
AF106652, AF106650, AF106651 Genomic DNA Translation: AAD19604.1
AH007479 Genomic DNA Translation: AAD19605.1
EU267602 Genomic DNA Translation: ABX60404.1
AY095537 Genomic DNA Translation: AAM34484.1
PIRiA55739
RefSeqiNP_000238.1, NM_000247.2 [Q29983-1]
UniGeneiHs.130838

Genome annotation databases

EnsembliENST00000400325; ENSP00000383179; ENSG00000183214 [Q29983-1]
ENST00000418465; ENSP00000402134; ENSG00000235233
ENST00000547609; ENSP00000446963; ENSG00000183214 [Q29983-1]
GeneIDi100507436
KEGGihsa:100507436
UCSCiuc011ind.3 human [Q29983-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14848 mRNA Translation: AAA21718.1
X92841 Genomic DNA Translation: CAA63427.1
AL845443 Genomic DNA Translation: CAI41907.1
CR847852 Genomic DNA Translation: CAQ11015.1
BC016929 mRNA Translation: AAH16929.1
BG114064 mRNA No translation available.
L29406 Genomic DNA No translation available.
L29408 Genomic DNA No translation available.
L29409 Genomic DNA No translation available.
L29411 Genomic DNA No translation available.
U56940 Genomic DNA Translation: AAB41060.1
U56941 Genomic DNA Translation: AAB41061.1
U56942 Genomic DNA Translation: AAB41062.1
U56943 Genomic DNA Translation: AAB41063.1
U56944 Genomic DNA Translation: AAB41064.1
U56945 Genomic DNA Translation: AAB41065.1
U56946 Genomic DNA Translation: AAB41066.1
U56947 Genomic DNA Translation: AAB41067.1
U56948 Genomic DNA Translation: AAB41068.1
U56949 Genomic DNA Translation: AAB41069.1
U56950 Genomic DNA Translation: AAB41070.1
U56951 Genomic DNA Translation: AAB41071.1
U56952 Genomic DNA Translation: AAB41072.1
U56953 Genomic DNA Translation: AAB41073.1
U56954 Genomic DNA Translation: AAB41074.1
U56955 Genomic DNA Translation: AAB41075.1
Y16801 Genomic DNA Translation: CAA76393.1
Y16802 Genomic DNA Translation: CAA76394.1
Y16803 Genomic DNA Translation: CAA76395.1
Y16804 Genomic DNA Translation: CAA76396.1
Y16805 Genomic DNA Translation: CAA76397.1
Y16806 Genomic DNA Translation: CAA76398.1
Y16807 Genomic DNA Translation: CAA76399.1
Y16808 Genomic DNA Translation: CAA76400.1
Y16809 Genomic DNA Translation: CAA76401.1
Y16810 Genomic DNA Translation: CAA76402.1
Y16811 Genomic DNA Translation: CAA76403.1
Y18110 Genomic DNA Translation: CAA77029.1
Y18111 Genomic DNA Translation: CAA77030.1
Y18112 Genomic DNA Translation: CAA77031.1
AF097403 Genomic DNA Translation: AAD27006.1
AF097404 Genomic DNA Translation: AAD27007.1
AF097405 Genomic DNA Translation: AAD27008.1
AF097406 Genomic DNA Translation: AAD27009.1
AB015600 Genomic DNA Translation: BAA29034.1
AJ563426 Genomic DNA Translation: CAD91415.1
AH007168 Genomic DNA Translation: AAD01474.1
AH007170 Genomic DNA Translation: AAD01476.1
AH007171 Genomic DNA Translation: AAD01477.1
AH007173 Genomic DNA Translation: AAD01479.1
AH007174 Genomic DNA Translation: AAD01480.1
AH007186 Genomic DNA Translation: AAD01492.1
AH007175 Genomic DNA Translation: AAD01481.1
AH007176 Genomic DNA Translation: AAD01482.1
AH007177 Genomic DNA Translation: AAD01483.1
AH007178 Genomic DNA Translation: AAD01484.1
AH007179 Genomic DNA Translation: AAD01485.1
AH007180 Genomic DNA Translation: AAD01486.1
AH007182 Genomic DNA Translation: AAD01488.1
AH007183 Genomic DNA Translation: AAD01489.1
AH007184 Genomic DNA Translation: AAD01490.1
AH007185 Genomic DNA Translation: AAD01491.1
AH008136 Genomic DNA Translation: AAD52060.1
AH008137 Genomic DNA Translation: AAD52061.1
AH008138 Genomic DNA Translation: AAD52062.1
AH008139 Genomic DNA Translation: AAD52063.1
AH008140 Genomic DNA Translation: AAD52064.1
AH008141 Genomic DNA Translation: AAD52065.1
AH008142 Genomic DNA Translation: AAD52066.1
AH008143 Genomic DNA Translation: AAD52067.1
AH008144 Genomic DNA Translation: AAD52068.1
AH008145 Genomic DNA Translation: AAD52069.1
AH008146 Genomic DNA Translation: AAD52070.1
AH008147 Genomic DNA Translation: AAD52071.1
AH008148 Genomic DNA Translation: AAD52072.1
AH007169 Genomic DNA Translation: AAD01475.1
AH007172 Genomic DNA Translation: AAD01478.1
AH007167 Genomic DNA Translation: AAD01473.1
AH007181 Genomic DNA Translation: AAD01487.1
AH010819 Genomic DNA Translation: AAK58536.1
AH011143 Genomic DNA Translation: AAL13171.1
AH010820 Genomic DNA Translation: AAK58537.1
AH010821 Genomic DNA Translation: AAK58538.1
AH010545 Genomic DNA Translation: AAK19622.1
AH010526 Genomic DNA Translation: AAK17997.1
AH010568 Genomic DNA Translation: AAK25770.1
AH010569 Genomic DNA Translation: AAK25771.1
AH010532 Genomic DNA Translation: AAK18281.1
AH010546 Genomic DNA Translation: AAK19623.1
AH010560 Genomic DNA Translation: AAK20897.1
AH010561 Genomic DNA Translation: AAK20898.1
AH010587 Genomic DNA Translation: AAK27364.1
AH010562 Genomic DNA Translation: AAK20899.1
AH010571 Genomic DNA Translation: AAK26323.1
AH010572 Genomic DNA Translation: AAK26324.1
AH010740 Genomic DNA Translation: AAK51140.1
AJ250499 Genomic DNA Translation: CAC14280.1
AJ250500 Genomic DNA Translation: CAC14281.1
AJ250501 Genomic DNA Translation: CAC14282.1
AJ250502 Genomic DNA Translation: CAC14283.1
AJ250503 Genomic DNA Translation: CAC14284.1
AJ250504 Genomic DNA Translation: CAC14285.1
AJ250505 Genomic DNA Translation: CAC14286.1
AJ250506 Genomic DNA Translation: CAC14287.1
AJ250507 Genomic DNA Translation: CAC14288.1
AJ250802 Genomic DNA Translation: CAC15380.1
AJ250803 Genomic DNA Translation: CAC15381.1
AJ250804 Genomic DNA Translation: CAC15382.1
AJ250805 Genomic DNA Translation: CAC15383.1
AJ250990 Genomic DNA Translation: CAC16142.1
AJ250991 Genomic DNA Translation: CAC16143.1
AJ271789 Genomic DNA Translation: CAC27561.1
AY603357 Genomic DNA Translation: AAV39504.1
AJ249394 Genomic DNA Translation: CAB71317.1
AJ295250, AJ295251 Genomic DNA Translation: CAC88121.1
AJ580805 Genomic DNA Translation: CAE45581.1
AJ580806 Genomic DNA Translation: CAE45582.2
AH014149 Genomic DNA Translation: AAU95382.1
AM899996 Genomic DNA Translation: CAP12057.1
EU254723 Genomic DNA Translation: ABX54884.1
AM944063 Genomic DNA Translation: CAQ16171.1
AH006330 Genomic DNA Translation: AAC28941.1
AH006331 Genomic DNA Translation: AAC28942.1
AH006332 Genomic DNA Translation: AAC28943.1
AH006333 Genomic DNA Translation: AAC28944.1
AH006334 Genomic DNA Translation: AAC28945.1
AH007472 Genomic DNA Translation: AAD19598.1
AH007473 Genomic DNA Translation: AAD19599.1
AH007474 Genomic DNA Translation: AAD19600.1
AH007475 Genomic DNA Translation: AAD19601.1
AH007476 Genomic DNA Translation: AAD19602.1
AH007477 Genomic DNA Translation: AAD19603.1
AF106652, AF106650, AF106651 Genomic DNA Translation: AAD19604.1
AH007479 Genomic DNA Translation: AAD19605.1
EU267602 Genomic DNA Translation: ABX60404.1
AY095537 Genomic DNA Translation: AAM34484.1
PIRiA55739
RefSeqiNP_000238.1, NM_000247.2 [Q29983-1]
UniGeneiHs.130838

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B3JX-ray3.00A24-297[»]
1HYRX-ray2.70C24-297[»]
DisProtiDP00670
ProteinModelPortaliQ29983
SMRiQ29983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi319735, 42 interactors
CORUMiQ29983
DIPiDIP-29681N
IntActiQ29983, 3 interactors
MINTiQ29983

PTM databases

GlyConnecti1510
iPTMnetiQ29983
PhosphoSitePlusiQ29983
SwissPalmiQ29983

Polymorphism and mutation databases

DMDMi74740024

Proteomic databases

EPDiQ29983
MaxQBiQ29983
PeptideAtlasiQ29983
PRIDEiQ29983
ProteomicsDBi61284

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400325; ENSP00000383179; ENSG00000183214 [Q29983-1]
ENST00000418465; ENSP00000402134; ENSG00000235233
ENST00000547609; ENSP00000446963; ENSG00000183214 [Q29983-1]
GeneIDi100507436
KEGGihsa:100507436
UCSCiuc011ind.3 human [Q29983-1]

Organism-specific databases

CTDi100507436
DisGeNETi100507436
GeneCardsiMICA
HGNCiHGNC:7090 MICA
HPAiHPA064618
MIMi177900 phenotype
600169 gene
607507 phenotype
neXtProtiNX_Q29983
PharmGKBiPA30811
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG106364
InParanoidiQ29983
KOiK07985
OrthoDBiEOG091G0ANY
PhylomeDBiQ29983

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiMICA human
EvolutionaryTraceiQ29983
GeneWikiiMHC_class_I_polypeptide-related_sequence_A
GenomeRNAii100507436
PMAP-CutDBiQ29983
PROiPR:Q29983
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMICA_HUMAN
AccessioniPrimary (citable) accession number: Q29983
Secondary accession number(s): A8KQR0
, A9LRW5, A9QVE0, B1VJF1, O60917, O60918, O60919, O60920, O60933, O77956, O78150, O78151, O78152, O78153, O97987, O97988, O97989, O97990, O97991, O97992, O97993, O97994, O97995, O98234, O98235, O98236, O98237, O98238, P79506, P79507, P79508, P79509, P79510, P79511, P79512, P79513, P79514, P79515, P79516, P79517, P79518, P79519, P79520, P79521, Q5C9P8, Q5XM81, Q70I48, Q70I49, Q7JFH9, Q7JFI0, Q7JFI1, Q7JFI2, Q7YQ98, Q861I1, Q95464, Q95HA2, Q95HD6, Q95HN4, Q95HN5, Q95HN6, Q95IB2, Q95IY7, Q99692, Q9BCR3, Q9BCR4, Q9BCR5, Q9BCR6, Q9BCR7, Q9BCR8, Q9BCR9, Q9BCS0, Q9BCS1, Q9BCS2, Q9BCS3, Q9BCS4, Q9BD20, Q9GIZ1, Q9GIZ2, Q9GIZ3, Q9GIZ4, Q9GIZ5, Q9GIZ6, Q9GJ01, Q9GJ02, Q9GJ03, Q9GJ04, Q9GJ05, Q9GJ06, Q9GJ07, Q9GJ08, Q9GJ09, Q9MY21, Q9TQ86, Q9TQ87, Q9TQ88, Q9TQ89, Q9TQ92, Q9TQ93, Q9TQ94, Q9TQ95, Q9TQ96, Q9TQ97, Q9TQ98, Q9TQ99, Q9TQA0, Q9TQA1, Q9TQA2, Q9TQA3, Q9TQA4, Q9TQI9, Q9TQJ0, Q9TQJ1, Q9TQJ9, Q9TQK0, Q9TQK1, Q9TQK2, Q9TQK8, Q9TQK9, Q9TQL0, Q9TQL1, Q9TQL2, Q9TQL3, Q9TQL4, Q9UE04, Q9UE05, Q9UE06, Q9UE11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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