UniProtKB - Q29318 (DHSO_PIG)
Sorbitol dehydrogenase
SORD
Functioni
Polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2-oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity).
Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity).
By similarityCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 44 | Zinc; catalyticBy similarity | 1 | |
Binding sitei | 50 | SubstrateBy similarity | 1 | |
Metal bindingi | 69 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 70 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- D-xylulose reductase activity Source: UniProtKB-EC
- L-iditol 2-dehydrogenase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- flagellated sperm motility Source: UniProtKB
- sorbitol catabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SORD |
Organismi | Sus scrofa (Pig)Imported |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion membrane By similarity; Peripheral membrane protein By similarity
Other locations
- flagellum By similarity
Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.By similarity
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Other locations
- motile cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Flagellum, Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160818 | 1 – ›97 | Sorbitol dehydrogenaseAdd BLAST | ›97 |
Proteomic databases
PaxDbi | Q29318 |
PeptideAtlasi | Q29318 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 9823.ENSSSCP00000005040 |
Structurei
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
InParanoidi | Q29318 |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Fragment.
10 20 30 40 50
MAAAKPENLS LVVHGPGDLR LENYPIPEPG PNXVLLKMHS VGICGSDVHY
60 70 80 90
WQHGRIGNFV VKKPMVLGHE ASGTXVKVGS LVTHLKPGDR XAXEPGA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 97 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | F14714 mRNA Translation: CAA23205.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | F14714 mRNA Translation: CAA23205.1 |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000005040 |
Proteomic databases
PaxDbi | Q29318 |
PeptideAtlasi | Q29318 |
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
InParanoidi | Q29318 |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHSO_PIG | |
Accessioni | Q29318Primary (citable) accession number: Q29318 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 102 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families