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Entry version 134 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Tenascin

Gene

TNC

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tenascin
Short name:
TN
Alternative name(s):
Cytotactin
GMEM
GP 150-225
Glioma-associated-extracellular matrix antigen
Hexabrachion
JI
Myotendinous antigen
Neuronectin
P230
Tenascin-C
Short name:
TN-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNC
Synonyms:HXB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000774223 – 1746TenascinAdd BLAST1724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi64InterchainPROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei65PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi190 ↔ 200By similarity
Disulfide bondi194 ↔ 205By similarity
Disulfide bondi207 ↔ 216By similarity
Disulfide bondi221 ↔ 231By similarity
Disulfide bondi225 ↔ 236By similarity
Disulfide bondi238 ↔ 247By similarity
Disulfide bondi252 ↔ 263By similarity
Disulfide bondi256 ↔ 268By similarity
Disulfide bondi270 ↔ 279By similarity
Disulfide bondi284 ↔ 294By similarity
Disulfide bondi288 ↔ 299By similarity
Disulfide bondi301 ↔ 310By similarity
Disulfide bondi315 ↔ 325By similarity
Disulfide bondi319 ↔ 330By similarity
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 341By similarity
Disulfide bondi346 ↔ 356By similarity
Disulfide bondi350 ↔ 361By similarity
Disulfide bondi363 ↔ 372By similarity
Disulfide bondi377 ↔ 387By similarity
Disulfide bondi381 ↔ 392By similarity
Disulfide bondi394 ↔ 403By similarity
Disulfide bondi408 ↔ 418By similarity
Disulfide bondi412 ↔ 423By similarity
Disulfide bondi425 ↔ 434By similarity
Disulfide bondi439 ↔ 449By similarity
Disulfide bondi443 ↔ 454By similarity
Disulfide bondi456 ↔ 465By similarity
Disulfide bondi470 ↔ 480By similarity
Disulfide bondi474 ↔ 485By similarity
Disulfide bondi487 ↔ 496By similarity
Disulfide bondi501 ↔ 511By similarity
Disulfide bondi505 ↔ 516By similarity
Disulfide bondi518 ↔ 527By similarity
Disulfide bondi532 ↔ 542By similarity
Disulfide bondi536 ↔ 547By similarity
Disulfide bondi549 ↔ 558By similarity
Disulfide bondi563 ↔ 573By similarity
Disulfide bondi567 ↔ 578By similarity
Disulfide bondi580 ↔ 589By similarity
Disulfide bondi594 ↔ 604By similarity
Disulfide bondi598 ↔ 609By similarity
Disulfide bondi611 ↔ 620By similarity
Glycosylationi788N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei905PhosphothreonineBy similarity1
Glycosylationi1034N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1079N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1354N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q29116

PeptideAtlas

More...
PeptideAtlasi
Q29116

PRoteomics IDEntifications database

More...
PRIDEi
Q29116

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Submaxillary glands and brain.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly expressed in the embryonic and early postnatal stages. Little or no detection in adult brain.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TGF-beta.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000005891

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q29116

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 186EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST13
Domaini187 – 217EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini218 – 249EGF-like 3PROSITE-ProRule annotationAdd BLAST32
Domaini250 – 280EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini281 – 311EGF-like 5PROSITE-ProRule annotationAdd BLAST31
Domaini312 – 342EGF-like 6PROSITE-ProRule annotationAdd BLAST31
Domaini343 – 373EGF-like 7PROSITE-ProRule annotationAdd BLAST31
Domaini374 – 404EGF-like 8PROSITE-ProRule annotationAdd BLAST31
Domaini405 – 435EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini436 – 466EGF-like 10PROSITE-ProRule annotationAdd BLAST31
Domaini467 – 497EGF-like 11PROSITE-ProRule annotationAdd BLAST31
Domaini498 – 528EGF-like 12PROSITE-ProRule annotationAdd BLAST31
Domaini529 – 559EGF-like 13PROSITE-ProRule annotationAdd BLAST31
Domaini560 – 589EGF-like 14PROSITE-ProRule annotationAdd BLAST30
Domaini590 – 620EGF-like 15PROSITE-ProRule annotationAdd BLAST31
Domaini625 – 717Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini718 – 801Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST84
Domaini805 – 894Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini895 – 988Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini989 – 1075Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST87
Domaini1076 – 1166Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini1167 – 1256Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini1257 – 1346Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST90
Domaini1347 – 1433Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST87
Domaini1434 – 1522Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST89
Domaini1520 – 1735Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 185Involved in hexamer formationAdd BLAST163

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili118 – 145Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.Curated

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2579 Eukaryota
ENOG410ZYS4 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234355

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q29116

KEGG Orthology (KO)

More...
KOi
K06252

Database of Orthologous Groups

More...
OrthoDBi
18592at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 10 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC

The PANTHER Classification System

More...
PANTHERi
PTHR46708:SF1 PTHR46708:SF1, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 3 hits
PF18720 EGF_Tenascin, 10 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 7 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 14 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms are produced in a tissue- and time-specific manner during development.
Isoform Minor-2 (identifier: Q29116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVVTRLLVG TFLASLALPA QGGVLKKVIR HKRQTGVNVT LPEESQPVVF
60 70 80 90 100
NHVYNIKLPV GSQCSVDLES ASGDKDLAAP SEPSESVQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TSGAGCCLQP
160 170 180 190 200
AEGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PSNCHLRGQC
210 220 230 240 250
VDGQCVCNEG FTGEDCSQLA CPSDCNDQGK CVNGVCVCFE GYSGVDCSRE
260 270 280 290 300
TCPVPCSEEH GRCVDGRCVC QEGFAGEDCN EPLCLHNCHG RGRCVENECV
310 320 330 340 350
CDEGFTGEDC GELICPKDCF DRGRCINGTC YCDEGFEGED CGRLACPHGC
360 370 380 390 400
RGRGRCEEGQ CVCDEGFAGA DCSERRCPSD CHNRGRCLDG RCECDDGFEG
410 420 430 440 450
EDCGELRCPG GCSGHGRCVN GQCVCDEGRT GEDCSQLRCP NDCHGRGRCV
460 470 480 490 500
QGRCECEHGF QGYDCSEMSC PHDCHQHGRC VNGMCVCDDG YTGEDCRELR
510 520 530 540 550
CPGDCSQRGR CVDGRCVCEH GFAGPDCADL ACPSDCHGRG RCVNGQCVCH
560 570 580 590 600
EGFTGKDCGQ RRCPGDCHGQ GRCVDGQCVC HEGFTGLDCG QRSCPNDCSN
610 620 630 640 650
WGQCVSGRCI CNEGYSGEDC SQVSPPKDLI VTEVTEETVN LAWDNEMRVT
660 670 680 690 700
EYLIVYTPTH EDGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKK
710 720 730 740 750
SIPVSARVAT YLPTPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
760 770 780 790 800
KEDEGEITKS LRRPETTYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT
810 820 830 840 850
TRLDAPSQIE AKDVTDTTAL ITWFKPLAEI DGIELTYGIK DVPGDRTTID
860 870 880 890 900
LTHEENQYSI GNLKPDTEYE VSLISRRADM SSNPAKETFT TGLDAPRNLR
910 920 930 940 950
RISQTDNSIT LEWRNGKAAA DTYRIKYAPI SGGDHAEVEV PRSPQTTTKA
960 970 980 990 1000
TLTGLRPGTE YGIGVSAVKG DKESDPATIN AATDLDPPKD FRVSELKESS
1010 1020 1030 1040 1050
LTLLWRTPLA KFDRYRLNYG LPSGQPVEVQ LPRNATSYIL RGLEPGQEYT
1060 1070 1080 1090 1100
ILLTAEKGRH KSKPARVKAS TAGEPEIGNL SVSDITPESF SLSWTATEGA
1110 1120 1130 1140 1150
FETFTIEIID SNRFLETMEY NISGAERTAH ISGLRPGNDF IVYLSGLAPG
1160 1170 1180 1190 1200
IQTKPISATA TTEAEPEVDN LLVSDATPDG FRLSWTADEG VFDSFVLKIR
1210 1220 1230 1240 1250
DTKKQSEPLE ITLLASERTR DITGLREATE YEIELYGISS GKRSQPVSAI
1260 1270 1280 1290 1300
ATTAMGSPKE ITFSDITENS ATVSWMVPTA QVESFRITYV PITGGAPSVV
1310 1320 1330 1340 1350
TVDGTKTQTR LLRLLPGVEY LVSVIAVKGF EESEPVSGTL TTALDGPSGL
1360 1370 1380 1390 1400
VTANITDSEA LAMWQPAIAP VDHYVISYTG DRVPEITRTV SGNTVEYALT
1410 1420 1430 1440 1450
NLEPATEYTL RIFAEKGPQK SSTITTKFTT DLDSPRDLTA TEVQSETALL
1460 1470 1480 1490 1500
TWRPPRASVT GYLLVYESVD GTLKEVVVGP ETTSYSLSGL SPSTHYTARI
1510 1520 1530 1540 1550
QALNGPLRSK MSQTVFTTIG LLYPFPRDCS QAMLNGDTTS GLYTIYVNND
1560 1570 1580 1590 1600
KAQKLEVFCD MTSDSGGWIV FLRRKNGRED FYRNWKAYAA GFGDLKEEFW
1610 1620 1630 1640 1650
LGLDALSKIT AQGQYELRVD LRDHGETAYA VYDRFSVGDA RTRYKLKVEG
1660 1670 1680 1690 1700
YSGTAGDSMA YHNGRSFSTF DKDTDSAITN CALSYKGAFW YKNCHRVNLM
1710 1720 1730 1740
GRYGDNSHSQ GVNWFHWKGH EYSIQFAEMK LRPSNFRNLE GRRKRA
Length:1,746
Mass (Da):191,400
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56549B1CFE5E5C88
GO
Isoform Major (identifier: Q29116-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1162: Missing.

Show »
Length:1,655
Mass (Da):181,692
Checksum:i5120853B14467398
GO
Isoform Minor-1 (identifier: Q29116-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1253: Missing.

Show »
Length:1,564
Mass (Da):171,634
Checksum:i7333CCF143243FFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1007T → M AA sequence (PubMed:9498558).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0014171072 – 1253Missing in isoform Minor-1. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_0014161072 – 1162Missing in isoform Major. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X61599 mRNA Translation: CAA43796.1

Protein sequence database of the Protein Information Resource

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PIRi
S19694

NCBI Reference Sequences

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RefSeqi
NP_999395.1, NM_214230.1 [Q29116-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
397460

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ssc:397460

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61599 mRNA Translation: CAA43796.1
PIRiS19694
RefSeqiNP_999395.1, NM_214230.1 [Q29116-1]

3D structure databases

SMRiQ29116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005891

Proteomic databases

PaxDbiQ29116
PeptideAtlasiQ29116
PRIDEiQ29116

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397460
KEGGissc:397460

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3371

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
HOGENOMiHOG000234355
InParanoidiQ29116
KOiK06252
OrthoDBi18592at2759

Family and domain databases

CDDicd00063 FN3, 10 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR46708:SF1 PTHR46708:SF1, 3 hits
PfamiView protein in Pfam
PF07974 EGF_2, 3 hits
PF18720 EGF_Tenascin, 10 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 10 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 10 hits
SUPFAMiSSF49265 SSF49265, 7 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 14 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENA_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q29116
Secondary accession number(s): P98142
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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