UniProtKB - Q29467 (I5P1_CANLF)
Protein
Inositol polyphosphate-5-phosphatase A
Gene
INPP5A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8198557). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).By similarity1 Publication
Catalytic activityi
- 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate1 PublicationEC:3.1.3.561 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate1 PublicationEC:3.1.3.561 PublicationThis reaction proceeds in the forward1 Publication direction.
Activity regulationi
Inhibited by EDTA and 2,3-bisphosphoglycerate.1 Publication
Kineticsi
- KM=28.3 µM for inositol 1,4,5- trisphosphate1 Publication
- KM=3.4 µM for inositol 1,3,4,5-tetrasphosphate1 Publication
GO - Molecular functioni
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-polyphosphate 5-phosphatase activity Source: UniProtKB
GO - Biological processi
- inositol phosphate dephosphorylation Source: GO_Central
- inositol phosphate-mediated signaling Source: GO_Central
- negative regulation of neuron death Source: UniProtKB
- phosphatidylinositol dephosphorylation Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.1.3.56, 1153 |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol polyphosphate-5-phosphatase A (EC:3.1.3.561 Publication)Alternative name(s): Type I inositol 1,4,5-trisphosphate 5-phosphatase Short name: 5PTase |
Gene namesi | Name:INPP5A |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity
Other locations
- dendrite By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- dendrite Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209718 | 1 – 409 | Inositol polyphosphate-5-phosphatase AAdd BLAST | 409 | |
PropeptideiPRO_0000396779 | 410 – 412 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 409 | S-farnesyl cysteineBy similarity | 1 |
Post-translational modificationi
Isoprenylation at Cys-409 is required for localization at the membrane.By similarity
Keywords - PTMi
Lipoprotein, PrenylationProteomic databases
PaxDbi | Q29467 |
Interactioni
Subunit structurei
Interacts with TASOR.
By similarityProtein-protein interaction databases
STRINGi | 9612.ENSCAFP00000016395 |
Family & Domainsi
Sequence similaritiesi
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.Curated
Phylogenomic databases
eggNOGi | KOG1976, Eukaryota |
InParanoidi | Q29467 |
OMAi | CTGDHKP |
OrthoDBi | 642737at2759 |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR039737, INPP5A IPR000300, IPPc |
PANTHERi | PTHR12997, PTHR12997, 1 hit |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q29467-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA
60 70 80 90 100
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENFKSQEH
110 120 130 140 150
FTALGSFYFL HESLKNIYQF DFKAKKYKKV TGKEIYSDTL ESTPMLEKEK
160 170 180 190 200
FPQDYFPECK WSRKGFVRTR WCVADCAFDL VNIHLFHDAS NLVAWETSPS
210 220 230 240 250
VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA
260 270 280 290 300
TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFHYFN QEVFRDNNGT
310 320 330 340 350
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDSGQGRQYM NTRCPAWCDR
360 370 380 390 400
VLMSPSAREL ILKSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIAPGAGK
410
PHAHVHKCCV VQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75094 mRNA Translation: CAA52985.1 |
PIRi | S44357 |
RefSeqi | NP_001003257.1, NM_001003257.1 |
Genome annotation databases
GeneIDi | 403937 |
KEGGi | cfa:403937 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75094 mRNA Translation: CAA52985.1 |
PIRi | S44357 |
RefSeqi | NP_001003257.1, NM_001003257.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000016395 |
Proteomic databases
PaxDbi | Q29467 |
Genome annotation databases
GeneIDi | 403937 |
KEGGi | cfa:403937 |
Organism-specific databases
CTDi | 3632 |
Phylogenomic databases
eggNOGi | KOG1976, Eukaryota |
InParanoidi | Q29467 |
OMAi | CTGDHKP |
OrthoDBi | 642737at2759 |
Enzyme and pathway databases
BRENDAi | 3.1.3.56, 1153 |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR039737, INPP5A IPR000300, IPPc |
PANTHERi | PTHR12997, PTHR12997, 1 hit |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I5P1_CANLF | |
Accessioni | Q29467Primary (citable) accession number: Q29467 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families