UniProtKB - Q29400 (IBP2_SHEEP)
Protein
Insulin-like growth factor-binding protein 2
Gene
IGFBP2
Organism
Ovis aries (Sheep)
Status
Functioni
Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity
GO - Molecular functioni
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
GO - Biological processi
- positive regulation of activated T cell proliferation Source: UniProtKB
- regulation of growth Source: UniProtKB-KW
- regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
- response to insulin Source: AgBase
Keywordsi
Molecular function | Growth factor binding |
Biological process | Growth regulation |
Protein family/group databases
MEROPSi | I31.953 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 2Short name: IBP-2 Short name: IGF-binding protein 2 Short name: IGFBP-2 |
Gene namesi | Name:IGFBP2 |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: AgBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | By similarityAdd BLAST | 33 | |
ChainiPRO_0000014374 | 34 – 317 | Insulin-like growth factor-binding protein 2Add BLAST | 284 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 219 ↔ 253 | PROSITE-ProRule annotation | ||
Disulfide bondi | 264 ↔ 275 | PROSITE-ProRule annotation | ||
Disulfide bondi | 277 ↔ 298 | PROSITE-ProRule annotation |
Post-translational modificationi
O-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinExpressioni
Tissue specificityi
Expressed in abundance in selected adult tissues, namely liver, kidney, adrenal, pituitary and choroid plexus.1 Publication
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
By similarityGO - Molecular functioni
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000020858 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 126 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 216 – 298 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 83 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 293 – 295 | Cell attachment siteSequence analysis | 3 |
Domaini
The C-terminus is required for IGF-binding and growth inhibition.By similarity
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q29400-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPRLGGPAL LLLPPLLLLL LLGAGGGDCG ARAEVLFRCP PCTPESLAAC
60 70 80 90 100
KPPPGAAAGP AGDARVPCEL VREPGCGCCS VCARLEGERC GVYTPRCGQG
110 120 130 140 150
LRCYPNPGSE LPLRALVHGE GTCEKHGDAE YSASPEQVAD NGEEHSEGGQ
160 170 180 190 200
VENHVDGNVN LMGGGGGAGR KPLKFRMKEL AVFREKVTEQ HRQMGKGGKH
210 220 230 240 250
HLGLEEPKKL RPPPARTPCQ QELDQVLERI STMRLPDERG PLEHLYSLHI
260 270 280 290 300
PNCDKHGLYN LKQCKMSLNG QRGECWCVNP NTGKLIQGAP TIRGDPECHL
310
FYNEQQGARG VHTQRMQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S44612 mRNA Translation: AAB23135.1 |
PIRi | I46916 |
RefSeqi | NP_001009436.1, NM_001009436.1 |
Genome annotation databases
GeneIDi | 443469 |
KEGGi | oas:443469 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S44612 mRNA Translation: AAB23135.1 |
PIRi | I46916 |
RefSeqi | NP_001009436.1, NM_001009436.1 |
3D structure databases
BMRBi | Q29400 |
SMRi | Q29400 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000020858 |
Protein family/group databases
MEROPSi | I31.953 |
Genome annotation databases
GeneIDi | 443469 |
KEGGi | oas:443469 |
Organism-specific databases
CTDi | 3485 |
Phylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP2_SHEEP | |
Accessioni | Q29400Primary (citable) accession number: Q29400 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |