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Entry version 127 (23 Feb 2022)
Sequence version 1 (01 Nov 1997)
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Protein

Prostaglandin reductase 1

Gene

PTGR1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:8576264, PubMed:9461497, PubMed:10837478, PubMed:11688989).

Preferentially uses NADPH over NADH as cofactor (PubMed:9461497).

Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:9461497, PubMed:11688989).

Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:8576264, PubMed:8394361).

Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4 and may promote neutrophil recruitment at the inflammatory site (PubMed:10837478, PubMed:11688989).

Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity).

May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).

By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Down-regulated by nonsteroidal anti-inflammatory drugs diclofenac, indomethacin and niflumic acid.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.7 µM for 15-oxo-PGE11 Publication
  2. KM=19 µM for 15-oxo-PGE21 Publication
  3. KM=10 µM for LTB41 Publication
  4. KM=153 µM for NADH1 Publication
  5. KM=15 µM for NADPH1 Publication
  6. KM=8 µM for LTB41 Publication
  7. KM=14 µM for 6-trans-LTB41 Publication
  8. KM=1.5 µM for NADP+1 Publication
  1. Vmax=2470 nmol/min/mg enzyme with 15-keto-PGE1 as substrate1 Publication
  2. Vmax=847 nmol/min/mg enzyme with 15-keto-PGE2 as substrate1 Publication
  3. Vmax=7.0 nmol/min/mg enzyme with LTB4 as substrate1 Publication
  4. Vmax=2352 nmol/min/mg enzyme with NADH as substrate1 Publication
  5. Vmax=729 nmol/min/mg enzyme with NADPH as substrate1 Publication
  6. Vmax=8.0 nmol/min/mg enzyme with LTB4 as substrate1 Publication

pH dependencei

Optimum pH is 7.5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei178NADPBy similarity1
Binding sitei193NADPBy similarity1
Binding sitei217NADPBy similarity1
Binding sitei321NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi152 – 155NADPBy similarity4
Nucleotide bindingi239 – 245NADPBy similarity7
Nucleotide bindingi270 – 272NADPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism, Prostaglandin metabolism
LigandNAD, NADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.48, 6170

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000733

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin reductase 1
Short name:
PRG-1
Alternative name(s):
15-oxoprostaglandin 13-reductase1 Publication (EC:1.3.1.481 Publication)
Dithiolethione-inducible gene 1 proteinBy similarity
Short name:
D3T-inducible gene 1 proteinBy similarity
Short name:
DIG-1By similarity
Leukotriene B4 12-hydroxydehydrogenase1 Publication
NAD(P)H-dependent alkenal/one oxidoreductase (EC:1.3.1.74By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGR1
Synonyms:LTB4DH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1
  • UP000008227 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi149A → E: Reduces activity by 90%. 1 Publication1
Mutagenesisi149A → V: Reduces activity by half. 1 Publication1
Mutagenesisi150A → V: No effect. 1 Publication1
Mutagenesisi152G → V: Loss of activity. 1 Publication1
Mutagenesisi155G → V: Reduces activity by 99%. 1 Publication1
Mutagenesisi159G → V: Reduces activity by 60%. 1 Publication1
Mutagenesisi166G → V: Reduces activity by 99%. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002180671 – 329Prostaglandin reductase 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphothreonineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei178N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei178N6-acetyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Hydroxylation, Phosphoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q29073

PRoteomics IDEntifications database

More...
PRIDEi
Q29073

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously distributed in various tissues and leukocytes, the kidney and liver had the highest enzyme activities.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer or homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000023451

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q29073

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1196, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q29073

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08294, leukotriene_B4_DH_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013149, ADH_C
IPR041694, ADH_N_2
IPR011032, GroES-like_sf
IPR045010, MDR_fam
IPR036291, NAD(P)-bd_dom_sf
IPR020843, PKS_ER
IPR014190, PTGR1

The PANTHER Classification System

More...
PANTHERi
PTHR43205, PTHR43205, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16884, ADH_N_2, 1 hit
PF00107, ADH_zinc_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00829, PKS_ER, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50129, SSF50129, 2 hits
SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02825, B4_12hDH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q29073-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRAKSWTLK KHFVGYPTPS NFELKTVELP PLKNGEVLLE ALFLTVDPYM
60 70 80 90 100
RIAARKLKEG DMMMGEQVAR VIESKNAAFP TGTIVVALLG WTTHSISDGK
110 120 130 140 150
NLERLLAEWP DTLPLSLTLG TVGMPGLTAY FGLLDICGLK GGETVMVNAA
160 170 180 190 200
AGAVGSVVGQ IAKLKGCKVV GAAGSDEKVA CLKKYGFDVA FNYKTIESLE
210 220 230 240 250
ETLKKASPEG YDCYFDNVGG EFSNAVTSQM KKFGRIAICG AISTYNRTGP
260 270 280 290 300
PPPGPPPEVV IYNELCFQGF IVTRWQGEVR QKALRDLLKW VSEGKIQYHE
310 320
HITEGFENMP AAFMGMLKGE NLGKAIVKA
Length:329
Mass (Da):35,762
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8893061A7EFBEEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118T → A in AAC39170 (PubMed:9461497).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D49386 mRNA Translation: BAA08381.1
U87622 mRNA Translation: AAC39170.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A47421

NCBI Reference Sequences

More...
RefSeqi
NP_999550.1, NM_214385.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00005017036; ENSSSCP00005010141; ENSSSCG00005011097
ENSSSCT00005017053; ENSSSCP00005010153; ENSSSCG00005011097
ENSSSCT00005017071; ENSSSCP00005010169; ENSSSCG00005011097
ENSSSCT00005017093; ENSSSCP00005010183; ENSSSCG00005011097
ENSSSCT00005017113; ENSSSCP00005010196; ENSSSCG00005011097
ENSSSCT00035022658; ENSSSCP00035008340; ENSSSCG00035017612
ENSSSCT00070044298; ENSSSCP00070037326; ENSSSCG00070022262
ENSSSCT00070044304; ENSSSCP00070037331; ENSSSCG00070022262
ENSSSCT00070044312; ENSSSCP00070037338; ENSSSCG00070022262
ENSSSCT00070044338; ENSSSCP00070037361; ENSSSCG00070022262
ENSSSCT00070044343; ENSSSCP00070037366; ENSSSCG00070022262

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397678

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49386 mRNA Translation: BAA08381.1
U87622 mRNA Translation: AAC39170.1
PIRiA47421
RefSeqiNP_999550.1, NM_214385.1

3D structure databases

SMRiQ29073
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023451

Chemistry databases

SwissLipidsiSLP:000000733

Proteomic databases

PeptideAtlasiQ29073
PRIDEiQ29073

Genome annotation databases

EnsembliENSSSCT00005017036; ENSSSCP00005010141; ENSSSCG00005011097
ENSSSCT00005017053; ENSSSCP00005010153; ENSSSCG00005011097
ENSSSCT00005017071; ENSSSCP00005010169; ENSSSCG00005011097
ENSSSCT00005017093; ENSSSCP00005010183; ENSSSCG00005011097
ENSSSCT00005017113; ENSSSCP00005010196; ENSSSCG00005011097
ENSSSCT00035022658; ENSSSCP00035008340; ENSSSCG00035017612
ENSSSCT00070044298; ENSSSCP00070037326; ENSSSCG00070022262
ENSSSCT00070044304; ENSSSCP00070037331; ENSSSCG00070022262
ENSSSCT00070044312; ENSSSCP00070037338; ENSSSCG00070022262
ENSSSCT00070044338; ENSSSCP00070037361; ENSSSCG00070022262
ENSSSCT00070044343; ENSSSCP00070037366; ENSSSCG00070022262
GeneIDi397678
KEGGissc:397678

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22949

Phylogenomic databases

eggNOGiKOG1196, Eukaryota
InParanoidiQ29073

Enzyme and pathway databases

BRENDAi1.3.1.48, 6170

Family and domain databases

CDDicd08294, leukotriene_B4_DH_like, 1 hit
InterProiView protein in InterPro
IPR013149, ADH_C
IPR041694, ADH_N_2
IPR011032, GroES-like_sf
IPR045010, MDR_fam
IPR036291, NAD(P)-bd_dom_sf
IPR020843, PKS_ER
IPR014190, PTGR1
PANTHERiPTHR43205, PTHR43205, 1 hit
PfamiView protein in Pfam
PF16884, ADH_N_2, 1 hit
PF00107, ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829, PKS_ER, 1 hit
SUPFAMiSSF50129, SSF50129, 2 hits
SSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR02825, B4_12hDH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGR1_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q29073
Secondary accession number(s): O62642
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 23, 2022
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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